|本期目录/Table of Contents|

[1]王秋虹 邱宗林 孙丰卉.基于数据挖掘的林兰教授治疗甲状腺功能亢进症的经验研究[J].环球中医药,2017,10(08):846-851.[doi:10.3969/j.issn.1674-1749.2017.08.011]
　WANG Qiuhong,QIU Zonglin,SUN Fenghui..Empirical study of professor Lin Lan in the treatment of hyperthyroidism based on data mining[J].,2017,10(08):846-851.[doi:10.3969/j.issn.1674-1749.2017.08.011]
点击复制

基于数据挖掘的林兰教授治疗甲状腺功能亢进症的经验研究()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年08期
页码:
846-851
栏目:
数据挖掘分析
出版日期:
2017-08-06

文章信息/Info

Title:
Empirical study of professor Lin Lan in the treatment of hyperthyroidism based on data mining
作者:
王秋虹 邱宗林 孙丰卉
100053 北京,中国中医科学院广安门医院内分泌科[王秋虹、邱宗林、孙丰卉(硕士研究生)]
Author(s):
WANG Qiuhong;  QIU Zonglin;  SUN Fenghui.
Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China
关键词:
数据挖掘;  林兰;  甲状腺功能亢进症;  临床经验
Keywords:
Data mining;  Lin Lan;  Hyperthyroidism;  Clinical experience
分类号:
R249
DOI:
10.3969/j.issn.1674-1749.2017.08.011
文献标志码:
A
摘要:
目的 基于林兰教授治疗甲状腺功能亢进症(以下简称甲亢)的临床资料,通过数据分析,总结其治疗甲亢的方药运用规律。 方法 筛选在广安门医院内分泌门诊确诊的160例甲亢患者的437诊次的病例录入Excel 2007表格。利用SPSS 19.0软件、weka 3.7数据挖掘软件、Liquorice数据挖掘软件,运用频数分析、关联规则、复杂网络等方法分析林兰教授处方用药规律,结合访谈交流,探析其诊治甲亢的思辨特色。 结果(1)频数在10次以上的药物共有64味,其中生龙骨、煅磁石、珍珠母、麦冬、酸枣仁、五味子、夏枯草、法半夏、山慈菇等是林老治疗甲亢的核心药物。林老治疗甲亢使用最多的是补虚药、安神药,其次为清热药、活血化瘀药、平肝息风药等。在补虚类药物使用上,以用补血药和补阴药为主,补气药和补阳药为次。(2)采用Liquorice数据挖掘软件对高频中药进行分析,结果显示生龙骨、煅磁石、夏枯草、枸杞子、钩藤、太子参、麦冬、白芍、五味子、生地黄、熟地黄、柏子仁、酸枣仁是最常见的方剂组合。(3)采用weka3.7数据挖掘软件,运用关联规则方法分析常用药对,并结合与林老交流总结出其临床常使用的药对。 结论 林兰教授认为甲亢以气、痰、瘀三者互相凝结,壅于颈前为基本病机。林兰教授治疗甲亢分气滞痰凝、阴虚阳亢、阴虚火旺、气阴两虚四型论治,重视化痰活血。林兰教授治疗甲亢的核心处方以滋阴潜阳、化痰散结、益气养阴功效为特点。
Abstract:
Objective Based on data analysis of the clinical data of Professor Lin in the treatment of hyperthyroidism to summarize the application rule of prescription. Methods 160 cases of patients with hyperthyroidism and totally 437 visits times in the endocrine clinic of Guang'anmen hospital were selected and the data was input EXCEL 2007 spreadsheet. The SPSS 19.0 software, weka 3.7 data mining software and Liquorice mining software were used. And frequency analysis, association rule and complex network were adopted to analyze the medication rule of prescription of Professor Lin Lan. Results(1)There were 64 drugs with more than 10 times of frequency. The Keel, Calcined magnet, Nacre, Ophiopogon japonicus, Semen Ziziphi Spinosae, Schisandra chinensis, Prunella vulgaris, Pinellia tuber, Mountain arrowhead and so on were the core drugs in the treatment of hyperthyroidism by Professor Lin Lan. The statistical results showed that the tonifying drugs and tranquilization medicine were the most widely used in treatment of hyperthyroidism by Professor Lin Lan, heat-clearing drugs, drugs for invigorating blood circulation and eliminating stasis, drugs for calming liver to stop endogenous wind in the second place. In the use of tonic drugs, the blood tonic and tonic Yin were the main ones, and the qi-tonifying drug and the Yang tonifying medicine were the second.(2)Liquorice mining software was used to analyse the high frequency herbal medicines, the results showed that Raw keel, Calcined magnet, Prunella vulgaris, Medlar, Uncaria,Radix Pseudostellariae, Ophiopogon root, White peony root, Schisandra, Prepared rhizome of rehmannia, Chinese arborvitae and Wild jujube benevolence was the most common combination in prescription.(3)Weka 3.7 data mining software and association rules was used to analyse the commom herbal pair and to summarize the most common herbal pair. Conclusion Professor Lin Lan believes that the basic pathogenesis of hyperthyroidism is coagulation of Qi, phlegm, blood stasis in front of the neck. Hyperthyroidism is divided into four types by Professor Lin Lan, there are qi stagnation and phlegm coagulation, yin deficiency and yang excess, fire excess from yin deficiency, deficiency of both qi and blood, and dissipating phlegm to activate blood is appreciated. Professor Lin Lan's core prescription for treating hyperthyroidism is characterized by Nourishing Yin, suppressing yang, resolving phlegm and masses, supplementing qi and nourishing yin.

参考文献/References:

[1] 中华医学会内分泌学分会《中国甲状腺疾病诊治指南编写组》.中国甲状腺疾病诊治指南——甲状腺功能亢进症[J].中华内科杂志,2007,46(10):876-882.
[2] 周琳,刘树春.关联规则在中医临床信息分析中的应用[J].2014,38(4):13-15.
[3] 周雪忠,刘保延,王映辉,等.复方药物配伍的复杂网络方法研究[J].中国中医药信息杂志,2008,15(11):98-100.
[4] 王映辉,周雪忠,张润顺,等.利用复杂网络与点式互信息法分析挖掘名老中医用药经验研究[J].中国数字医学,2011,4(24):76-80.
[5] 李鸣镝.林兰辨治甲状腺功能亢进症经验[J].中国中医基础医学杂志,2011,17(2):183-184.
[6] 郭小舟,魏军平,孟庆杰.林兰治疗甲状腺功能亢进症经验[J].上海中医药杂志,2010,44(11):9-10.
[7] 庞健丽,倪青,王洪武,等.林兰教授辨治甲亢性肝损害经验[J].四川中医,2009,27(9):6-7.
[8] 郑亚琳,黄达,林兰.林兰教授治疗甲状腺疾病经验介绍[J].新中医,2013,45(9):176.
[9] 刘丽娟.黄仰模教授中医治疗甲亢的经验[J].中国中医药现代远程教育,2008,6(10):1158-1159.
[10] 张杨.谢晶日中医药特色疗法治疗甲亢经验举隅[J].中医药信息,2012,29(1):70.
[11] 黄蔚,黄江荣.辨证治疗甲状腺机能亢进临床观察[J].湖北中医杂志,2011,33(10):39-40.
[12] 梁苹茂,张国霞.格雷夫斯病辨证治疗经验[J].中医杂志,2002,43(7):500-501.
[13] 林红.史奎钧治疗甲状腺功能亢进症经验[J].浙江中医杂志,2010,45(2):91.
[14] 刘娇萍,曹继刚,邹小娟,等.浅议象思维在甲状腺功能亢进症中医证候分型中的应用[J].湖北中医杂志,2012,34(9):27-28.
[15] 邝秀英.廖世煌辨治甲亢性甲状腺肿大的经验[J].江宁中医杂志,2001,28(7):398.
[16] Inga Spatari,刘公望.甲状腺功能亢进的中医辨证施治[J].天津中医药,2006,23(3):225-228.
[17] 德学慧,倪青,高齐健.甲状腺机能充进症证候量化诊断标准的探讨(一)[J].中国中医基础医学杂志,2008,14(8):621-622.
[18] 林兰,李鸣镝,刘喜明,等.中药甲亢宁治疗阴虚阳亢型甲状腺功能亢进症的临床研究[J].中国中西医结合杂志,1999,19(3):144-146.

相似文献/References:

[1]赵亚男 刘明.基于文献整理的臁疮四畔证型研究[J].环球中医药,2014,7(02):121.
[2]毛斌,吴宏赟,胡志强,等.关联规则在方剂数据挖掘中的应用述评[J].环球中医药,2013,6(10):791.
　MAO Bin,WU Hong yun,HU Zhi qiang..Commentary: Application of association rules in prescriptions data mining[J].,2013,6(08):791.
[3]刘本勇,姜楠,庞秀,等.应用数据挖掘探讨冯兴华教授治疗干燥综合征的用药规律[J].环球中医药,2013,6(11):831.
[4]龙晓华,王乐鹏,单体亮,等.基于数据挖掘的郑钦安用药规律研究[J].环球中医药,2015,8(05):540.[doi:10.3969/j.issn.16741749.2015.05.007]
　LONG Xiao hua,WANG Le peng,SHAN Ti liang,et al.Study on the medication regularities of ZHENG Qinan based on data mining[J].,2015,8(08):540.[doi:10.3969/j.issn.16741749.2015.05.007]

备注/Memo

备注/Memo:
基金项目: 中国中医科学院名医名家传承项目(CM2014GD1003)
作者简介: 王秋虹(1988- ),女,博士,住院医师,中国中西医结合学会内分泌专业委员会秘书。研究方向:中医药防治甲状腺疾病。E-mail:qiuhongfortune@126.com
更新日期/Last Update: 2017-08-06