|本期目录/Table of Contents|

[1]郭雨菲,李雪,迟莉.中药单体抗肝纤维化作用研究进展[J].环球中医药,2016,9(09):1149-1152.[doi:10.3969/j.issn.1674-1749.2016.09.040]
　GUO Yu-fei,LI Xue,CHI Li..Research advance on the effect of Chinese medicine monomer on anti-hepatic fibrosis[J].,2016,9(09):1149-1152.[doi:10.3969/j.issn.1674-1749.2016.09.040]
点击复制

中药单体抗肝纤维化作用研究进展()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年09期
页码:
1149-1152
栏目:
综述
出版日期:
2016-09-06

文章信息/Info

Title:
Research advance on the effect of Chinese medicine monomer on anti-hepatic fibrosis
作者:
郭雨菲; 李雪; 迟莉
100069 北京,首都医科大学中医药学院[郭雨菲(本科生)、李雪、迟莉]
Author(s):
GUO Yu-fei;  LI Xue;  CHI Li.
Major of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Capital Medical University,Beijing 100069, China
关键词:
肝纤维化;  中药单体;  作用机制
Keywords:
Hepatic fibrosis;  Chinese medicine monomer;  Mechanism
分类号:
R285
DOI:
10.3969/j.issn.1674-1749.2016.09.040
文献标志码:
-
摘要:
本文通过查阅近几年国内外相关文献,对较为新颖的10种中药单体抗肝纤维化的作用及机制进行分析和综述。这10种单体包括橙皮苷、羟基红花黄色素A、灯盏花素、番茄红素、甲基莲心碱、木犀草素、青蒿琥酯、人参皂苷Rg1、人参皂苷Rb1、红景天苷,经分析,这10种中药单体作用特点各有不同,但对肝纤维化均具有一定的治疗效果; 目前对这些中药单体的研究以药效学为主,机制的研究还较少。本文可为未来治疗肝纤维化的新药研发方向提供参考。
Abstract:
This paper is to review the recent research progress in domestic and abroad of Chinese medicine monomer for the treatment of liver fibrosis. The effect and mechanism of 10 kinds of traditional Chinese herbal medicine on hepatic fibrosis are analyzed and summarized. The monomer including Hesperidin, Hydroxysafflor yellow A, Breviscapine, Lycopene, Nerefine, Luteolin, Artesunate, Ginsenoside Rg1, Ginsenoside Rb1 and Salidroside. The ten kinds of Chinese medicine monomer have their unique characteristics and all have certain effectin the treatment of liver fibrosis. At present, the study on the Chinese medicine monomer is mainly based on pharmacodynamics, but the mechanism is still less. This paper can provide reference for the future development of new drugs for the treatment of liver fibrosis.

参考文献/References:

[1] Elshazly SM, Mahmoud AA. Antifibrotic activity of hesperidin against dimethylnitrosamine -induced liver fibrosis inrats[J]. Naunyn-schmiedebergs archives of pharmacology,2014, 387(6): 559-567.
[2] Pérez-Vargas JE, Zarco N, Shibayama M,et al. Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-β and connective tissue growth factor[J]. Pharmacology,2014, 94(1-2): 80-89.
[3] Xiang Lin, Ling-Na Kong, Cheng Huang,et al. Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/β-catenin pathway[J]. Immunopharmacol,2015, 25(2): 311-320.
[4] 王艺蓉, 李雅娜, 李京敏,等. 羟基红花黄色素A对肝纤维化大鼠血清学指标及脂质过氧化的影响[J]. 四川解剖学杂志, 2011, 19(1): 1-4.
[5] 李红星, 王东, 时彦,等. 羟基红花黄色素A对实验性大鼠肝纤维化TGF-β1-CTGF的影响[J]. 中华临床医师杂志(电子版), 2014, 8(4): 652-655.
[6] 王银辉, 耿玲, 李辉. 灯盏乙素抗大鼠肝纤维化作用的研究[J]. 中国中药杂志, 2015, 40(10): 1999-2003.
[7] 孟庆媛, 苏亚楠, 郭梦凡,等. 灯盏花素对肝纤维化模型大鼠MMP-13及TIMP-1表达的研究[J]. 黑龙江医药科学, 2013, 36(3): 96-97.
[8] 林明华, 孟庆媛, 郭梦凡. 灯盏花素干预大鼠肝星状细胞Caspase-3、NF-κB表达的研究[J]. 黑龙江医药科学, 2012, 35(5): 46-48.
[9] Kitade Y, Watanabe S, Masaki T, et al. Inhibition of liver fibrosis in LEC rats by a carotenoid, lycopene, or a herbal medicine, Sho-saiko-to[J]. Hepatol Research,2002, 22(3): 196-205.
[10] 赵凯. 番茄红素对小鼠肝纤维化的保护作用[J]. 江苏大学学报(医学版), 2014, 24(4): 290-293.
[11] 张楠楠, 陶瑾, 姜民,等. 番茄红素对四氯化碳致小鼠急性肝损伤的保护作用[J]. 现代药物与临床, 2013, 28(1): 14-17.
[12] Chen MS, Zhang JH, Wang JL, et al. Anti-fibrotic effects of neferine on carbon tetrachloride- induced hepatic fibrosis in mice[J]. Am J Chin Med,2015, 43(2): 231-240.
[13] Ding H, Shi J,Wang Y, et al. Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: A possible molecular mechanism[J]. Eur J Pharmacol,2011, 650(1): 163-169.
[14] Domitrovic' R, Jakovac H, Tomac J, et al. Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin[J].Toxicol Appl Pharmacol,2009, 241(3): 311-321.
[15] Li J, Li X, Xu W, et al. Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways[J].Liver Int,2015, 35(4): 1222-1233.
[16] 李星霞, 李婕, 王绍展,等. 木犀草素对肝纤维化进程中肝细胞上皮间质转化的抑制作用[J]. 中国药房, 2014, 25(19): 1729-1732.
[17] Xu Y, Liu W, Fang B, et al. Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases[J]. Eur J Pharmacol,2014, 744: 1-9.
[18] 张晓燕,马淑晶,徐亚洁,等. 青蒿琥酯对人源肝星状细胞LX-2增殖、胶原产生以及KLF6表达的影响[J]. 天津医科大学学报,2014, 20(4): 257-259.
[19] 张晓勇,周春祥. 青蒿琥酯对大鼠肝Kupffer细胞分泌肝纤维化相关细胞因子的影响[J]. 安徽医学,2014, 35(10): 1437-1439.
[20] Li JP, Gao Y, Chu SF, et al. Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis[J]. Acta Pharmacol Sin,2014, 35(8):1031-1044.
[21] Geng J, Peng W, Huang Y, et al. Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats[J]. European Journal of Pharmacology,2010, 634(1-3): 162-169.
[22] 李剑瑜, 刘鹏年, 张霞,等. 三七皂苷Rg1对肝纤维化大鼠线粒体质子跨膜转运的作用机制[J]. 环球中医药,2015, 8(5): 523-526.
[23] 董向前, 段丽平, 梁兵,等. 人参皂苷Rg1和Rb1抗肝纤维化的体视学研究[J]. 山东大学学报(医学版), 2012, 43(27): 3599-3616.
[24] YL Hou, YH Tsai,YH Lin, et al. Ginseng extract and ginsenoside Rb1 attenuate carbon tetrachloride-induced liver fibrosis in rats[J]. BMC Complement Altern Med,2014, 14(1): 1-11.
[25] Lo YT, Tsai YH, Wu SJ, et al. Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells[J]. J Med Food,2011, 14(10): 1135-1143.
[26] 陈磊. 红景天苷抗肝纤维化:涉及ROS相关的TGF-β1,NF-κB,MMPs/TIMPs及NO通路[D]. 兰州:兰州大学, 2013.
[27] Ouyang J,Gao Z, Ren Z, et al. Synergistic effects of rMSCs and salidroside on the experimental hepatic fibrosis[J]. Pharmazie, 2010, 65(8): 607-613.
[28] 殷鹏昌. 红景天苷和沙棘黄酮对乙醛诱导肝星状细胞增殖的影响[D].西宁:青海大学,2014.
[29] 张展,徐列明. 红景天苷抑制肝星状细胞迁移的作用机制研究[C]//第二届国际中西医结合肝病学术会议论文汇编,2010: 3.
[30] Christian Trautwein, Scott L. Friedman, Detlef Schuppan, et al. Hepatic fibrosis: Concept to treatment[J]. Journal of Hepatology, 2015, 62(1): 15-24.

相似文献/References:

[1]徐晨光 闫洁 陈蓝羽 李娟梅 吕文良.丹参有效成分抗肝纤维化作用机制的研究进展[J].环球中医药,2013,6(04):305.
　XU Chen guang,YAN Jie,CHEN Lan yu,et al.Research progress in antihepatic fibrosis mechanism of Salvia Miltiorrhiza[J].,2013,6(09):305.
[2]李川,吕文良.常见中药复方制剂抗肝纤维化机制研究进展[J].环球中医药,2013,6(01):70.
　LI Chuan,LYU Wen liang..Mechanism research of common Chinese patent medicine antifibrotic[J].,2013,6(09):70.
[3]刘文兰 油红捷 车念聪等.一贯煎促进骨髓间充质干细胞逆转肝纤维化的实验研究[J].环球中医药,2014,7(06):401.
　LIU Wen lan,YOU Hong jie,CHE Nian cong,et al.The promotion of Yiguanjian on the recovery of liver fibrosis through mesenchymal stem cells:an experimental study[J].,2014,7(09):401.
[4]李剑瑜 刘鹏年 张霞等.三七皂甙Rg1、Rb1对肝纤维化大鼠线粒体DNA三磷酸腺苷酶6、8亚基的作用机制研究[J].环球中医药,2014,7(08):591.
　LI Jian-yu,LIU Peng-nian,ZHANG Xia,et al.Study on the mitochondrial mtDNA ATPase6、8 gene mutation and on the function mechanism of panax notoginseng saponins Rg1,Rb1 for hepatic fibrosis rats[J].,2014,7(09):591.
[5]李剑瑜,刘鹏年,张霞,等.三七皂苷Rg1对肝纤维化大鼠线粒体质子跨膜 转运的作用机制[J].环球中医药,2015,8(05):523.[doi:10.3969/j.issn.16741749.2015.05.003]
　LI Jian yu,LIU Peng nian,ZHANG Xia,et al.Action mechanism of proton translocation across mitochondrial membrane of notoginsenoside Rg1 on hepatic fibrosis rats[J].,2015,8(09):523.[doi:10.3969/j.issn.16741749.2015.05.003]
[6]王磊,王惠娟,吴凯,等.茵陈蒿汤改善酒精性肝病大鼠肝脏及小肠病变的组织病理学研究[J].环球中医药,2015,8(11):1329.[doi:10.3969/j.issn.1674-1749.2015.11.014]
　WANG Lei,WANG Hui juan,WU Kai,et al.Effect of Yinchenhao decoction on both hepatic and intestinal histopathology in rats with alcoholic liver disease[J].,2015,8(09):1329.[doi:10.3969/j.issn.1674-1749.2015.11.014]
[7]马羽萍 吴超 王裕云 姚海波.芪归四逆散联合恩替卡韦分散片治疗肝郁脾虚血瘀型慢性乙型肝炎肝纤维化48例[J].环球中医药,2016,9(07):862.[doi:10.3969/j.issn.1674-1749.2016.07.031]

备注/Memo

备注/Memo:
基金项目: 首都中医药研究专项基金(ZM08); 首都医科大学2015年度本科生科研创新项目
作者简介: 郭雨菲(1995- ),女,2014级在读本科生。研究方向:中医基础理论。E-mail:654714030@qq.com
通讯作者: 迟莉(1980- ),女,博士,讲师。研究方向:肝脏疾病文献和实验研究。E-mail:13911824903@163.com
更新日期/Last Update: 2016-09-06