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[1]李如意 宋厚盼 魏艳霞 余黄合 李鑫 蔡雄 黄惠勇 刘平安.冬虫夏草药理作用的研究进展[J].环球中医药,2016,9(10):1284-1288.[doi:10.3969/j.issn.1674-1749.2016.10.042]
　LI Ru-Yi,SONG Hou-Pan,WEI Yan-Xia,et al.Research advances of pharmacological activities of Cordyceps[J].,2016,9(10):1284-1288.[doi:10.3969/j.issn.1674-1749.2016.10.042]
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冬虫夏草药理作用的研究进展()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年10期
页码:
1284-1288
栏目:
综述
出版日期:
2016-10-06

文章信息/Info

Title:
Research advances of pharmacological activities of Cordyceps
作者:
李如意 宋厚盼 魏艳霞 余黄合 李鑫 蔡雄 黄惠勇 刘平安
410007 长沙,湖南中医药大学中医诊断学湖南省重点实验室[李如意(硕士研究生)、宋厚盼、魏艳霞、余黄合、李鑫、蔡雄、黄惠勇、刘平安]; 湖南中医药大学药学院[李如意(硕士研究生)、余黄合、刘平安]
Author(s):
LI Ru-Yi; SONG Hou-Pan; WEI Yan-Xia; et al.
Hunan Provincial Key Laboratory of Diagnostic and Therapeutic Research in Chinese Medicine,Changsha 410208,China
关键词:
冬虫夏草;  药理作用;  综述
Keywords:
Cordyceps;  Pharmacological action;  Review
分类号:
R284
DOI:
10.3969/j.issn.1674-1749.2016.10.042
文献标志码:
A
摘要:
冬虫夏草是冬虫夏草菌子实体和幼虫尸体的结合体,是中国传统的珍稀名贵药材,具有益肺肾、补精髓之功效。其化学成分主要包含多糖、核苷酸、甾醇等,具备多种药理作用,因对人体健康具有极大的价值而备受国内外学者关注。本文主要综述了冬虫夏草的药理作用,并展望了冬虫夏草的应用前景。
Abstract:
Cordyceps sinensis is a combination of Cordyceps sinensis fruitbody and larva body of Cordyceps sinensis(Berk.)Sacc. As a rare and valuable herb in Chinese medicine, it has been medicinally used for lung and kidney tonic and replenishing essence. Cordyceps mainly consists of polysaccharides, nucleosides and sterols, and has a variety of pharmacological activities. Cordyceps has attracted much attention of the scholars at home and abroad because of the great value to human health. Here we summarize the research advances on the pharmacological effect of cordycepsin in recent years, and looks ahead the application prospect of Cordyceps sinensis.

参考文献/References:

[1] 武丽斐,邢月,关亚兰,等.冬虫夏草有效成分及其药理作用的研究进展[J]. 中西医结合心脑血管病杂志,2013,11(10):1254-1256.
[2] 国家药典委员会. 中华人民共和国药典(一部)[M].9版. 北京:中国科技出版社,2010:106.
[3] 詹小涛,赖桂萍,朱德霞. 冬虫夏草及其发酵菌丝体药理作用研究进展[J]. 医学综述,2012,18(10):1566-1569.
[4] 肖建辉,李彦,肖瑜,等. 虫草属真菌的生物活性及机制研究现状与展望[J]. 中国中药杂志,2013,38(5):640-647.
[5] 宁晓玲. 聚焦玉树“软黄金”—冬虫夏草[J]. 中国现代中药,2010,12(5):39-42.
[6] Wang M,Meng XY,Yang RL,et al. Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice[J]. Carbohydr Polym,2012,89(2):461-466.
[7] 祝希媛,史勇,刘晓明,等. 人工培养冬虫夏草菌粉对细胞免疫的抑制作用[J]. 中西医结合杂志,1990,10(8):485-487.
[8] 龚晓健,季晖,卢顺高, 等. 人工虫草多糖对小鼠免疫功能的影响[J]. 中国药科大学学报,2000,31(1):53-55.
[9] 钟建春,张艳,丁振涛,等. 人工冬虫夏草多糖提取物对小鼠免疫功能的影响[J]. 中山大学学报(自然科学版),2011,50(6):100-102.
[10] Sheng L,Chen J,Li J,et al. An exopolysaccharide from cultivated Cordyceps sinensis and its effects on cytokine expressions of immunocytes[J]. Appl Biochem Biotechnol,2011,163(5):669-678.
[11] 余洪磊,周巧玲,黄仁发,等. 冬虫夏草对大鼠肾缺血再灌注模型肾组织HIF-1α及NGAL表达的影响[J]. 中南大学学报(医学版),2012,37(1):57-66.
[12] 郑丰,田劲,黎磊石. 冬虫夏草对肾毒性急性肾功能衰竭的疗效及机制探讨[J]. 中国中西结合杂志,1992,12(5):288-291.
[13] 张明辉,潘明明,倪海峰,等. 冬虫夏草菌粉对 5 / 6 肾大部切除大鼠肾脏氧化应激及线粒体功能的影响[J]. 中国中西医结合杂志,2016,35(4):443-449.
[14] 公伟,刘丹,岳会敏,等. 冬虫夏草菌丝体提取物抑制顺铂诱导的肾小管上皮细胞损伤[J]. 中国免疫学杂志,2016,32(5):669-672.
[15] Pan MM,Zhang MH,Ni HF,et al. Inhibition of TGF-b1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats[J]. Foodand Chemical Toxicology,2013,58:487-494.
[16] 顾刘宝,卞茸文,涂玥,等. 虫草素调控eIF2α/TGF-β/Smad信号通路改善肾间质纤维的机制[J]. 中国中药杂志,2014,39(21):4096-4101.
[17] Ding C,Tian PX,Xue W,et al. Efficacy of Cordyceps sinensis in long term treatment of renal transplant patients[J]. Front Biosci(Elite Ed),2011,3:301-307.
[18] Zhang Z,Wang X,Zhang Y,et al. Effect of Cordyceps sinensis on renal function of patients with chronic allograft nephropathy[J]. Urol Int,2011,86(3):298-301.
[19] 孙艳,孙艳影,杜凤霞. 冬虫夏草精粉抗肿瘤作用的实验研究[J]. 中华中医药学刊,2007,25(10):2171-2172.
[20] Sato A,Yoshikawa N,Kubo E,et al. Inhibitory effect of cordycepin on B16-F0 mouse melanoma cells[J]. In Vivo,2013,27(6):729-732.
[21] Yao WL,Ko BS,Liu TA,et al. Cordycepin suppresses integrin/FAK signaling and epithelial-mesenchymal transition in hepatocellularcarcinoma[J].Anticancer Agents Med Chem,2014,14(1):29-34.
[22] 张淑兰,孙云汉,刘晓平,等. 冬虫夏草及人工虫草菌丝杭小鼠Lewis肺癌的研究[J]. 中药通报. 1987,12(2):53-54.
[23] Tao X,Ning Y,Zhao X,et al.The effects of cordycepin on the cell proliferation,migration and apoptosis in human lung cancer cell lines A549 and NCI-H460[J].J Pharm Pharmacol,2016,68(7):901-911.
[24] Kang FC,Chen PJ,Pan BS,et al. Apoptotic effect cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells[J]. Onco Targets Ther,2015,8:2345-2360.
[25] Pan BS,Lin CY,Huang BM. The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leyding Toumor Cells[J]. Evid Based Complement Alternat Med,2011:750468.
[26] Song D,Lin J,Yuan F,et al. Ex vivo stimulation of murine dendritic cells by an exopolysaccharide from one of the anamorph of Cordyceps sinensis[J]. Cell Biochem Funct,2011,29(7):555-561.
[27] Kim HS,Kim JY,Ryu HS,et al. Phenotypic and functional maturation of dendritic cells induced by polysaccharide isolated from Paecilomyces cicadae[J]. J Med Food,2011,14(7-8):847-856.
[28] 李绍平,季晖,李萍,等. 冬虫夏草抗肿瘤作用研究进展[J]. 中草药,2001,32(4):373-375.
[29] Kan WC,Wang HY,Chien CC,et al. Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus[J]. Evid Based Complement Alternat Med:743107.
[30] Ma L,Zhang S,Du M. Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice[J]. Nutr Res,2015,35(5):431-439.
[31] El ZZEAF,Mahmoud MF,El MNN,et al. Effect of Cordyceps sinensis and taurine either alone or in combination on streptozotocin induced diabetes[J]. Food Chem Toxicol,2012,50(3-4):1159-1165.
[32] Park JM,Lee JS,Lee KR,et al. Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence[J]. Nutrients,2014,6(9):3711-3726.
[33] Zou Y,Liu Y,Ruan M,et al. Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly,Drosophila melanogaster,by inhibiting oxidative stress[J]. Int J Mol Med,2015,36(4):939-946.
[34] Li XT,Li HC,Li CB,et al. Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris[J]. Am J Chin Med,2010,38(6):1093-1106.
[35] 管彩虹,刘进. 冬虫夏草对COPD模型大鼠肺功能及Th1/ Th2的影响[J]. 浙江中西医结合杂志,2008,18(6):334-337.
[36] Zhang DW,Wang ZL,Qi W,et al. The effects of Cordyceps sinensis phytoestrogen on estrogen deficiency-induced osteoporosis in ovariectomized rats[J]. BMC Complement Altern Med,2014,14:484.
[37] 郑兵,谢芳一,蔡国辉,等. 雪峰虫草对DC-CIK增殖及HepG-2细胞杀伤作用的实验研究[J]. 中国免疫学杂志,2015,31(2):189-192.

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备注/Memo

备注/Memo:
基金项目: 湖南省科技重大专项(2014FJ1007); 湖南省高层次卫生人才“225”工程医学学科骨干人才培养对象项目; 湖南省教育厅优秀青年项目(15B179); 湖南中医药大学方剂学省级重点学科开放基金(2015-02); 湖南中医药大学博士科研启动项目(1001-017)
作者简介: 李如意(1993- ),女,2015级在读硕士研究生。研究方向:中药药效物质基础研究。E-mail:171686119@qq.com
通讯作者: 黄惠勇(1963- ),博士,教授,博士生导师。研究方向:中医病证诊断规范及信息处理研究。E-mail:huanghy@hnctcm.edu.cn; 刘平安(1972- ),博士,副教授。研究方向:中药药效物质基础与质量控制研究。E-mail:liupa@hnctcm.edu.cn
更新日期/Last Update: 2016-10-06