|本期目录/Table of Contents|

[1]滕会会 杜守颖 李鹏跃 陆洋 白洁 武慧超 孙如煜 张晴 杜秋.基于中药指纹图谱结合模式识别的清开灵软胶囊批次间稳定性控制研究[J].环球中医药,2016,9(11):1322-1327.[doi:10.3969/j.issn.1674-1749.2016.11.010]
　TENG Hui-hui,DU Shou-ying,LI Peng-yue,et al.Based on fingerprint combined with chemical pattern recognition for stability control study between different batches of Qingkailing soft capsules[J].,2016,9(11):1322-1327.[doi:10.3969/j.issn.1674-1749.2016.11.010]
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基于中药指纹图谱结合模式识别的清开灵软胶囊批次间稳定性控制研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年11期
页码:
1322-1327
栏目:
论著
出版日期:
2016-11-06

文章信息/Info

Title:
Based on fingerprint combined with chemical pattern recognition for stability control study between different batches of Qingkailing soft capsules
作者:
滕会会 杜守颖 李鹏跃 陆洋 白洁 武慧超 孙如煜 张晴 杜秋
100102 北京中医药大学中药学院[滕会会(硕士研究生)、杜守颖、李鹏跃、白洁、陆洋、武慧超、孙如煜(硕士研究生)、张晴(硕士研究生)、杜秋(硕士研究生)]
Author(s):
TENG Hui-hui; DU Shou-ying; LI Peng-yue; et al.
School of Chinese Pharmacy,Beijing University of TCM,Beijing 100102,China
关键词:
指纹图谱;  化学模式识别;  清开灵软胶囊
Keywords:
Fingerprint;  Chemical pattern recognition;  Qingkailing soft capsules
分类号:
R284
DOI:
10.3969/j.issn.1674-1749.2016.11.010
文献标志码:
A
摘要:
目的 基于中药指纹图谱结合化学模式识别方法寻找影响清开灵软胶囊批次间稳定性的重点化学成分。方法 采用聚类分析、主成分分析及偏最小二乘法模型对不同批次清开灵软胶囊的高效液相色谱法指纹图谱进行整体观察和评价,找出可能与相似度强相关的标志物。结果 通过系统聚类分析及主成分分析表明剔除黄芩苷色谱峰后的相似度计算结果更符合实际情况; 经偏最小二乘法分析得到3个化学成分与相似度密切相关,该3个化合物可作为控制清开灵软胶囊批次间稳定性的重点化学成分。结论 该中药指纹图谱-化学模式识别方法用于中药不同批次间稳定性控制研究是可行的。
Abstract:
Objective Based on fingerprint combined with chemical pattern recognition method for Qingkailing soft capsule on the stability of key chemical composition between different batches. Methods Cluster analysis, PCA and PLS model were used for observation and evaluation of different batches of soft capsules on the HPLC fingerprint, markers associated with similarity were identified. Results The system clustering analysis and principal component analysis showed that after eliminating chromatographic peak of baicalin similarity calculation the results was more in line with the actual situation. The PLS analysis was got 3 chemical component that was closely related to the similarity. The three compounds can be used as a key of chemical composition which influenced the stability of soft capsule between different batches. Conclusion The TCM fingerprint and chemical pattern recognition method is feasible for traditional Chinese medicine(TCM)between different batches stability control research.

参考文献/References:

[1] 唐卡毅. 清开灵软胶囊临床应用与研究新进展[J]. 现代中西医结合杂志,2009,18(12):1444-1447.
[2] 陈荣,李云委. 清开灵临床应用概况[J]. 江西中医学院学报,1995,7(1):42-44.
[3] 国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2015:1526-1528.
[4] 梁逸曾,易伦朝,黄熙,等. 中药分析新思路及其质量控制[J]. 分析测试学报,2014,33(2):119-126.
[5] 孙磊,乔善义,赵毅民. 中药指纹图谱应用研究进展[J]. 国际药学研究杂志,2009,36(3):194-197,203.
[6] 徐小娜. 中药色谱指纹图谱研究及化学计量学方法的应用[D].长沙:中南大学,2010.
[7] 黎阳,刘素香,张铁军,等. 枳实的高效液相色谱指纹图谱研究[J]. 中草药,2009,40(9):1469-1474.
[8] 刘潇潇,周颖仪,杨立伟,等. 清开灵系列制剂的氨基酸色谱指纹图谱[J]. 中成药,2014,36(12):2537-2542.
[9] Liu Z H,Ting xiang Y E,Zhao H Z,et al. Fingerprint and chemical pattern recognition method for quality control of Huoxiang Zhengqi liquid[J]. Chinese Journal of Pharmaceutical Analysis,2012,32(11):2064-2067.
[10] Song X M,Yang X J,Wang W,et al. HPLC Fingerprint and Chemical Pattern Recognition of Rhizoma Panacis Majoris[J]. Chinese Journal of Experimental Traditional Medical Formulae,2011,17(11):59-62.

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备注/Memo

备注/Memo:
基金项目: 北京市科技新星计划(xx2015A048)
作者简介: 滕会会(1988- ),女,2013级在读硕士研究生。研究方向:中药中药新剂型与新技术研究。E-mail:h15810377850@163.com
通讯作者: 杜守颖(1960- ),女,博士,教授,博士生导师。研究方向:中药新剂型与制剂关键技术。E-mail:dushouying@263.net
更新日期/Last Update: 2016-11-06