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[1]张嘉琰,张立平,陈丽如,等.柴芪汤对代谢综合征性肾损害大鼠的干预作用研究[J].环球中医药,2017,10(11):1202-1206.[doi:10.3969/j.issn.1674-1749.2017.11.004]
　ZHANG Jiayan,ZHANG Liping,CHEN Liru,et al.Effects of Chaiqi decoction on metabolic syndrome of rats with renal damage[J].,2017,10(11):1202-1206.[doi:10.3969/j.issn.1674-1749.2017.11.004]
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柴芪汤对代谢综合征性肾损害大鼠的干预作用研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年11期
页码:
1202-1206
栏目:
论著
出版日期:
2017-11-06

文章信息/Info

Title:
Effects of Chaiqi decoction on metabolic syndrome of rats with renal damage
作者:
张嘉琰; 张立平; 陈丽如; 彭龙
100078 北京中医药大学东方医院脾胃肝胆科 [张嘉琰(博士研究生)、陈丽如、彭龙]; 北京中医药大学研究生院(张立平)
Author(s):
ZHANG Jiayan; ZHANG Liping; CHEN Liru; et al.
Departrent of spleen and stomach, Dongfang Hospital Affiliated to Beijing University of Traditional Chinese Medicine,Beijing 100078,China
关键词:
代谢综合征;  肾损害;  健脾疏肝;  柴芪汤
Keywords:
Metabolic syndrome;  Kidney damage;  Invigorating spleen and soothing liver;  Chaiqi decoction
分类号:
R285.5
DOI:
10.3969/j.issn.1674-1749.2017.11.004
文献标志码:
A
摘要:
目的 观察柴芪汤对饮食诱导的代谢综合征大鼠糖脂代谢紊乱及代谢综合征性肾损害的干预效果。方法 将40只SPF级雄性SD大鼠随机分成正常组、模型组、中药组、西药组,除正常组外其余各组用高盐高脂高糖饲料喂养。中药组从造模第一天开始给予柴芪汤[5.71 g/(kg·d)]灌胃,西药组从造模第一天开始给予盐酸吡格列酮混悬液[2.7 mg/(kg·d)]灌胃,正常组和模型组给予生理盐水灌胃做对照,共16周。第16周末检测大鼠血清血糖、血脂、胰岛素,评价胰岛素抵抗。同时检测血清肌酐、尿素氮,比色法检测24小时尿蛋白定量,评价肾损害程度。并测量大鼠血压,HE染色观察肾脏病理改变。结果 模型组大鼠血糖、胰岛素、胰岛素抵抗指数、血脂、肌酐、尿素氮、尿酸、24小时尿蛋白定量、血压水平均明显高于正常组(P<0.05)。中药柴芪汤,西药盐酸吡格列酮干预组各项指标均低于模型组,仍高于正常组,差异有统计学意义(P<0.05)。结论 柴芪汤可改善代谢综合征大鼠的糖脂代谢紊乱,减轻代谢综合征性肾损害的程度,延缓其进展。
Abstract:
Objective To observe the intervention effects of Chaiqi decoction on glucose and lipid metabolism and renal injury induced by metabolic syndrome in metabolic syndrome rats induced by diet. Methods The forty SPF male SD rats were randomly divided into normal group, model group, traditional Chinese medicine group, western medicine group. The rat model was established by feeding high fat, high sugar and high salt diet. The Chinese medicine group was given Chaiqi decoction [5.71 g/(kg·d)] from the beginning of modeling, and western medicine group was given Pioglitazone hydrochloride suspension from the beginning of modeling. The blood glucose, blood lipids and insulin were detected at 16th week, the insulin resistance was evaluated. At the same time, the serum creatinine, urea nitrogen was detected, 24h urinary protein quantification was detected by colorimetric assay to dvaluate the extent of damage of renal impairment. Blood pressure was measured and HE staining was used to observe the pathological changes of the kidneys. Results Compared with normal group, the blood glucose, blood lipids, insulin, insulin resistance index, serum creatinine, urea nitrogen, 24h urinary protein quantification were significantly increased in model group(P<0.05). All the index of the Chinese medicine Chaiqi decoction, western medicine group were lower than those of model group, the difference was statistically significant(P<0.05), but still higher than the normal group. Conclusion Chaiqi decoction can improve metabolic syndrome in rats with glucose and lipid metabolism disorders, and reduce the extent of damage of renal impairment induced by metabolic syndrome, delay the development.

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金(81273695)
作者简介: 张嘉琰(1989- ),女,2015级在读博士研究生。研究方向: 中医内科学脾胃肝胆。 E-mail:463163698@qq.com
通信作者: 张立平(1963- ),女,博士,教授,主任医师,博士生导师。研究方向: 中医内科学脾胃肝胆。 E-mail: lpzhang2005@126.com
更新日期/Last Update: 2017-11-06