|本期目录/Table of Contents|

[1]孟丹 朱莹杰.“热毒冶与消化道肿瘤的研究进展[J].环球中医药,2017,10(06):668-672.[doi:10.3969/j.issn.1674-1749.2017.05.039]
 MENG Dan,ZHU Yingjie..Research progress of “heat toxin” and the gastrointestinal cancers[J].,2017,10(06):668-672.[doi:10.3969/j.issn.1674-1749.2017.05.039]
点击复制

“热毒冶与消化道肿瘤的研究进展()
     
分享到:

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年06期
页码:
668-672
栏目:
综述
出版日期:
2017-06-06

文章信息/Info

Title:
Research progress of “heat toxin” and the gastrointestinal cancers
作者:
孟丹 朱莹杰
200032 上海中医药大学附属龙华医院肿瘤一科[孟丹(硕士研究生)、朱莹杰]
Author(s):
MENG DanZHU Yingjie.
LONGHUA Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032,China
关键词:
清热解毒 消化道肿瘤 中医药
Keywords:
Heat-clearing and toxin-resolving Gastrointestinal cancer Traditional Chinese medicine
分类号:
R735
DOI:
10.3969/j.issn.1674-1749.2017.05.039
文献标志码:
A
摘要:
“热毒”是肿瘤的病因之一,所以热毒蕴结是消化道肿瘤发生、发展的重要病因之一,在消化道恶性肿瘤的预防和治疗中起着重要的作用。清热解毒类中药的功效各异,目前运用广泛的有单药、复方及静脉注射液。近年来的一系列实验研究提示清热解毒中药通过抑制细胞增殖、诱导凋亡、分化及逆转、调节机体免疫水平、调控细胞信号通路及传导、抑制血管生成和抗多药耐药等多种途径发挥抗肿瘤作用。本文仅从几个方面选取一些典型中药对消化道肿瘤的影响进行论述。
Abstract:
“Heat toxin” is one of the causes of cancer, accumulation and binding of heat-poison is an important pathogenesis of genesis and development in gastrointestinal cancer, it plays a important role in malignant tumor of digestive tract. The efficacy of heat-clearing and detoxicating drug is different. At present, the single drug, compound and intravenous injection is widely used. Experimental studies showed that heat-clearing and detoxicating drug has anti-tumor effect in inhibiting cell proliferation, inducing apoptosis, differentiation and reversion, regulating immune, regulating cell signaling pathways and conduction, inhibiting angiogenesis and anti-multidrug resistance. In this paper, the influence of some traditional Chinese medicine on digestive tract tumor is discussed from several aspects.

参考文献/References:

[1] 代敏,李霓,李倩,等.全球肿瘤预防控制概况[J].中国肿瘤,2011,20(1):21-25.
[2] 陈万青,张思维,曾红梅,等.中国2010年恶性肿瘤发病与死亡[J].中国肿瘤,2014,23(1):1-10.
[3] Ikeda F,Kiyohara Y.Helicobacter pylori infection and Hyperglycemia/Diabetes are associated with an increased risk of Gastric Cancer[J].Gan to Kagaku Ryoho, 2015,42(5):529-533.
[4] 崔娜娟,王洪琪.清热解毒中药在恶性肿瘤防治中的机理研究与应用概况[J].甘肃中医,2005,18(3):43-44.
[5] 孔祥勇.刘完素火热论学术思想探析吉林中医药[J],吉林中医药,2010,30(12):1015-1016
[6] Balkwill F, Mantovani A.Inflammation and cancer: back to Virchow?[J].Lancet,2001,357(9255):539-545.
[7] Coussens LM,Werb Z.Inflammation and cancer[J].Nature,2002,420(6917):860-867.
[8] Stix G.A malignant flame,Understanding chronic inflammation, which contributes to heart disease, Alzheimer's and a variety of other ailments, may be a key to unlocking the my steries of cancer[J].Sci Am, 2007; 297(1):60-67.
[9] Baron J A,Sandler R S,Bresalier R S,et al.A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas[J].Gastroenterology,2006,131(6):1674-1682.
[10] Bornschein J,Malfertheiner P.Gastric carcinogenesis[J].Langen becks Arch Surg,2011,396(6):729-742.
[11] 张友安,胡敏麟,马黔.幽门螺杆菌检测与中医辨证分型相关性观察[J].贵阳中医学院学报,1994,16(4):15-16.
[12] 沈诚,车国卫.炎症因子与肺癌研究进展[J].中华肿瘤防治杂志,2014,21(2):157-160.
[13] 赵浩如,李瑞,林以宁,等.白花蛇舌草不同提取工艺对抗肿瘤活性的影响[J].中国药科大学学报,2002,33(6):510 -513.
[14] 陈涛,崔帮平,黎家华,等.珠子参对小鼠H22肝癌抑制作用及机制[J].世界华人消化杂志,2007,15(24):2597-2601.
[15] 谭宝,石海莲,季光,等.蒲公英萜醇和乙醇蒲公英萜醇对胃癌细胞株AGS细胞周期和凋亡的影响[J].中西医结合学报,2011,9(6):638-642.
[16] 鲁平,张小峰,赵阳.红藤诱发胃腺癌细胞MCG-803凋亡的研究[J].医学信息旬刊,2011,24(7):219-220.
[17] 王琨,董惠芳,章晓鹰,等.夏枯草对SGC-7901细胞的影响[J].上海医学检验杂志,2000,15(5):305-306.
[18] 王涛,杨华山.菝葜乙酸乙酯提取物抗癌机制研究[J].肿瘤基础与临床,2007,20(2):129-131.
[19] 廖子君,张晓明,郭亚焕,等.菝葜皂苷元对胃癌BGC-823细胞增殖、凋亡影响的实验研究[J].现代肿瘤医学,2010,18(6):1085-1087.
[20] 王小平,白吉庆,叶峥嵘.藤梨根提取物对裸鼠移植人胃癌SGC-7901细胞瘤p53基因蛋白的影响[J].现代中医药,2012,32(1):56-57.
[21] 白吉庆,王小平,叶峥嵘.藤藤梨根提取物对人胃癌SGC-7901细胞瘤p53、Bcl-2基因表达的影响[J].陕西中医学报,2012,33(2):244-245.
[22] 白吉庆,王小平,叶峥嵘.藤梨根提取物对人胃癌SGC-7901细胞凋亡及Bcl-2的影响[J].陕西中医学院学报,2012,35(1):59-61.
[23] 阮小丽,施大文.山慈菇的抗肿瘤及抑菌作用[J].中药材,2009,32(12):1886-1888.
[24] 王洪琦,崔娜娟,胡玲,等.清热解毒和补益中药对小鼠腹水肝癌H22细胞的作用及免疫学机制比较[J].广州中医药大学学报,2006,23(2):156-159.
[25] 徐珊,徐昌芬.肿瘤多药耐药性发生机制及中药逆转作用的研究进展[J].中国肿瘤生物治疗杂志,2006,13(6):404-410.
[26] 林久茂,詹友知,魏丽慧,等.白花蛇舌草提取物逆转结肠癌细胞5-Fu耐药的作用[J].福建中医药,2013,44(1):53-55.
[27] 韩英,布利民,纪欣,等.穿琥宁对大肠癌HCT-8/5-FU耐药细胞株逆转作用的研究[J].中国新药杂志,2004,13(5):404-407.
[28] Folkman J.Anigogenesis in cancer,vaseular,rheumatoid and other disease[J].Nat Med,1995,1(1):27-31.
[29] GP Chrousos.Seminars in Medicine of the Beth Israel Hospital, Boston Clinical applications of research on angiogenesis[J].N Engl J Med,1995,333:1757-1763.
[30] Vlahakis NE,Young BA,Atakilit A,et al.Integrin alpha9beta1 directly binds to vascular endothelial growth factor(VEGF)-A and contributes to VEGFA-induced angiogenesis[J].Journal of Biological Chemistry,2007,282(20):15187-15196.
[31] 胡静,钱晓萍,刘宝瑞,等.重楼醇提物体外抑制血管生成作用研究[J].现代肿瘤医学,2008,16(8):1273-1278.
[32] 季宇彬,高世勇,孔琪,等.海嘧啶对肿瘤细胞内[Ca2+]i的影响[J].中草药,2001,32(12):1093–1097
[33] 季宇彬,高世勇.海嘧啶体内外抗肿瘤作用研究[J].中国药学杂志2005,40(23):1788-1793.
[34] 沈克平,刘威,胡兵,等.四藤方对人胃癌SGC-7901细胞黏附和侵袭的影响[J].世界华人消化杂志,2010,18(34):3616-3620.
[35] 沈克平,胡兵,刘威.四藤方对Bel-7402细胞增殖和凋亡作用研究[J].中国实验方剂学杂志,2011,17(3):120-123.
[36] 刘琳,陈宝安,秦叔逵,等.三氧化二砷联合华蟾素抗裸鼠人肝癌移植瘤血管新生的作用[J].中国中西医结合杂志,2011,31(1):67-72.
[37] 莫隽全,谭卫民,庄思敏,等.岩舒对人大肠癌细胞株HCT8/VCR多药耐药的逆转作用及P糖蛋白表达的影响[J].现代医院,2012,12(10):15-18.
[38] 陈闯,张作军,陈蔚,等.复方苦参碱注射液联合健脾理气方治疗晚期原发性肝癌33例[J].中国中西医结合消化杂志,2006,14(1):51-52.

相似文献/References:

备注/Memo

备注/Memo:
作者简介: 孟丹(1990- ),女,2014级在读硕士研究生。研究方向:中西医结合防治消化道恶性肿瘤。E-mail:mengdan703@163.com
通信作者: 朱莹杰(1970- ),女,硕士,硕士生导师。研究方向:中西医结合防治消化道恶性肿瘤。E-mail:yjzzz1998@126.com
更新日期/Last Update: 2017-06-06