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[1]黄弥娜,曹青青,李云青,等.瑞香狼毒毒性部位的化学成分研究[J].环球中医药,2016,9(09):1059-1064.[doi:10.3969/j.issn.1674-1749.2016.09.007]
　HUANG Mi-na,CAO Qing-qing,LI Yun-qing,et al.Study on chemical constituents of toxicity parts in Stellera chamaejasme L.[J].,2016,9(09):1059-1064.[doi:10.3969/j.issn.1674-1749.2016.09.007]
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瑞香狼毒毒性部位的化学成分研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年09期
页码:
1059-1064
栏目:
论著
出版日期:
2016-09-06

文章信息/Info

Title:
Study on chemical constituents of toxicity parts in Stellera chamaejasme L.
作者:
黄弥娜; 曹青青; 李云青; 费扬; 李洋; 李盛建; 吕磊; 赵亮
200438 上海,中国人民解放军第二军医大学东方肝胆外科医院药材科
Author(s):
HUANG Mi-na; CAO Qing-qing; LI Yun-qing; et al.
Department of Pharmacy,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China
关键词:
瑞香狼毒;  毒性部位;  化学成分
Keywords:
Stellera chamaejasme L.;  Toxic part;  Chemical constituents
分类号:
R284
DOI:
10.3969/j.issn.1674-1749.2016.09.007
文献标志码:
-
摘要:
目的 研究瑞香狼毒的毒性部位及毒性部位的化学成分。方法 通过小鼠急性毒性实验筛选出瑞香狼毒的毒性部位,采用多种色谱技术分离毒性部位提取物,并根据化合物的理化性质和光谱数据分析鉴别单体化合物的结构。结果 确定乙酸乙酯极性部位为狼毒毒性部位,在乙酸乙酯部位中分离得到12个化合物,分别鉴定为:Epiafzelechin(1)、Scopoletin(2)、Isolariciresinol(3)、Lirioresinol B(4)、Stelleranol(5)、Daphnoretin(6)、Chamaechromone(7)、Neochamaejasmin A(8)、Chamaejasmine(9)、Isochamaejasmin(10)、7-methoxyneochamaejasmin A(11)及Matairesinol(12)。结论 本文首次报道了瑞香狼毒的毒性部位研究,并分离鉴定毒性部位的化学成分。
Abstract:
Objective To isolate and identify the compounds of the toxic part from the Stellera chamaejasme L. Methods Toxic part of the Stellera chamaejasme L. was screened by acute toxicity,the compounds were separated and purified by chromatographic technique and their structures were established by spectroscopic methods. Results The toxicity part of the Stellera chamaejasme L. was the polar parts of ethyl acetate,and twelve compounds were obtained from ethyl acetate extracts of the Stellera chamaejasme L.,which were identified as Epiafzelechin(1), Scopoletin(2), Isolariciresinol(3), Lirioresinol B(4), Stelleranol(5), Daphnoretin(6), Chamaechromone(7), Neochamaejasmin A(8), Chamaejasmine(9), Isochamaejasmin(10), 7-methoxyneochamaejasmin A(11)and Matairesinol(12). Conclusion This is the first report of the toxicity of polar fractions of Stellera chamaejasme L.,separate and identify the chemical composition of the toxicity of polar parts.

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金-青年项目(81303300)
作者简介: 黄弥娜(1981- ),女,本科,药师。研究方向:中药质量控制。E-mail:huangmina1981@163.com
通讯作者: 赵亮(1980- ),博士,副主任药师。研究方向:中药药效物质基础及新药开发。E-mail:zhaoliangphar@163.com
更新日期/Last Update: 2016-09-06