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[1]李京,伍燕兵,曹志新,等.健脾益肺汤治疗肺脾气虚型慢性阻塞性肺疾病无创机械通气患者临床研究[J].环球中医药,2013,6(10):725-0.
　LI Jing,WU Yan bing,CAO Zhi xin,et al.Clinical research of Jianpi Yifei Decoction on treating COPD patients of lungspleen qi deficiency who need noninvasive mechanical ventilation[J].,2013,6(10):725-0.
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健脾益肺汤治疗肺脾气虚型慢性阻塞性肺疾病无创机械通气患者临床研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年10期
页码:
725-0
栏目:
论著
出版日期:
2013-10-06

文章信息/Info

Title:
Clinical research of Jianpi Yifei Decoction on treating COPD patients of lungspleen qi deficiency who need noninvasive mechanical ventilation
作者:
李京;伍燕兵;曹志新;曹锐;
Author(s):
LI Jing; WU Yanbing; CAO Zhixin; et al.
Beijing ChaoYang Hospital, Beijing 100020,China
关键词:
健脾益肺汤; 肺脾气虚型; 慢性阻塞性肺疾病; 无创机械通气; 呼吸肌疲劳
Keywords:
Jianpi Yifei (JPYF) Decoction; Qi deficiency of lung and spleen; Chronic obstructive pulmonary disease; Noninvasive mechanical ventilation; Respiratory muscle fatigue
分类号:
R563
DOI:
-
文献标志码:
A
摘要:
目的应用"健脾益肺汤",观察健脾益肺法改善肺脾气虚型慢性阻塞性肺疾病(COPD)无创机械通气患者呼吸肌疲劳的疗效。方法选取COPD急性加重期无创机械通气、中医辨证具有肺脾气虚证的临床特点的患者,采用随机、对照研究方法,随机分为对照组(标准治疗组)和治疗组(标准治疗+健脾益肺汤剂口服组)。从患者开始到结束无创机械通气期间,观察患者的中医症状、呼吸肌疲劳、血气分析等指标。结果治疗组患者中医症状改善有效率89.7%,对照组58.6%,治疗组显著优于对照组(P<0.01);两组均可升高动脉血氧分压、降低二氧化碳分压(P<0.05),疗后两组各项指标之间比较差异无统计学意义(P>0.05);两组治疗后较治疗前肺功能各项指标均有明显改善(P<0.05);治疗组最大吸气压、最大呼气压显著升高且优于对照组,同时可以改善患者用力呼气1秒容量和呼吸频率,与对照组比较差异均有统计学意义(P<0.05)。结论在常规无创通气治疗基础上,应用健脾益肺法,采用经验方"健脾益肺汤",能够进一步改善临床症状、缓解患者呼吸肌疲劳,改善呼吸衰竭。
Abstract:
ObjectiveTo observe the efficacy of adopting strengthening spleen and tonifying lung method by using JPYF decoction, to improve the muscle strength of COPD patientswho need noninvasive mechanical ventilation to release their respiratory muscle fatigue. MethodsSubjects for this study were acute exacerbation of COPD patients who need noninvasive mechanical ventilation therapy to release symptoms of respiratory failure, and all the patients have the traditional Chinese medicine clinical features of Qi deficiency of lung and spleen. A randomized, controlled study was performed. All the patients were randomly divided into control group (standard treatment group) and treatment group (standard treatment group+JPYF decoction orally taken group). Observation was started when patient began to receive noninvasive mechanical ventilation therapy, the patients clinical symptoms during the observation, indicators of respiratory muscle fatigue, blood gas analysis and other indicators were collected. ResultsThe clinical symptoms in treatment group were improved by 897%, and 586% of the control group, the treatment group was significantly better than the control group (P<001); two groups show increased PaO2, lower PaCO2(P<005) after treatment. After treatment, the indicators of the two groups had no significant difference (P>005); lung function were significantly improved after treatment (P<005); MIP、 MEP of treatment group were significantly increased than the control group, and compare to control group,FEV1% and RR can also be improved (P<005). ConclusionOn the basis of the conventional noninvasive ventilation, applying the method of strengthening spleen and tonifying lung, and using the experience prescription JPYF decoction can improve the clinical symptoms, relieve patients respiratory muscle fatigue and improve respiratory failure.

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备注/Memo

备注/Memo:
基金项目：北京市中医药科技项目（QN200901）
作者单位：100020 首都医科大学附属北京朝阳医院中医科（李京、曹锐），呼吸科（伍燕兵、曹志新）
作者简介：李京（1973- ），硕士，副主任医师，副教授。研究方向：呼吸病、脑病。Email：lj7357@vip.sina.com
通讯作者：曹锐（1963- ），主任医师。研究方向：呼吸病、心病、脑病。Email：caorui@vip.sina.com
更新日期/Last Update: 1900-01-01