[1]Arendrup.MC.Epidemiology of invasive candidiasis[J].Curr Opin Crit Care,2010,16(5):445452.
[2]Kothavade RJ,Oberai CM,Valand AG,et al.Disseminated cryptococcosis and fluconazole resistant oral candidiasis in a patient with acquired immunodeficiency syndrome (AIDS)[J].J Infect Dev Ctries,2010,4(10): 674678.
[3]Saunus JM,Kazoullis A,Farah CS.Cellular and molecular mechanisms of resistance to oral Candida albicans infections[J].Front Biosci,2008,13: 53455358.
[4]Wilson DT,Drew RH,Perfect JR.Antifungal therapy for invasive fungal diseases in allogeneic stem cell transplant recipients: an update[J].Mycopathologia,2009,168(6): 313327.
[5]Brito GN,Inocêncio AC,Querido SM.et al.In vitro antifungal susceptibility of Candida spp.oral isolates from HIVpositive patients and control individuals[J].Braz Oral Res,2011,25(1):2833.
[6]汪长中,程惠娟,官妍,等.黄连解毒汤对体外白念珠菌生物膜形成的影响[J].热带病与寄生虫学,2007,5(2): 8284.
[7]陶茂灿,夏修蛟,曹毅.黄连解毒汤体外抗真菌活性及其与西药的联合药敏试验研究[J].中华中医药学刊,2009,27(3): 585587.
[8]Holzknecht BJ,Thorup J,Arendrup MC,et al.Decreasing candidaemia rate in abdominal surgery patients after introduction of fluconazole prophylaxis[J].Clin Microbiol Infect,Clin Microbiol Infect,2011,17(9):13721380.
[9]MacCallum DM,Coste A,Ischer F,et al.Genetic Dissection of Azole Resistance Mechanisms in Candida albicans and Their Validation in a Mouse Model of Disseminated Infection[J].Antimicrob Agents Chemother,2010,54(4): 14761483.
[10]Sanglard D, Coste A, Ferrari S. Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation[J].FEMS Yeast Res,2009,9(7): 10291050.
[11]Coste A,Turner V,Ischer F,et al.A mutation in Tac1p,a transcription factor regulating CDR1 and CDR2,is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans[J].Genetics,2006,172(4): 21392156.
[12]Dunkel N,Blass J,Rogers PD,et al.Mutations in the multidrug resistance regulator MRR1,followed by loss of heterozygosity,are the main cause of MDR1 overexpression in fluconazoleresistant Candida albicans strains[J].Mol Microbiol,2008,69(4): 827840.
[13]Coste A,Crittin J,Bauser C,et al.Functional analysis of cis and transacting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system[J].Eukaryot Cell,2009,8(8): 12501267.
[14]Heilmann CJ,Schneider S,Barker KS,et al.An A643T Mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans[J].Antimicrob Agents Chemother,2010,54(1): 353359.
[15]Wirsching S,Michel S,Morschhuser J.Targeted gene disruption in Candida albicans wildtype strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates[J].Mol Microbiol,2000,36(4): 856865.
[16]Pinjon E,Moran GP,Jackson CJ,et al.Molecular mechanisms of itraconazole resistance in Candida dubliniensis[J].Antimicrob Agents Chemother,2003,47(8): 24242437.
[17]Morschhuser J.The genetic basis of fluconazole resistance development in Candida albicans[J].Biochemica et Biophysica Acta,2002,1587(23): 240248.
[18]Lamb DC,Kelly DE,White TC,et al.The R467K Amino Acid Substitution in Candida albicans Sterol 14αDemethylase Causes Drug Resistance through Reduced Affinity[J].Antimicrob Agents Chemother,2000,44(1): 6367.
[19]Marichal P, Vanden Bossche H, Odds FC. et al. Molecular biological characterization of an azoleresistant Candida glabrata isolate[J].Antimicrob Agents Chemother,1997,41(10): 22292237.
[20]Chau AS,Gurnani M,Hawkinson R,et al.Inactivation of sterol Δ5,6desaturase attenuates virulence in Candida albicans[J].Antimicrob Agents Chemother,2005,49(9): 36463651.
[21]Zhang H, Gao AL, Li FX, et al. Mechanism of action of tetrandrine, a natural inhibitor of Candida albicans drug efflux pumps[J].Yakugaku Zasshi,2009,129(5): 623633.
[22]Adams M, Mahringer A, Kunert O, et al. Cytotoxicity and pglycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa[J].Planta Med,2007,73(15): 15541557.
[23]Huang S,Cao YY,Dai BD,et al.In vitro synergism of fluconazole and baicalein against clinical isolates of Candida albicans resistant to fluconazole[J].Biol Pharm Bull,2008,31(12): 22342236.
[24]Cao YY,Dai BD,Wang Y,et al.In vitro activity of baicalein against Candida albicans biofilms[J].Int J Antimicrob Agents,2008,32(1): 7377.
[25]Liu X,Jiang JH,Shao JF,et al.Gene transcription profiling of Fusarium graminearum treated with an azole fungicide tebuconazole[J].Appl Microbiol Biotechnol,2010,85: 11051114.
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