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[1]耿彦婷,胡元会,师帅,等.中药干预心肌线粒体内膜能量代谢障碍的疗效:基于动物模型的系统评价[J].环球中医药,2016,9(05):621-627.[doi:10.3969/j.issn.1674-1749.2016.05.030]
　GENG Yan-ting,HU Yuan-hui,SHI Shuai,et al.Efficacy of Chinese herbal medicines in treating myocardial mitochondrial inner membrane energy metabolism disorders: a systematic review based on animal models[J].,2016,9(05):621-627.[doi:10.3969/j.issn.1674-1749.2016.05.030]
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中药干预心肌线粒体内膜能量代谢障碍的疗效:基于动物模型的系统评价()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年05期
页码:
621-627
栏目:
综述
出版日期:
2016-05-06

文章信息/Info

Title:
Efficacy of Chinese herbal medicines in treating myocardial mitochondrial inner membrane energy metabolism disorders: a systematic review based on animal models
作者:
耿彦婷; 胡元会; 师帅; 贾秋蕾
100053 北京,中国中医科学院广安门医院心血管科[耿彦婷(博士研究生)、胡元会、师帅]; 北京中医药大学基础医学院(贾秋蕾)
Author(s):
GENG Yan-ting;  HU Yuan-hui;  SHI Shuai;  et al.
Cardiovascular Department, Guang'anmen Hospital,China Academy of Chinese Medical Sciences, Beijing 100053, China
关键词:
中药;  心肌线粒体;  内膜;  能量代谢障碍;  动物模型;  系统评价
Keywords:
Chinese herbal medicines;  Myocardial mitochondria;  Mitochondrial inner membrane;  Energy metabolism disorders;  Animal models;  Systematic review
分类号:
R285.5
DOI:
10.3969/j.issn.1674-1749.2016.05.030
文献标志码:
A
摘要:
目的 系统评价中药对动物心肌线粒体内膜能量代谢障碍的干预疗效。方法 计算机检索PubMed(1966～2015.7)、Embase(1966～2015.7)、CBM(1978～2015.7)、CNKI(1915～2015.7)、VIP(1989～2015.7)及Wanfang(1990～2015.7)等数据库,纳入中药干预心肌线粒体内膜能量代谢障碍的动物实验,由2名研究者独立评价纳入研究的质量、提取数据并交叉核对,使用RevMan 5.2软件进行Meta分析。结果 共纳入16个研究,系统评价及Meta分析结果显示:中药可提高线粒体态3呼吸速率[P<0.001,I2=0%],增加内膜C I[P<0.0001,I2=0%]、C II[P=0.006,I2=0%]、C IV[P<0.00001,I2=0%]、Cyt c[P<0.0001,I2=40%]活性。结论 中药可通过干预心肌线粒体内膜能量代谢障碍发挥临床疗效,但基于此病理生理机制的中医药研究尚缺乏系统性。
Abstract:
Objective To assess the efficacy of Chinese herbal medicines for myocardial mitochondrial inner membrane energy metabolism disorders based on animal models. Methods We searched PubMed(1966～2015.7),Embase(1966～2015.7),CBM(1966～2015.7),CNKI(1915～2015.7),VIP(1989～2015.7)and Wanfang(1989～2015.7)databases. All researches based on animal models of treating myocardial mitochondrial inner membrane energy metabolism disorders with Chinese herbal medicines versus untreated groups were included. Data were extracted independently by two reviewers. Meta-analyses were conducted by the RevMan 5.2 software. Results Sixteen researches were included. The Meta-analysis results showed that: Chinese herbal medicines could elevate the State 3 respiratory rate of myocardial mitochondria[P<0.001,I2=0%], and up-regulated the activity of ETC CI[P<0.0001,I2=0%],CII[P=0.006,I2=0%],CIV[P<0.00001,I2=0%] and Cyt c[P<0.0001,I2=40%]. Conclusion Chinese herbal medicines may be clinically effective in treating myocardial mitochondrial inner membrane energy metabolism disorders,while the related researches based on this physiopathological mechanism are still lacking systematicness.

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金面上项目(81373833)
作者简介: 耿彦婷(1988- ),女,2013级在读博士研究生。研究方向:中医内科学。E-mail:qiedexfsh@163.com
通讯作者:胡元会(1963- ),博士,主任医师。研究方向:中医治疗心血管疾病。E-mail:huiyuhui55@sohu.com
更新日期/Last Update: 2016-05-06