|本期目录/Table of Contents|

[1]王旭昀 李海松 张宏等.右归胶囊对肾阳虚不育模型大鼠生殖功能影响的实验研究[J].环球中医药,2014,7(09):669-0.
　WANG Xu-yun,LI Hai-song,ZHANG Hong,et al.Influence of Yougui capsule on Kidney-Yang deficiency infertility rats' reproductive function[J].,2014,7(09):669-0.
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右归胶囊对肾阳虚不育模型大鼠生殖功能影响的实验研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年09期
页码:
669-0
栏目:
论著
出版日期:
2014-09-06

文章信息/Info

Title:
Influence of Yougui capsule on Kidney-Yang deficiency infertility rats' reproductive function
作者:
王旭昀 李海松 张宏等
Author(s):
WANG Xu-yun; LI Hai-song; ZHANG Hong; et al.
Deparment of TCM,Luhe Teaching hospital of Capital Medical University,Beijing,101149,China
关键词:
右归胶囊;  肾阳虚;  不育;  生殖功能
Keywords:
Yougui capsule;  Kidney-Yang deficiency;  Infertility;  Reproductive function
分类号:
R285.5
DOI:
-
文献标志码:
A
摘要:
目的 观察右归胶囊对腺嘌呤致肾阳虚不育模型大鼠生殖功能的影响。方法 以腺嘌呤灌胃SD大鼠,诱发肾阳虚不育模型,观察右归胶囊给药后实验动物睾丸、附睾、前列腺+精囊腺重量及睾丸曲细精管形态、曲细精管内各级生精细胞的数目和间质细胞的数目,各项指标皆与大鼠生殖功能有密切的关系。结果 右归组大鼠左侧睾丸、右侧睾丸,左侧附睾、右侧附睾,前列腺+精囊重量均低于正常组大鼠但高于模型组大鼠,差异有统计学意义。电镜下观察右归组大鼠睾丸病理切片,发现曲细精管萎缩较模型组明显减轻,各级生精细胞及间质细胞数量较模型组明显增多。结论 右归胶囊可提高腺嘌呤致肾阳虚不育模型大鼠生殖器官的重量,减轻腺嘌呤对睾丸曲细精管及各级生精细胞的损伤作用,对肾阳虚不育模型大鼠生殖功能具有保护作用。
Abstract:
Objective To discuss the influence of Yougui capsule on Kidney-Yang deficiency infertility rats' reproductive function. Methods The Kidney-Yang deficiency infertility model was established by feeding adenine. And the influence of Yougui capsule on the rats' reproductive function was observed through the weight of reproductive organs and testis Microstructure.Results In the Yougui capsule group, the weight of reproductive organs were higher than the the model group,but lower than the normal group. It could also improve the morphological changes of the tissue. In the Yougui capsule group, spermatogenic cells and mesenchymal cells are more than the model group.Its convoluted tubule morphology is also better than the the model group.Conclusion Yougui capsule can improve the model group rats' weight of testis,epididymis,prostate,seminal vesicles. In addition, Yougui capsule can cut down the damage of adenine on spermatogenic cells and mesenchymal. So,we think that it can improve the model group rats' reproductive function.

参考文献/References:

[1] 傅晓晴,林若勤,武一曼,等.腺嘌呤制作肾阳虚型慢性肾功能衰竭模型大鼠的生化研究[J].福建中医学院学报,2003,13(1):22-24.
[2]沈皓,蔡德培,陈伯英.补肾中药对下丘脑—垂体促性腺机能的影响[J].中西医结合学报,2004,2(1):53-57.
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[4]李春生,张国玺,石体仁,等.山茱萸水提取物对肾阳虚动物模型肝脏和睾丸影响的实验研究[J].中国中药杂志,2003,28(8):743-745.
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相似文献/References:

[1]郭灵龙,朱芸,万秀贤,等.郭立中教授从肾阳虚辨治失眠验案1则[J].环球中医药,2012,5(02):130.

备注/Memo

备注/Memo:
基金项目:北京市自然科学基金(7112074)
作者单位:101149 首都医科大学潞河教学医院中医科(王旭昀); 北京中医药大学东直门医院男科(李海松、党进); 北京中医药大学东方医院风湿科(张宏)
作者简介:王旭昀(1982- ),博士,主治医师。研究方向:中医药治疗外科、男科疾病。E-mail:xuyun1102@sina.com
更新日期/Last Update: 1900-01-01