|本期目录/Table of Contents|

[1]李维熙,刘冬丽,苏薇薇,等.酸角壳提取物对蔗糖负荷大鼠血糖及α-葡萄糖苷酶和α-淀粉酶的影响[J].环球中医药,2017,10(11):1218-1223.[doi:10.3969/j.issn.1674-1749.2017.11.007]
　LI Weixi,LIU Dongli,SU Weiwei,et al.Effects of tamarind shell on sucrose tolerance and the activity of α-glucosidase and α-amylase in sucrose-loaded rats[J].,2017,10(11):1218-1223.[doi:10.3969/j.issn.1674-1749.2017.11.007]
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酸角壳提取物对蔗糖负荷大鼠血糖及α-葡萄糖苷酶和α-淀粉酶的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年11期
页码:
1218-1223
栏目:
论著
出版日期:
2017-11-06

文章信息/Info

Title:
Effects of tamarind shell on sucrose tolerance and the activity of α-glucosidase and α-amylase in sucrose-loaded rats
作者:
李维熙; 刘冬丽; 苏薇薇; 高永坚
510275 广州,中山大学生命科学学院(李维熙、苏薇薇); 国药集团广东环球制药有限公司(李维熙、高永坚); 云南中医学院中药学院(李维熙、刘冬丽)
Author(s):
LI Weixi;  LIU Dongli;  SU Weiwei; et al.
School of Life Sciences,Sun Yat-sen University, Guangzhou 510275, China
关键词:
酸角壳提取物;  糖负荷;  α-葡萄糖苷酶;  α-淀粉酶
Keywords:
Tamarind shell extract;  Glycemic load;  α-glucosidase;  α-amylase
分类号:
R285.5
DOI:
10.3969/j.issn.1674-1749.2017.11.007
文献标志码:
A
摘要:
目的 研究酸角壳提取物对蔗糖负荷大鼠糖吸收的抑制作用。方法 采用蔗糖负荷大鼠模型观察酸角壳提取物对蔗糖负荷后不同时间点血糖的影响; 采用酶标法测定酸角壳提取物对正常大鼠肠黏膜和内容物中α-葡萄糖苷酶和α-淀粉酶活性的影响,评价酸角壳提取物对肠道α-葡萄糖苷酶和α-淀粉酶活性的影响。结果 各剂量酸角壳提取物能显著降低蔗糖负荷后15分钟大鼠的血糖水平(P<0.01)。酸角壳提取物能明显抑制小肠上段和中段α-葡萄糖苷酶以及小肠中段α-淀粉酶的活性,在给药30分钟到1小时的抑制作用最为显著。结论 酸角壳提取物能够显著降低蔗糖负荷后大鼠的血糖水平,其作用可能与抑制肠道α-葡萄糖苷酶和α-淀粉酶活性有关。
Abstract:
Objective To study the inhibitory effects of tamarind shell extract on intestinal absorption of sucrose. Methods The sucrose load model of rats were used and blood glucose levels were analyzed chronologically to evaluate the effect of tamarind extract. In vivo experiments were also performed to study the inhibitory effects of tamarind shell extract on the activities of α-glucosidase and α-amylase in the small intestinal mucosa and contents of rats. Results Tamarind shell extract of all doses had significant effects on the blood glucose levels after 15 min and 30 min of surcrose administration(P<0.01). Tamarind shell extract also significantly inhibited the activities of α-glucosidase and α-amylase in the small intestinal mucosa and contents. Conculusion Tamarind shell extract could effectively reduce the blood glucose level in sucrose-loaded rats. The mechanism might be related to its inhibitory effects on the activities of α-glucosidase and α-amylase.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介: 李维熙(1982- ),女,博士,讲师。研究方向:天然产物活性。E-mail:Weixi_li@qq.com
通信作者: 高永坚(1968- ),本科,高级工程师。研究方向:天然产物活性。E-mail:23734909@qq.com
更新日期/Last Update: 2017-11-06