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[1]郭岩松,柳海艳,钟赣生,等.甘遂半夏汤加减甘遂及不同品种甘草对腹水模型大鼠心肝肾功能的影响[J].环球中医药,2016,9(05):527-533.[doi:10.3969/j.issn.1674-1749.2016.05.003]
　GUO Yan-song,LIU Hai-yan,ZHONG Gan-sheng,et al.Comparing the effect of Gansui Banxia decoction plus or reduce kansui and varieties of glycyrrhiza on heart, liver and kidney function of ascites model rat[J].,2016,9(05):527-533.[doi:10.3969/j.issn.1674-1749.2016.05.003]
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甘遂半夏汤加减甘遂及不同品种甘草对腹水模型大鼠心肝肾功能的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年05期
页码:
527-533
栏目:
甘遂甘草反药研究专题
出版日期:
2016-05-06

文章信息/Info

Title:
Comparing the effect of Gansui Banxia decoction plus or reduce kansui and varieties of glycyrrhiza on heart, liver and kidney function of ascites model rat
作者:
郭岩松; 柳海艳; 钟赣生; 许皖; 张建美; 刘珍清; 修琳琳; 王思睿
100029 北京中医药大学基础医学院[郭岩松(硕士研究生)、许皖(硕士研究生)、张建美(硕士研究生)、修琳琳(博士研究生)、王思睿(硕士研究生)],基础医学院方药系(钟赣生、柳海艳),科研实验中心(刘珍清)
Author(s):
GUO Yan-song; LIU Hai-yan; ZHONG Gan-sheng; et al.
School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
十八反;  甘遂甘草反药组合;  甘草;  光果甘草;  胀果甘草
Keywords:
Eighteen incompatible medicaments;  Combination of incompatible herb of kansui and glycyrrhiza;  Glycyrrhiza uralensis Fisch.;  Glycyrrhiza glabra L.;  Glycyrrhiza inflata Bat.
分类号:
R285.5
DOI:
10.3969/j.issn.1674-1749.2016.05.003
文献标志码:
A
摘要:
目的 通过分析含不同品种甘草的甘遂半夏汤加减反药组合对腹水模型大鼠的心肝肾脏功能指标的变化,探讨甘草品种对甘遂甘草配伍“反”或“不反”的影响。方法 Wistar大鼠220只随机分成11组,空白组、模型组、阳性药组、全方炙甘草组、全方胀果组、全方光果组、去遂炙甘草组、去遂胀果组、去遂光果组、去草组、去草遂组,除空白组和模型组外连续给药10天,然后腹主动脉取血,离心,检测心肝肾功能相关指标。分析方法选择方差分析,方差齐采用LSD方法,方差不齐采用Dunnet T3分析方法。结果(1)在肝功能中TP和ALB合成方面,全方(炙胀果甘草)组的药效相对优于全方(炙光果甘草)组和全方(炙甘草)组,且三个全方组去掉一味反药或两味反药组在促进由于Walker-256细胞造成的大鼠肝脏ALB和TP合成降低方面的疗效优于三个全方组。(2)含甘遂与不同品种甘草反药组合的甘遂半夏汤全方在对Walker-256细胞造成的大鼠心功能、肾功能和肝功能中AST的含量、ALT的含量、AST/ALT比值和ALP含量变化方面无明显影响。结论 甘草、光果甘草和胀果甘草这三个不同品种的甘草对甘遂甘草反药组合在心功能、肾功能和肝功能中AST的含量、ALT的含量、AST/ALT比值和ALP含量方面无明显影响,但在改善由于Walker-256细胞造成的大鼠肝脏蛋白合成异常方面,胀果甘草优于光果甘草和甘草。
Abstract:
Objective To analyze the changes of varieties glycyrrhiza in modified Gansui Banxia decoction on heart liver and kidney function of malignant ascites rat model, and to explore the effects of glycyrrhiza varieties on the incompatible herb. Methods 220 Wistar rats were randomly divided into blank group, model group, positive group, the complete formula with Glycyrrhiza uralensis Fisch. group, the complete formula with Glycyrrhiza inflata Bat.group, the complete formula with Glycyrrhiza glabra L. group, the Glycyrrhiza uralensis Fisch. without kansui group, the Glycyrrhiza inflata Bat.without kansui group, the Glycyrrhiza glabra L. without kansui group, Gansui Banxia decoction without glycyrrhiza group, Gansui Banxia decoction without glycyrrhiza and kansui group, except the blank group and model group, other groups were intragastric administration for 10 days, the blood simple was collected to detect relevant indicators. The single factor ANOVA and Dunnet T3 analytical method was used for statistics. Results The effect of TP and ALB synthesis in the complete formula with Glycyrrhiza inflata Bat. group was better than that in the complete formula with Glycyrrhiza glabra L. group and Glycyrrhiza uralensis group, and the whole prescription was better than modified prescription. There had no obvious effect on AST, ALT, AST/ALT and ALP in the Gansui Banxia decoction with varieties glycyrrhiza. Conclusion There had no obvious effect on AST, ALT, AST/ALT and ALP in the Gansui Banxia decoction with varieties glycyrrhiza, but the improvement action of Glycyrrhiza inflata Bat. in protein synthesis was better than Glycyrrhiza glabra L. and Licorice.

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备注/Memo

备注/Memo:
基金项目: 国家重点基础研究发展计划(973计划)(2011CB505306); 北京中医药大学2016年度基本科研业务费项目(中青年教师类)(2016-JYB-JSMS-005)
作者简介: 郭岩松(1987- ),2013级在读硕士研究生。研究方向:中药药性理论研究。E-mail:gys_381878118@sina.com
通讯作者: 钟赣生(1961- ),硕士,教授,博士生导师。研究方向:中药药性理论研究。E-mail:zhonggansheng@sohu.com
更新日期/Last Update: 2016-05-06