[1]乌兰其其格 麻春杰 呼日乐巴根等.额尔敦—乌日勒对兔动脉粥样化易损斑块模型血清超敏C反应蛋白
及相关炎症因子的影响[J].环球中医药,2014,7(03):183-0.
Wulanqiqige,MA Chun jie,Hurilebagen,et al.Influences of serum hsCRP and relevant inflammatory factors on rabbit atherosclerotic vulnerable plaque model with Eerdunwurili[J].,2014,7(03):183-0.
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额尔敦—乌日勒对兔动脉粥样化易损斑块模型血清超敏C反应蛋白
及相关炎症因子的影响(
)
Wulanqiqige,MA Chun jie,Hurilebagen,et al.Influences of serum hsCRP and relevant inflammatory factors on rabbit atherosclerotic vulnerable plaque model with Eerdunwurili[J].,2014,7(03):183-0.
)《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]
- 卷:
- 第7卷
- 期数:
- 2014年03期
- 页码:
- 183-0
- 栏目:
- 论著
- 出版日期:
- 2014-03-06
文章信息/Info
- Title:
- Influences of serum hsCRP and relevant inflammatory factors on rabbit atherosclerotic vulnerable plaque model with Eerdunwurili
- 作者:
- 乌兰其其格 麻春杰 呼日乐巴根等
- Author(s):
- Wulanqiqige; MA Chunjie; Hurilebagen; et al.
- College of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
- Keywords:
- Eerdunwurili; Atherosclerosis; Highsensitivity Creactive protein; Inflammatory factors; Rabbits
- 分类号:
- R29
- DOI:
- -
- 文献标志码:
- A
- 摘要:
- 目的观察额尔敦—乌日勒对兔动脉粥样硬化易损斑块模型血清超敏C反应蛋白（high sensitivity Creactive protein，hsCRP）、单核细胞趋化蛋白1（monocyte chemoattractant protein 1，MCP1）、细胞间粘附因子（intercellular adhesion molecule，ICAM1）、血管粘附因子（vascular adhesion molecule1，VCAM1）的影响，以探讨额尔敦—乌日勒改善动脉粥样硬化易损斑块病变的可能机制。方法50只雄性新西兰大耳白兔随机分为4组，分别为正常组、模型组、额尔敦—乌日勒组及辛伐他汀组。通过高脂饲料、免疫损伤结合经股动脉球囊拉伤建立家兔动脉粥样硬化易损斑块模型，实验第8周开始给药至24周，取血检测炎症因子hsCRP、MCP1、ICAM1和VCAM1；取主动脉，光镜观察组织结构。结果额尔敦—乌日勒组主动脉病变程度相对较轻，纤维帽厚度与内中膜厚度比值高于模型组（P＜001），同时能明显降低动脉粥样硬化家兔血清hsCRP、ICAM1、VCAM1、MCP1含量（P＜001）。结论额尔敦—乌日勒可能通过抑制炎症反应，降低hsCRP、ICAM1、VCAM1、MCP1上升水平来发挥抗动脉粥样硬化（atherosclerosis,AS）的形成、发展和稳定易损斑块的作用。
- Abstract:
- ObjectiveTo observe the influences of serum high sensitivity Creactive protein (hsCRP), monocyte chemoattractant protein1 (MCP1), intercellular adhesion molecule (ICAM1), and vascular adhesion molecule1 (VCAM1) on rabbit model of atherosclerotic vulnerable plaque with Eerdunwurili and explore its possible mechanism. MethodsFifty New Zealand rabbits were randomly divided into 4 groups: the normal control group, the model group, the Eerdunwurili group and the smivastatin group.The model was established by high fatty diet feeding,combined with immune injury and femoral arterial balloon tearing. From the 8th week the medication was given and the levels of serum hsCRP，MCP1，ICAM1 and VCAM1 were measured at the 24th week of experiment. Tissue structure of aortic were observed under light microscope. ResultsAortic lesions is relatively milder in the Eerdunwurili group and the fibrous cap thickness and lntima media thickness ratios in the Eerdunwurili group were higher than those of model group; besides, the levels of serum hsCRP,、ICAM1,、VCAM1、and MCP1 were decreased significantly (P<001). ConclusionEerdunwurili could prevent AS formation and stabilize atherosclerosis vulnerable plaque. It acts by suppressing the inflammation reaction.
参考文献/References:
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备注/Memo
- 备注/Memo:
-
基金项目：国家自然科学基金（81160464）
作者单位：100029 北京中医药大学基础医学院［乌兰其其格（博士研究生）］；内蒙古医科大学蒙医药学院（乌兰其其格、呼日乐巴根、海英、布和朝鲁、白龙），中医学院（麻春杰、邸彦清）作者简介：乌兰其其格（1979- ）,女，2011级在读博士研究生，实验师。研究方向：蒙药药理研究。Email:mywulan2008@163.com通讯作者：麻春杰（1956- ），女，教授，博士生导师，主任医师。研究方向：中（蒙）医药防治心脑血管疾病的研究。Email:13514819729@163.com
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