|本期目录/Table of Contents|

[1]姜颖娟 蔡玲玲 汤化琪 李元文 孙毅坤.不同药物配伍与不同基质对甘石青黛膏经皮吸收的影响[J].环球中医药,2017,10(05):532-535.[doi:10.3969/j.issn.1674-1749.2017.05.005]
　JIANG Yingjuan,CAI Lingling,TANG Huaqi,et al.Effect of different compatibility and different matrices on transdermal absorption of Ganshi Qingdai ointment[J].,2017,10(05):532-535.[doi:10.3969/j.issn.1674-1749.2017.05.005]
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不同药物配伍与不同基质对甘石青黛膏经皮吸收的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年05期
页码:
532-535
栏目:
论著
出版日期:
2017-05-06

文章信息/Info

Title:
Effect of different compatibility and different matrices on transdermal absorption of Ganshi Qingdai ointment
作者:
姜颖娟 蔡玲玲 汤化琪 李元文 孙毅坤
100078 北京中医药大学东方医院皮肤科(姜颖娟、蔡玲玲、李元文); 北京中医药大学中药学院[汤化琪(硕士研究生)、孙毅坤]
Author(s):
JIANG Yingjuan; CAI Lingling; TANG Huaqi; et al.
Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China
关键词:
甘石青黛膏;  靛蓝;  靛玉红;  透皮吸收
Keywords:
Ganshi Qingdai ointment;  Indigo;  Indirubin;  Percutaneous absorption.
分类号:
R284
DOI:
10.3969/j.issn.1674-1749.2017.05.005
文献标志码:
A
摘要:
目的 建立甘石青黛膏透皮实验中靛蓝及靛玉红的测定方法,考察甘石青黛膏全方与拆方,以及不同基质下靛蓝及靛玉红的体外经皮渗透行为,探讨不同药物配伍与不同基质对其透皮效果的影响。方法 采用Franz扩散池,以离体鼠皮为屏障,用高效液相色谱法测定接受液中靛蓝及靛玉红的量; 考察全方与拆方、凡士林基质以及橄榄油基质下靛蓝及靛玉红的透皮特性。结果 全方组的透皮速率和累计渗透量均大于拆方组,且差异有统计学意义(P＜0.05); 橄榄油基质对软膏中靛蓝的渗透效果较凡士林基质明显,而二者对靛玉红的影响没用显著性差异。结论 不同药物配伍与不同基质对甘石青黛膏中靛蓝及靛玉红的透皮吸收均有影响。
Abstract:
Objective To establish the determination method of indigo and indirubin in transdermal experiment in vitro,study the permeation behavior of indigo and indirubin in whole and disassembled prescription and in different matrices. To investigate the effects of different drugs and different matrices on the transdermal effect. Methods The permeation was studied on rat skin with Franz diffusing cell, the content of indigo and indirubin was detected by HPLC. The transdermal permeability of indigo and indirutin in whole and disassembled prescription and in different matrices were evaluated. Results Skin penetration rate and cumulative infiltration in whole prescription were higher than those in disassembled prescription; The penetration of indigo was better in olive oil than in petroleum jelly, while there was no significant difference of indirubin. Conclusion Different compatibility and different matrices of Ganshi Qingdai ointment has effect on the percutaneous absorption of indigo and indirubin.

参考文献/References:

[1] 马莉,孙琴,李友,等.HPLC法测定板蓝根药材及制剂中靛蓝和靛玉红含量[J].药物分析杂志,2010,30(9):1642-1645.
[2] 王金鹏,孙翠萍,林海霞,等.HPLC测定复方南板蓝根颗粒中靛蓝和靛玉红的含量[J].中国实验方剂学杂志,2012,18(21):128-130.
[3] 兰颐,王琼,安静,等.不同接受液对药物体外透皮试验的影响[J].中国实验方剂学杂志,2013,19(13):7-10.

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备注/Memo

备注/Memo:
基金项目: 北京市科委“十病十药”专项(Z131100002513013)
作者简介: 姜颖娟(1981- ),女,博士,主治医师。研究方向:中西医结合治疗皮肤病性病。E-mail:jiangyingjuan@163.com
通信作者: 李元文(1962- ),本科,主任医师,博士生导师。研究方向:中西医结合治疗皮肤病性病。E-mail:yuan-wen@sohu.com
更新日期/Last Update: 2017-05-06