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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第5卷

期数:

2012年02期

页码:

138-0

栏目:

综述

出版日期:

2012-02-06

文章信息/Info

Title:

Research progress of liver fire caused by emotional problems

作者:

王椿野; 郭蓉娟;

Author(s):

WANG Chun-ye; GUO Rong-juan.

Beijing University of Chinese Medicine, Beijing 100029,China

关键词:

肝郁化火证;  病因病机;  炎症;  神经体液调节;  人格

Keywords:

Liver stagnation fire;  Pathogenesis;  Inflammation;  Neurohumoral regulation;  Personality

分类号:

R22

DOI:

-

文献标志码:

A

摘要:

肝郁化火证是中医情志致病理论的重要病机之一,其在临床各科均十分常见,病因多由情志所伤,肝气郁结,致郁而化火。肝郁化火证的病机演变比较复杂,可伤阴,还可犯胃、刑金、扰肾、冲心、甚动风夹痰,形成更复杂的病机。肝郁化火证属于里实热证,治疗时除了清肝泻火,还要疏肝解郁。目前,对于肝郁化火证的基础研究,一般认为,肝郁化火时,机体处于炎症反应状态; 神经-体液代谢失调; 交感神经机能偏亢; 机体代谢旺盛,能量储备减少。肝郁化火证患者的易感因素可能与5-羟色胺转运体基因多态性、色氨酸羟化酶基因多态性关系较密切,心理学也证实了TABP之人肝火证的易感性。本文就目前肝郁化火证的中医病因病机,及其相关的现代本质研究进行总结讨论。

Abstract:

Syndrome of stagnation of liver fire is one of the important emotional pathogenic theories of Traditional Chinese Medicine pathogenesis, which are very common in clinic. It's caused emotional problems, liver Qi stagnation, which transforms into fire. Evolution of pathogenesis of liver stagnant fire is very complex, hyperactive Yang injuring essence of Yin, but also attacking the stomach,lung,kidney and heart, even forming phlegm and wind pathogenic factor, leading more complex pathogenesis. Syndrome of stagnation of liver-fire belongs to the syndrome of excessive heat in liver, treatment in addition to clearing liver and purging fire, course the liver and resolve depression. For now, basic research of syndrome of stagnation of liver fire mainly related to inflammation, neurohumoral regulation, gene and the personality, and so on. Generally, the body in the inflammatory state; neuro-humoral disorder, hyperfunction of sympathetic nerve function; massive metabolism, reduced energy reserves. Predisposing factor in patients with syndrome of stagnation of liver fire is related to 5-HTTLPR, TPH gene polymorphism and TABP. This article is about research into pathogenesis of traditional Chinese medicine and modern studies.

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备注/Memo

备注/Memo:

基金项目:高等学校博士学科点专项科研基金(20110013110008); 国家自然科学基金(81072717); 北京中医药大学创新团队项目(2011-CXTD-23)
作者单位：100029北京中医药大学[王椿野(博士研究生)]; 北京中医药大学东方医院脑病二科(郭蓉娟)
作者简介：王椿野(1981- ),2011级在读博士研究生。研究方向:中医药防治脑病基础及临床研究。E-mail:chaojichunye@hotmail.com
通讯作者：郭蓉娟(1964- ),女,博士,主任医师,博士生导师。研究方向:中医药防治脑病基础及临床研究。E-mail:dfgrj@yahoo.com.cn

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