|本期目录/Table of Contents|

[1]郝静,闫慧敏.养阴清瘀法治疗儿童过敏性紫癜性肾炎的临床观察[J].环球中医药,2016,9(05):544-548.[doi:10.3969/j.issn.1674-1749.2016.05.006]
　HAO Jing,YAN Hui-min..Clinical observation on the therapy of nourishing yin and blood stasis in treatment of Henoch Schonlein purpura nephritis in children[J].,2016,9(05):544-548.[doi:10.3969/j.issn.1674-1749.2016.05.006]
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养阴清瘀法治疗儿童过敏性紫癜性肾炎的临床观察()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年05期
页码:
544-548
栏目:
论著
出版日期:
2016-05-06

文章信息/Info

Title:
Clinical observation on the therapy of nourishing yin and blood stasis in treatment of Henoch Schonlein purpura nephritis in children
作者:
郝静; 闫慧敏
100045 首都医科大学附属北京儿童医院中医科
Author(s):
HAO Jing;  YAN Hui-min.
Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
关键词:
过敏性紫癜性肾炎;  养阴清瘀;  气阴两虚;  儿童
Keywords:
Henoch Schonlein purpura nephritis;  Therapy of nourishing yin and blood stasis;  Deficiency of both qi and yin;  Children
分类号:
R242
DOI:
10.3969/j.issn.1674-1749.2016.05.006
文献标志码:
A
摘要:
目的 应用中药养阴清瘀法治疗小儿过敏性紫癜性肾炎,进行临床观察并初步探讨其作用机制。方法 选择66例气阴两虚型过敏性紫癜性肾炎患儿,随机分为养阴清瘀法中药治疗组和西药治疗(福辛普利和双嘧达莫)组,对照观察两组治疗前及治疗后4周、8周中医证候、临床疗效和凝血、免疫等理化指标的改变情况。结果 较之西药对照组,中药治疗可以更有效改善中医证候,减轻血尿,降低IgA,提高CD4+水平,升高补体C3,降低D-二聚体值; 而对于轻度蛋白尿的治疗,两组疗效差别不大。结论 养阴清瘀法治疗小儿气阴两虚型过敏性紫癜性肾炎,可以有效缓解中医证候,降低血尿、蛋白尿,调节免疫,改善凝血机制。
Abstract:
Objective To observe the clinical effect of treating children's Henoch Schonlein purpura nephritis(HSPN)with the method of nourishing yin and blood stasis, and preliminary discuss the treating mechanism. Methods 66 cases of HSPN children with the type of deficiency of both qi and Yin, were randomly assigned for nourishing yin and clearing stasis method of Chinese medicine treatment group and western medicine treatment(fosinopril and dipyridamole)group. Before, after 4 weeks and 8 weeks of treatment, traditional Chinese medicine syndromes, clinical efficacy and blood coagulation, immune and other physical and chemical indicators were observed in both groups. Results Compared with the western medicine, traditional Chinese medicine treatment could lead to more effectively improvement in TCM syndrome, reduce the hematuria, reduce levels of IgA, improve the level of CD4+ and increase C3, reduce the D-dimer values. For the treatment of mild proteinuria, there was no significant difference in the efficacy between the two groups. Conclusions Nourishing yin and clearing blood stasis can effectively alleviate the TCM syndrome, reduce hematuria and proteinuria, regulate immune function, improve the coagulation mechanism in treatment of HSPN children with deficiency of both qi and yin.

参考文献/References:

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相似文献/References:

[1]刘涛.当代名老中医治疗过敏性紫癜性肾炎近5年文献回顾[J].环球中医药,2015,8(10):1275.[doi:10.3969/j.issn.1674.1749.2015.10.041]
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备注/Memo

备注/Memo:
作者简介: 郝静(1972- ),女,硕士,副主任医师。研究方向:小儿常见病的中西医结合诊疗。E-mail:haojing115@sina.com
通讯作者: 闫慧敏(1954- ),女,本科,主任医师,教授,博士生导师。研究方向:小儿常见病的中西医结合诊疗。E-mail:huiminyan@sina.com
更新日期/Last Update: 2016-05-06