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[1]衡衍 李德魁 马淑然 蔡月超 许筱颖.极端气候变化对金黄地鼠血清褪黑素、IL-1、IL-6、CD3+、CD4+、CD8+的影响[J].环球中医药,2017,10(08):817-820.[doi:10.3969/j.issn.1674-1749.2017.08.004]
　HENG Yan,LI Dekui,MA Shuran,et al.Influence of extreme climate variations on serum MT、IL-1、IL-6、CD3+、CD4+、CD8+ of golden hamster[J].,2017,10(08):817-820.[doi:10.3969/j.issn.1674-1749.2017.08.004]
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极端气候变化对金黄地鼠血清褪黑素、IL-1、IL-6、CD3+、CD4+、CD8+的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年08期
页码:
817-820
栏目:
论著
出版日期:
2017-08-06

文章信息/Info

Title:
Influence of extreme climate variations on serum MT、IL-1、IL-6、CD3+、CD4+、CD8+ of golden hamster
作者:
衡衍 李德魁 马淑然 蔡月超 许筱颖
100029 北京中医药大学基础医学院[衡衍(硕士研究生)、李德魁、马淑然、蔡月超、许筱颖]; 重庆邮电大学医院中医骨伤科(衡衍)
Author(s):
HENG Yan;  LI Dekui;  MA Shuran;  et al.
School of Basic Medical Sciences,Beijing University of Chinese Medicine,Beijing 100029,China
关键词:
极端气候;  褪黑素;  免疫;  T细胞;  白介素
Keywords:
Extreme climate;  Melatonin;  Immunity;  T lymphocytes;  Interleukin
分类号:
R122.2
DOI:
10.3969/j.issn.1674-1749.2017.08.004
文献标志码:
A
摘要:
目的 基于“天人相应”理论,探讨极端气候对机体免疫功能的影响。 方法 将金黄地鼠按体重随机分为正常气候组、气温骤升组、气温骤降组、持续高温组、持续低温组、高温高湿组、常温高湿组共七组,借助人工气候模拟箱,进行极端气候模拟,干预结束后24小时、72小时取血,测定血清褪黑素(melatonine,MT)、白细胞介素1(interleukin,IL-1)、IL-6、免疫细胞表面抗原分子T细胞亚群(cluster of differentiation,CD3+、CD4+、CD8+)的含量。结果(1)高温高湿情况下金黄地鼠存活率为62.5%,其余情况下为100%。(2)极端气候结束24小时,与正常气候组相比,气温骤升情况下IL-1、IL-6、CD3+、CD4+有显著差异; 气温骤降情况下IL-1、CD8+有显著差异; 持续高温情况下IL-1、IL-6、CD8+有显著差异; 持续低温情况下MT、IL-1、IL-6、CD3+有显著差异; 高温高湿情况下IL-1有显著差异; 常温高湿情况下MT、IL-1、IL-6、CD3+、CD4+、CD8+均有显著差异。(3)极端气候结束72小时,与正常气候组相比,气温骤升情况下CD8+有显著差异; 气温骤降情况下IL-1、IL-6、CD3+有显著差异; 持续高温情况下IL-1、CD8+有显著差异; 持续低温情况下MT、IL-6、CD3+有显著差异; 常温高湿情况下MT、IL-1、IL-6、CD3+、CD4+、CD8+均有显著差异。结论(1)极端气候会对机体造成不利影响,尤以高温高湿为甚。(2)高湿度对免疫系统影响较为持久。(3)不同的极端气候对褪黑素及免疫功能的调节存在一定差异性和滞后性。
Abstract:
Objective To explore the influences of extreme climate variations on immunity functions of organism based on correspondence between nature and human theory. Methods The golden hamsters were randomly divided into ZC group, ZS group, ZJ group, CG group, CD group, GWGS group, GWGS group. Limatic simulation chambers was used to simulate extreme climates. Samples were collected after 24 hours and 72 hours respectively. MT、IL-1、IL-6、CD3+、CD4+、CD8+ of serum was detected.Results(1)Survival rate of golden hamster was 62.5% in hot and humid conditions, the remaining groups was 100%.(2)24 hours after the extreme climate, compared with ZC group, the content of IL-1, IL-6, CD3+, CD4+ in ZS group were significantly different; IL-1, CD8+ was significantly different in ZJ group; IL-1, IL-6, CD8+ was significantly different in CG group; MT, IL-1, L-6, CD3+ was significantly different in CD group; IL-1 was significantly different in GWGS group; MT, IL-1, IL-6, CD3+, CD4+, CD8+ was significantly different in CWGS group.(3)72 hours after the extreme climate, compared with ZC group, CD8+ was significantly different in ZS group; IL-1, IL-6, CD3+was significantly different in ZJ group; IL-1, CD8+ was significantly different in CG group; MT, IL-6, CD3+ was significantly different in CD group; MT, IL-1, IL-6, CD3+, CD4+, CD8+ was significantly different in CWGS group. Conclusion(1)Extreme climate can have adverse effects on the body, especially in high temperature and high humidity.(2)High humidity has a long-lasting effect on the immune system.(3)There are some differences and hysteresis quality in the regulation of melatonin and immune function in different extreme climates.

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金青年基金(30901887); 国家留学基金委员会资金; 北京中医药大学自主选题(2013-JYBZZ-JS-115)
作者简介: 衡衍(1983- ),2013级在读硕士研究生。研究方向:天人相应理论的文献、实验及临床研究; 中医骨伤的临床研究。E-mail:hengyan83@163.com
通信作者: 许筱颖(1974- ),女,博士,副教授,副主任医师,硕士生导师,北京市第四批老中医药专家学术继承人。研究方向:天人相应理论的文献、实验及临床研究。E-mail:xxy2006stone@163.com
更新日期/Last Update: 2017-08-06