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[1]赵雯红 田俊丽 杨红源 杨一民 辛海利 孙姗姗 李彦竹 张国瑛.基于血清胱抑素C检测探讨保元胶囊对早期糖尿病肾病患者肾损伤的干预作用[J].环球中医药,2016,9(07):777-781.[doi:10.3969/j.issn.1674-1749.2016.07.001]
　ZHAO Wen-hong,TIAN Jun-li,YANG Hong-yuan,et al.Study on the intervention effect of Baoyuan capsule on early diabetic nephropathy based on detection of serum cystatin C[J].,2016,9(07):777-781.[doi:10.3969/j.issn.1674-1749.2016.07.001]
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基于血清胱抑素C检测探讨保元胶囊对早期糖尿病肾病患者肾损伤的干预作用()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年07期
页码:
777-781
栏目:
论著
出版日期:
2016-07-06

文章信息/Info

Title:
Study on the intervention effect of Baoyuan capsule on early diabetic nephropathy based on detection of serum cystatin C
作者:
赵雯红 田俊丽 杨红源 杨一民 辛海利 孙姗姗 李彦竹 张国瑛
050051 石家庄市中医院肾内科(赵雯红、辛海利、孙姗姗、李彦竹、张国瑛)；石家庄四药有限公司职工医院中医科(田俊丽、杨一民)；保定市第一中心医院骨一科(杨红源)
Author(s):
ZHAO Wen-hong;  TIAN Jun-li;  YANG Hong-yuan; et al.
Renal Department of Internal Medicine, TCM Hospital of Shijiazhuang, Shijiazhuang 050051,China
关键词:
血清胱抑素C; 早期糖尿病肾病; 肾损伤; 保元胶囊
Keywords:
Serum cystatin C; Early diabetic nephropathy; Renal damage; Baoyuan capsule
分类号:
R259
DOI:
10.3969/j.issn.1674-1749.2016.07.001
文献标志码:
A
摘要:
目的 探讨血清胱抑素C对早期筛查糖尿病肾病(diabetic nephropathy,DN)患者肾损伤的意义,及保元胶囊对早期DN的防治作用。方法 选择石家庄市中医院门诊或住院的1～3期DN患者,每期患者随机分为DN中药治疗组和西药对照组,每组各期30例,并选择健康人20例作为正常对照组。治疗3个月后,检测用药前后各组患者血清胱抑素C、尿白蛋白排泄率、血肌酐、内生肌酐清除率水平变化。结果 与1期DN组比较:2期DN组患者血清胱抑素C、血肌酐水平均明显升高(P＜0.05),而尿白蛋白排泄率水平无统计学意义(P＞0.05); 3期DN组患者血清胱抑素C、尿白蛋白排泄率、血肌酐水平均明显升高(P＜0.01),两组内生肌酐清除率水平均明显降低(P＜0.01)。2、3期DN组患者中药治疗后,血清胱抑素C、尿白蛋白排泄率水平均明显降低(P＜0.01),内生肌酐清除率水平均明显升高(P＜0.01); 与西药对照组比较,2、3期DN组患者中药治疗后血清胱抑素C水平明显降低、内生肌酐清除率水平明显升高(P＜0.05)。结论 血清胱抑素C的检测对筛查早期DN患者肾损伤具有重要价值,保元胶囊对早期DN患者肾损伤具有良好的保护作用。
Abstract:
Objective To investigate the meaning of detecting stage 1～3 DN patients serum cystatin C level changes on early screening for diabetic nephropathy(DN)in patients with renal injury, and the prevention effect of Baoyuan capsule on early DN. Methods Stage 1～3 DN patients were chosed from our hospital, the patients were randomly divided into DN treatment group, western medicine control group and normal control group. In the third month, the levels of serum cystatin C, UAER, SCr and Ccr were detected before and after treatments in each group. Results Compared to the stage 1 DN patients, the levels of serum cystatin C and SCr was elevated significantly in the stage 2 DN patients(P＜0.05), but the results of UAER had no significant differences between the two groups(P＞0.05), the levels of serum cystatin C, UAER and SCr were elevated significantly in the stage 3 DN patients(P＜0.01)and the levels of Ccr in stage 2 and stage 3 were significantly decreased(P＜0.01). The levels of serum cystatin C and UAER of the DN patients in the stage 2 and 3were decreased significantly(P＜0.01)and the level of Ccr were significantly improved(P＜0.01)after treatment; compared to the western medicine control group, the levels of serum cystatin C were decreased and Ccr were improved significantly(P＜0.05)in stage 2 and 3 patients after the treatments. Conclusion Detection of serum cystatin C for screening patients with early DN renal injury has important value and Baoyuan capsule has a good protective effect on patients with early DN renal injury.

参考文献/References:

[1] Dabla PK. Renal function in diabetic nephropathy[J]. World J Diabetes,2010,1(2):48-56.
[2] Krolewski AS, Warram JH, Forsblom C, et al. Serum concentration of cystatin C and risk of end-stage renal disease in diabetes[J]. Diabete Care. 2012, 35(11): 2311-2316.
[3] Rosolowsky ET,Niewczas MA,Ficociello LH,et al.Between hyperfiltration and impairment:Demystifying early renal functional changes in diabetic nephropathy[J].Diabetes research and clinical practice,2008,82:46-53.
[4] Wang T, Wang Q, Wang Z, et al. Diagnostic value of the combined measurement of serum hcy, serum cystain C, and urinary microalbumin in type 2 diabetes mellitus with early complicating diabetic nephropathy[J]. ISRN Endocrinol, 2013,9:1-5
[5] Assal HS, Tawfeek S, Rasheed EA, et al. Serum cystatin cand tubular urinary enzymes as biomarkers of renal dysfunction in type 2 diabetes mellitus[J]. Clin Med Insights Endocrinol Diabetes,2013, 6(7):7-13.
[6] Chae HW, Shin JI, Kwon AR, et al. Spot urine albumin to creatinine ratio and serum cystatin C are effective for detection of diabetic nephropathy in childhood diabetic patients[J]. J Korean Med Sci,2012,27(7):784-787.
[7] 李青,张国瑛,闫慧明,等.保元胶囊治疗糖尿病肾病的临床研究[J].中华中医药杂志,2006,21(11):685-686.
[8] 李青,张鹤,丁振华,等.保元Ⅱ号对糖尿病大鼠肾脏中Smad蛋白表达的影响[J].中华中医药杂志,2009,24(3):370-372.

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备注/Memo

备注/Memo:
基金项目: 石家庄市科学技术研究与发展指导计划(12146893)
作者简介: 赵雯红(1980- ),女,博士,副主任医师。研究方向:肾脏病的临床及实验研究。E-mail:zwhhrc@163.com
更新日期/Last Update: 2016-07-06