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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第9卷

期数:

2016年07期

页码:

891-895

栏目:

综述

出版日期:

2016-07-06

文章信息/Info

Title:

Review on new technologies and methods of pharmacokinetics of traditional Chinese medicines in recent 10 years

作者:

柏冬 王瑞海 刘丽梅

100700 北京,中国中医科学院中医基础理论研究所

Author(s):

BAI Dong;  WANG Rui-hai;  LIU Li-mei.

Institute of Basic Theory of TCM, China Academy of Chinese Medical Sciences, Beijing 100700, China

关键词:

中药药代动力学; 中药多组分整合药代动力学; 中药药代标记物; 代谢组学

Keywords:

Pharmacokinetics of traditional Chinese medicines; Integral pharmacokinetic study of multiple components; Pharmacokinetic markers of traditional Chinese medicine; Metabonomics

分类号:

R285.5

DOI:

10.3969/j.issn.1674-1749.2016.07.040

文献标志码:

A

摘要:

中药具有多成分、药效物质不确切的特征,长期以来中药药代动力学的研究存在许多困难。新的仪器、分析技术的出现,提高了中药体内成分分析的灵敏度,使得中药多成分药代研究成为可能。目前认为,在中药药代动力学研究中同时监测多个成分的药代动力学特征是十分有必要的,“中药多组分整合药代动力学研究”“中药药代标记物”“代谢组学”的研究思路较好地解决了这个问题。但目前的研究仍然存在许多争议,本文对近十年中药药代动力学的新技术与新方法进行综述,希望对中药药代动力学研究提供借鉴。

Abstract:

As the chemical compositions in traditional Chinese medicine is very complex and the effective components are not accurate,there are many difficulties in the study of traditional Chinese medicine. With the developments of new technologies and methods,a lot of achievements in the pharmacokinetics have been made at home. For example, the emergence of new instruments and analysis technology can improve the sensitivity of the analysis the composition of traditional Chinese medicine in vivo, and make it possible to study the composition of traditional Chinese medicine. It has been reached an agreement that monitoring multi-components' pharmacokinetics characteristic at the same time is very necessary. The research idea of “integral pharmacokinetic study of multiple components”, “pharmacokinetic markers of traditional Chinese medicine” and “metabonomics technology” can resolve this problems,but there are still of a lot of controversy in the present study. This paper organizes the related literature with pharmacokinetics of traditional Chinese medicine in recent 10 years. We hope it can provide reference for the study of pharmacokinetics of traditional Chinese medicines.

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备注/Memo

备注/Memo:

基金项目: 国家重点基础研究发展计划(973计划)(2012CB518401)
作者简介: 柏冬(1983- ),博士,副研究员。研究方向:中药药效物质基础。E-mail:baidong2000@126.com
通讯作者: 刘丽梅(1965- ),女,本科,研究员。研究方向:中医方证基础研究。E-mail:liulimeihrb@163.com

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更新日期/Last Update: 2016-07-06