|本期目录/Table of Contents|

[1]邹大威,高彦彬,李娇阳,等.通心络对2型糖尿病肾病大鼠纤溶调节因子PAI-1表达的影响[J].环球中医药,2017,10(12):1434-1437.[doi:10.3969/j.issn.1674-1749.2017.12.004]
　ZOU Dawei,GAO Yanbin,LI Jiaoyang,et al.Effects of Tongxinluo on PAI-1 level in rats with type 2 diabetic nephropathy[J].,2017,10(12):1434-1437.[doi:10.3969/j.issn.1674-1749.2017.12.004]
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通心络对2型糖尿病肾病大鼠纤溶调节因子PAI-1表达的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年12期
页码:
1434-1437
栏目:
论著
出版日期:
2017-12-06

文章信息/Info

Title:
Effects of Tongxinluo on PAI-1 level in rats with type 2 diabetic nephropathy
作者:
邹大威; 高彦彬; 李娇阳; 周盛楠; 张娜; 吴晓明; 田年秀; 王晓磊; 朱智耀
100069 北京,首都医科大学中医药学院 中医络病研究北京市重点实验室[邹大威、高彦彬、李娇阳(硕士研究生)、周盛楠(硕士研究生)、张娜(博士研究生)、吴晓明(博士研究生)、田年秀(博士研究生)、王晓磊(硕士研究生)、朱智耀]
Author(s):
ZOU Dawei;  GAO Yanbin; LI Jiaoyang; et al.
Capital Medical University, School of Traditional Chinese Medicine & Beijing Key Laboratory of TCM Collateral Disease Theory Research,Beijing 100069,China
关键词:
糖尿病肾病;  通心络;  纤溶;  组织型纤溶酶原激活剂;  纤溶酶原激活物抑制物-1
Keywords:
Diabetic nephropathy;  Tongxinluo;  Hemorheology;  Tissue plasminogenemia activator;  Plasminogen activator inhibitor-1
分类号:
R285.5
DOI:
10.3969/j.issn.1674-1749.2017.12.004
文献标志码:
A
摘要:
目的 观察通心络对2型糖尿病肾病大鼠血流变、纤溶调节因子表达的影响。 方法 采用高脂饲料联合小剂量链脲佐菌素建立2型DN大鼠模型,随机分为模型组和通心络组各10只,设立10只正常SD大鼠为空白组; 予通心络干预16周后,大鼠腹主动脉取血,测定空腹血糖(fasting blood glucose, FBG)、血清尿素氮(urea nitrogen, BUN)、血清肌酐(serum creatinine, Scr)、全血黏度(高切、低切)、血浆黏度、血小板聚集率、血浆纤维蛋白原、组织型纤溶酶原激活剂(tissue plasminogenemia activator,tPA)及纤溶酶原激活剂抑制剂-1(plasminogen activator inhibitor-1,PAI-1)。 结果 与空白组比较,模型组大鼠FBG、BUN、Scr均明显升高(P<0.05); 全血黏度(高切、低切)、血浆黏度、血小板聚集率、血浆纤维蛋白原及PAI-1明显升高,t-PA明显降低。与模型组比较,通心络组BUN、Scr均明显降低(P<0.05),高、低切变率下的全血黏度、血浆黏度、血浆纤维蛋白原含量、血小板聚集率及PAI-1水平明显降低(P<0.05),但对FBG、tPA水平没有明显的影响。 结论 通心络可保护2型糖尿病肾病大鼠肾功能、减轻肾脏病理损伤; 抗凝、降纤改善肾脏局部微循环灌注可能是其延缓DN进展的作用机制。
Abstract:
Objective To explore effects of Tongxinluo on hemorheology and PAI level in rats with type 2 diabetic nephropathy. Methods The rat model of type 2 diabetes mellitus was induced by injection of low-dose of streptozocin after having high-fat diet. Diabetic rats were randomly divided the model group(n=10)and the Tongxinluo group(n=10). Normal SD rats(n=10)were used as the control group. After intervention with Tongxinluo for 8 weeks, fasting blood glucose(FBG), serum creatinine(Scr), serum urea nitrogen(BUN), tissue plasminogen activator(t-PA), plasminogen activator inhibitor type-1(PAI-1)and hemorheology indexes were detected. Results Compared with control group, FBG, SCr, BUN, hemorheology indexes in the model group were significantly increased while the PAI-1 was decreased(P<0.05). Compared with model group, BUN and Scr were significantly decreased(P<0.05), hemorheology indexes and PAI-1 levels were significantly decreased(P<0.05), but the FBG and tPA level had no obvious influence.Conclusion TongXinLuo can protect renal function and alleviate renal pathological damage in type 2 diabetic nephropathy rats. Anticoagulation, defibringen and improving local microcirculation perfusion may be the mechanisms of delaying DN progression.

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备注/Memo

备注/Memo:
基金项目: 国家重点基础研究发展计划(973计划)(2012CB518602); 国家自然科学基金青年科学基金(81302951)
作者简介: 邹大威(1982- ),女,博士,讲师,主治医师。研究方向:中医药防治糖尿病研究。E-mail:sy_evergreen2012@163.com
通信作者: 高彦彬(1960- ),博士,教授,主任医师,博士生导师。研究方向:中医药防治糖尿病研究。E-mail:dfyynfm@163.com
更新日期/Last Update: 2017-11-06