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[1]霍青 于亚萍.中药治疗帕金森病临床疗效的系统评价[J].环球中医药,2014,7(01):29-0.
　HUO Qing,YU Ya ping..Systemically review of the clinical curative effect of Parkinsons disease treated with traditional Chinese medicine（TCM）[J].,2014,7(01):29-0.
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中药治疗帕金森病临床疗效的系统评价()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年01期
页码:
29-0
栏目:
论著
出版日期:
2014-01-06

文章信息/Info

Title:
Systemically review of the clinical curative effect of Parkinsons disease treated with traditional Chinese medicine（TCM）
作者:
霍青 于亚萍
Author(s):
HUO Qing; YU Yaping.
HUO Qing,YU Yaping. Affiliated hospital of Shandong University of Chinese Medicine, Jinan 250014, China
关键词:
帕金森病; 中药治疗; 临床疗效; 随机对照试验; 系统评价
Keywords:
Parkinsons disease; Treat with traditional Chinese medicine; Clinical curative effect; Randomized controlled trial; System evaluation
分类号:
R556
DOI:
-
文献标志码:
A
摘要:
目的系统评价中药治疗帕金森病的临床疗效及安全性。方法检索近二十余年来中药治疗帕金森病的随机、半随机对照试验文献，运用Jadad评分法进行质量评价，应用Cochrane协作网提供的软件Revman 422对相关数据进行异质性检验、Meta分析、漏斗图分析和敏感性分析。结果共纳入22个随机对照试验，包括患者1704例，其中试验组（中药或中药+左旋多巴制剂）877例，对照组（单用左旋多巴制剂）827例。Jadad评分显示2项研究得分大于3分，属高质量文献，其余均为低质量文献。Meta分析结果显示：(1)总有效率：两组帕金森病评定量表（UPDRS）减分率比较的合并相对危险度（95%可信区间）为125（113，140），差异有统计学意义，敏感性分析示统计结果稳定可靠。(2)UPDRS评分的变化：试验组的UPDRS总分、Ⅱ、Ⅲ相对于基线评分的变化均较对照组明显下降，两组的合并WMD（95%CI）分别为159（259，059），108（153，063），115（169，061），差异均有统计学意义，漏斗图分显示左右不对称，提示存在发表性偏倚可能性较大。(3)不良反应:试验组与对照组的胃肠道反应、便秘、失眠、精神症状、开关现象、低血压、剂末现象发生率的比较有显著性差异，流涎、头晕的发生率无统计学差异。结论现有的临床研究证据显示，与单纯用西药相比，中药能够减轻帕金森病的临床症状，改善病人的整体功能，提高其日常生活活动能力及运动功能，且安全性较高。中药配合西药可能优于单用西药，但因研究样本数量及质量的局限性，尚需更多高质量的大样本随机对照试验来进一步证实。
Abstract:
ObjectiveTo systemically review the clinical curative effect and safety for the treatment of Parkinsons disease treated with traditional Chinese medicine（TCM）.MethodsTo retrieve the randomized or half a randomized controlled trial documents of treating Parkinsons disease with TCM，which originate from the document of nearly 20 years. The quality evaluation of documents was measured using Jadad. The heterogeneity test, Meta  analysis of relevant data, funnel chart analysis and sensitivity analysis of documents were measured using Revman 4.2.2,which was provided by the Cochrane collaboration. ResultsThere were 22 randomized controlled trials, including the treatment group (treated with TCM or TCM + levodopa preparations) of 877 cases and in control group (treated with levodopa preparations) of 827 cases, totaling 1704 patients. 2 studies, scored more than 3 points measured by Jadad, were high quality documents, and the rest were low quality documents. The results, measured by Meta  analysis，showed (1)Total effective rate The merger of the two groups of UPDRS points rate RR (95% CI) was 1.25 (1.13, 1.40), the difference was statistically significant, the sensitivity analysis in the statistical result is stable and reliable. (2) UPDRS score changes Experimental UPDRS scores, Ⅱ, Ⅲ relative to the change of the baseline score significantly lower than control group, the combination of the two groups of WMD (95% CI) were respectively -1.59（-2.59, -0.59), -1.08(-1.53, -0.63), -1.15(-1.69, -0.61), the differences were statistically significant, funnel, asymmetry on figure points, note there published sex bias. (3)Adverse reactions Experimental group and control group in the gastrointestinal tract reaction, constipation, insomnia, mental symptoms, switch phenomenon, the incidence of hypotension, agent at the end of the phenomenon more significant difference, salivate, dizziness was no statistical difference. ConclusionThe existing clinical research evidence showed that using TCM can relieve the clinical symptoms of Parkinsons disease, improve the function of the patients, improve their ability of daily life activities and motor function, and high safety, compared with using western medicine alone. Combined TCM and western medicine to treat Parkinsons disease may be superior to western medicine alone, but because of the limitations of samplesquantity and quality, we still needs more high quality large sample randomized controlled trial to confirm.

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备注/Memo

备注/Memo:

作者单位：250014济南，山东中医药大学附属医院神经内科（霍青）；山东中医药大学第一临床医学院［于亚萍（硕士研究生） ］作者简介：霍青（1963-），女，博士，主任医师。研究方向：中医药治疗帕金森病的研究。Email:hq3701@163.com
更新日期/Last Update: 1900-01-01