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[1]孔宇虹 李元文 任琳 孙占学 赵雅静.自拟祛疣颗粒治疗多发性跖疣的疗效及对免疫功能的影响[J].环球中医药,2016,9(04):406-409.[doi:10.3969/j.issn.1674-1749.2016.04.006]
　KONG Yu-hong,LI Yuan-wen,REN Lin,et al.Effect of the self-made Quyou granules in the treatment of multiple verruca plantaris and its influence on immune function[J].,2016,9(04):406-409.[doi:10.3969/j.issn.1674-1749.2016.04.006]
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自拟祛疣颗粒治疗多发性跖疣的疗效及对 免疫功能的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年04期
页码:
406-409
栏目:
论著
出版日期:
2016-04-06

文章信息/Info

Title:
Effect of the self-made Quyou granules in the treatment of multiple verruca plantaris and its influence on immune function
作者:
孔宇虹 李元文 任琳 孙占学 赵雅静
100029 北京中医药大学[孔宇虹(博士研究生)、任琳(硕士研究生)]; 北京中医药大学东方医院皮肤性病科(孔宇虹、李元文、孙占学、赵雅静)
Author(s):
KONG Yu-hong;  LI Yuan-wen;  REN Lin;  et al.
Beijing University of Chinese Medicine,Beijing 100029,China
关键词:
跖疣;  寻常疣;  中药;  免疫功能;  冷冻
Keywords:
Plantar wart;  Verruca vulgaris;  Traditional Chinese medicine(TCM);  The immune function;  Cryotherapy
分类号:
R249
DOI:
10.3969/j.issn.1674-1749.2016.04.006
文献标志码:
A
摘要:
目的 观察自拟祛疣颗粒治疗多发性跖疣的临床疗效及其对机体免疫功能的影响。 方法 采用随机数字表分组法将60例多发性跖疣患者分为治疗组和对照组各30例,治疗组采用中药祛疣颗粒每天2剂(共4袋),其中1剂开水冲服,每次1袋,每天2次; 另1剂加枯矾10 g,加入热水冲化后浸泡患足,每次40分钟,每天1次,2周为一个疗程,2个疗程后观察并判定疗效。对照组采用液氮冷冻治疗,每2周1次,治疗4周后观察并判定疗效。结果 治疗组总有效率为89.7%,明显高于对照组(55.2%),经检验,两组总有效率比较具有统计学意义(P<0.05); 对T细胞亚群的影响比较,治疗组对外周血细胞免疫有一定的改善作用,CD4+增高,CD8+降低,CD4+/CD8+增高,而对照组对外周血T细胞亚群分布几乎无影响; 两组复发率的比较,治疗组复发率7.7%,明显优于对照组(50%)。结论 祛疣颗粒内服加外用治疗多发性跖疣具有安全有效,复发率低的特点,疗效明显优于冷冻治疗。
Abstract:
Objective To observe the effect of Quyou granules in the treatment of multiple verruca plantaris and its effects on the immune function. Methods 60 patients with multiple verruca plantaris were divided into treatment group and control group according to random numbers table, 30 cases in each. Treatment group was treated with traditional Chinese medicine(TCM)Quyou granules 2 doses(4 bags), of which 1 bag adding to boiling water, 1 bag each time, 2 times a day; the other 1 plus alum 10 g, adding hot water and soaking the affected foot, 40 minutes each time, 1 times a day, 2 weeks for a course of treatment, the curative effect was observed after 2 courses of treatment. The control group was treated with liquid nitrogen, 1 times per 2 week, 4 weeks after treatment, the curative effect was observed. Results Total effective rate was 89.7% in treatment group, which was significantly higher than that in the control group(55.2%), the result had statistical significance(P<0.05). Comparison of T cell subgroup, the treatment group had a certain effect on improving the peripheral immune cells,CD4+ was increased, CD8+ was reduced, CD4+/CD8+ was increased, while the control group almost had no effect. The recurrence rate was 7.7% in treatment group which was obviously better than that was 50% in control group. Conclusion The Quyou granules in the treatment of multiple verruca plantaris is safe and effective, and the recurrence rate is low, and curative effect is significantly better than cryotherapy.

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备注/Memo

备注/Memo:
基金项目: 国家中医药管理局“十二五”重点专科建设项目
作者简介: 孔宇虹(1980- ),女,2013级在读博士研究生,副主任医师。研究方向:中西医结合治疗皮肤病。E-mail:kongyuhong0709@163.com
通讯作者: 李元文(1962- ),本科,主任医师,教授,博士生导师。研究方向:中西医结合治疗皮肤病性病。E-mail:yuan-wen@sohu.com
更新日期/Last Update: 2016-04-06