|本期目录/Table of Contents|

[1]冒慧敏,刘秀华,史大卓.桃红四物汤治疗冠心病的机制研究进展[J].环球中医药,2016,9(09):1145-1148.[doi:10.3969/j.issn.1674-1749.2016.09.039]
　MAO Hui-min,LIU Xiu-hua,SHI Da-zhuo..Research progress on the mechanism of Taohong Siwu decoction in the treatment of coronary atherosclerotic heart disease[J].,2016,9(09):1145-1148.[doi:10.3969/j.issn.1674-1749.2016.09.039]
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桃红四物汤治疗冠心病的机制研究进展()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年09期
页码:
1145-1148
栏目:
综述
出版日期:
2016-09-06

文章信息/Info

Title:
Research progress on the mechanism of Taohong Siwu decoction in the treatment of coronary atherosclerotic heart disease
作者:
冒慧敏; 刘秀华; 史大卓
100029 北京中医药大学研究生院[冒慧敏(博士研究生)]; 中国中医科学院心血管病研究所[冒慧敏(博士研究生)、史大卓]; 中国人民解放军总医院病理生理研究室(刘秀华)
Author(s):
MAO Hui-min;  LIU Xiu-hua;  SHI Da-zhuo.
Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
桃红四物汤;  冠心病;  临床研究;  机制
Keywords:
Taohong Siwu decoction;  Coronary atherosclerotic heart disease;  Clinical trials;  Mechanism
分类号:
R541.4
DOI:
10.3969/j.issn.1674-1749.2016.09.039
文献标志码:
-
摘要:
桃红四物汤是活血化瘀的常用方之一,近年来被广泛用于治疗冠心病。研究表明,桃红四物汤可改善冠心病患者的心绞痛症状及心电图缺血的表现,其机制可能与减轻心肌细胞损伤、改善内皮细胞功能、抑制血管平滑肌细胞增殖和迁移、抑制血小板聚集和活化、抑制炎症反应、改善血脂代谢相关。但纵观桃红四物汤对冠心病的机制研究,仍存在一定的局限性,应进一步明确其治疗冠心病的分子生物学作用机制,开展高质量的随机对照研究,以期为桃红四物汤治疗冠心病的临床应用提供依据。
Abstract:
Taohong Siwu decoction is the commonly-used prescription for promoting blood circulation and removing blood stasis,and the prescription has been widely used in coronary atherosclerotic heart disease(CAHD). It is reported that Taohong Siwu decoction can relieve angina symptoms and improve electrocardiogram(ECG). The possible mechanisms may be related to reducing myocardial cell damage, improving endothelial function, inhibiting the proliferation and migration of vascular smooth muscle cells, inhibiting platelet aggregation and activation, inhibiting inflammatory reaction and improving blood lipid metabolism. However,there are several limitations of the relevant articles. More researches should be conducted on the mechanisms and clinical effects of Taohong Siwu decoction for CAHD patients,to provide evidence for clinical application of Taohong Siwu decoction.

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备注/Memo

备注/Memo:
基金项目: 国家重点基础研究发展计划(973计划)(2015CB554402); 国家“十二五”科技支撑计划(2013BAI02B01)
作者简介: 冒慧敏(1989- ),女,2014级在读博士研究生。研究方向:中西医结合治疗心血管病。E-mail:maomolly@sina.com
通讯作者: 刘秀华(1957- ),女,博士,研究员,博士生导师。研究方向:病理与病理生理学。E-mail:xiuhualiu98@163.com; 史大卓(1960- ),博士,研究员,博士生导师。研究方向:中西医结治疗合心血管病。E-mail:shidazhuo@126.com
更新日期/Last Update: 2016-09-06