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[1]尹逊路,朱立国,冯敏山,等.补肾活血方治疗骨性关节炎疗效的Meta分析[J].环球中医药,2017,10(10):1183-1188.[doi:10.3969/j.issn.1674-1749.2017.10.039]
　YIN Xunlu,ZHU Liguo,FENG Minshan,et al.Meta analysis of the effect Bushen Huoxue decoction in the treatment of osteoarthritis[J].,2017,10(10):1183-1188.[doi:10.3969/j.issn.1674-1749.2017.10.039]
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补肾活血方治疗骨性关节炎疗效的Meta分析()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年10期
页码:
1183-1188
栏目:
综述
出版日期:
2017-10-06

文章信息/Info

Title:
Meta analysis of the effect Bushen Huoxue decoction in the treatment of osteoarthritis
作者:
尹逊路; 朱立国; 冯敏山; 李玲慧; 李学朋; 于杰; 银河; 魏戌
100102 中国中医科学院望京医院脊柱二科[尹逊路(博士研究生)、朱立国、冯敏山、李玲慧、李学朋、于杰、银河、魏戌]
Author(s):
YIN Xunlu; ZHU Liguo; FENG Minshan; et al.
Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102,China
关键词:
补肾活血方;  骨性关节炎;  随机对照试验;  系统评价;  Meta分析
Keywords:
Bushen Huoxue decoction;  Osteoarthritis;  Meta analysis
分类号:
R285.6
DOI:
10.3969/j.issn.1674-1749.2017.10.039
文献标志码:
A
摘要:
目的 系统评价补肾活血方治疗骨性关节炎的有效性和安全性。方法 搜集与补肾活血方治疗骨性关节炎相关的随机对照研究,将纳入的研究按照Cochrane协作网推荐的方法评价其方法学质量,对纳入研究的测量指标通过Revman 5.3软件进行相关统计学分析。结果 经筛选后共纳入19项研究,共计2638例患者; Meta分析结果显示:单独服用或加服补肾活血方与单纯西医疗法相比其治疗总有效率[RR=1.14,95%CI(1.07,1.21)],疼痛减轻程度[RR=-0.76,95%CI(-0.93,-0.6)],药物不良反应发生率[RR=0.26,95%CI (0.11,0.63)],差异有统计学意义; 倒漏斗图显示不对称。结论 补肾活血方治疗骨性关节炎具有一定的疗效和优势。但本系统评价存在样本量小、低质量纳入研究较多以及各研究间异质性较大等不足,因此今后有必要开展大样本、高质量的随机对照试验进行验证。
Abstract:
Objective To systematically evaluate the efficacy and safety of Bushen Huoxue decoction in the treatment of osteoarthritis. Methods Randomized controlled trials of Bushen Huoxue decoction in the treatment of osteoarthritis were collected. The methodological quality of trials was assessed according to the criteria recommended by Cochrane Handbook.The heterogeneity test, meta-analyses, sensitivity analyses and funnel plot analyses was analyzed by the RevMan Manager 5.3. Results Nineteen qualified trials were included and 2638 patients were collected. Meta-analysis showed total effective rate of [RR=1.14, 95%CI(1.07, 1.21)], the pain relief degree of [RR=-0.76, 95%CI(-0.93, -0.6)], the incidence of adverse reaction of [RR=0.26, 95%CI (0.11, 0.63)in alone or with Bushen Huoxue decoctionthe therapy was better than western medicine therapy, the difference was statistically significant. The funnel plot indicated that the model was asymmetric. Conclusion Bushen Huoxue decoction has certain curative effects and advantages in the treatment of osteoarthritis. However, there are some deficiencies in this system, such as small sample size, low quality and heterogeneity among different studies was lager. Therefore, it is necessary to carry out a large sample and high-quality randomized controlled trial to verify it.

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相似文献/References:

[1]徐涛,鲍自立,朱金华,等.补肾活血方对踝关节骨折切开复位内固定术后血清钙、碱性磷酸酶的影响[J].环球中医药,2016,9(09):1125.[doi:10.3969/j.issn.1674-1749.2016.09.031]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81674005); 北京市自然科学基金(7164313); 中国博士后科学基金(2016M591364); 国家中医药管理局科研专项课题(JDZX2015274)
作者简介: 尹逊路(1988- ),2016级在读博士研究生,住院医师。研究方向:脊柱及相关疾病研究。E-mail:yin_xun_lu@163.com
通信作者:朱立国(1961- ),博士,主任医师。研究方向:脊柱及相关疾病研究。E-mail:zhlg95@aliyun.com
更新日期/Last Update: 2017-10-06