|本期目录/Table of Contents|

[1]韩琳,秦建国,高誉珊,等.降压通络方对高血压肾损害大鼠肾脏血管紧张素II及肾功能的影响[J].环球中医药,2015,8(01):36-41.[doi:10.3969/j.issn.1674-1749.2015.01.010]
　HAN Lin,QIN Jian-guo,GAO Yu-shan,et al.Effects of Jiangya Tongluo Formula on the kidney and renal function in hypertension nephrosclerosis rats[J].,2015,8(01):36-41.[doi:10.3969/j.issn.1674-1749.2015.01.010]
点击复制

降压通络方对高血压肾损害大鼠肾脏血管紧张素II及肾功能的影响()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年01期
页码:
36-41
栏目:
论著
出版日期:
2015-01-06

文章信息/Info

Title:
Effects of Jiangya Tongluo Formula on the kidney and renal function in hypertension nephrosclerosis rats
作者:
韩琳; 秦建国; 高誉珊; 王媛媛; 张晓宇; 郭一; 宋林梅; 罗燕妮; 迟笑怡
100029 北京中医药大学基础医学院解剖教研室[韩琳、高誉珊、王媛媛、宋林梅(硕士研究生)]; 北京中医药大学东方医院肾内科[秦建国、张晓宇(硕士研究生)、郭一(硕士研究生)、罗燕妮(硕士研究生)、迟笑怡(硕士研究生)]
Author(s):
HAN Lin; QIN Jian-guo; GAO Yu-shan; et al.
School of Basic Medical Sciences, Beijing University of Chinese Medicine,Beijing,100029,China Corresponding author: QIN Jian-guo, E-mail:qintdtg@163.com
关键词:
降压通络方;  自发性高血压大鼠;  高血压病肾损害;  血管紧张素II
Keywords:
Jiangya Tongluo Formula;  Spontaneously hypertension rat;  Hypertension nephrosclerosis;  Angiotensin II
分类号:
R544.1
DOI:
10.3969/j.issn.1674-1749.2015.01.010
文献标志码:
A
摘要:
目的 观察降压通络方对自发性高血压肾损害大鼠肾脏血管紧张素II(angiotensin II, AngII)及肾功能的影响,探讨该方对高血压肾损害大鼠肾脏的保护机制。方法 采用16周龄自发性高血压大鼠(Spontaneously Hypertension Rat, SHR)为研究对象,将其随机分为模型组、缬沙坦组、降压通络方高、中、低剂量组、并设正常血压大鼠(Wistar Kyoto, WKY)为空白对照,分别灌胃给药。于给药后4周和8周分别测定大鼠尾动脉压力、血肌酐、尿素氮及肾脏AngII蛋白含量,并进行大鼠肾脏病理组织学检查。结果 给药4、8周后,与模型组比较,各治疗组大鼠血压、肾脏AngII含量明显降低(P<0.01,P<0.05),但给药4周各组之间比较无统计学意义,给药8周缬沙坦及降压通络方高、中剂量组均明显低于低剂量组(P<0.05); 缬沙坦及降压通络方能显著降低模型组大鼠血肌酐、尿素氮(P<0.01,P<0.05),改善肾小动脉及肾小球硬化,促进肾组织结构的恢复。结论 降压通络方能降低高血压肾损伤大鼠肾脏AngII含量,从而有效降低大鼠血压,改善肾脏病理损害,保护肾功能。
Abstract:
Objective o observe the effects of Jiangya Tongluo Formula on the content of AngII in kidney and the renal function in the model of hypertension nephrosclerosis.Methods Sixteen-week-old Spontaneously Hypertension rats were used as research subjects and then the rats were randomly divided into 5 groups: a model group, a Valsartan group, 3 Jiangya Tongluo groups and Wistar Kyoto rats were used as control group. All the rats were gavaged respectively. After 4 weeks and 8 weeks, the tail arterial pressure of the rats, Serum creatinine, Urea nitrogen and the dose of AngII in kidney were detected, At the same time, the histopathologic change in kidney tissue was also detected.Results After 4 weeks and 8 weeks gavage, compared to model group. The tail arterial pressure and the level of Ang II in kidney was decreased in Jiangya Tongluo groups and Valsartan group(P<0.01,P<0.05).But after 4 weeks gavage,there was no significant difference in therapeutic groups. After 8 weeks gavage, the date in Valsartan and Jiangya Tongluo high and medium dose groups were lower significantly than that of low dose group(P<0.05). Valsartan and Jiangyatongluo degraded the concentration of SCr, BUN in blood-serum significantly(P<0.01,P<0.05), improved the renal arteries and glomerular sclerosis, promoted the recovery of kidney tissue.Conclusion Jiangya Tongluo Formula could reduce the level of Ang II in kidney,decrease blood pressure, ameliorate renal pathologicallesion and protect renal function.

参考文献/References:

[1] Collins AJ,Foley RN,Chavers B,et al. United States Renal Data System 2011 Annual Data Report: Atlas of chronic kidney disease &end-stage renal disease in the United States[J]. AM J Kidney Dis,2012,59(1 Suppl 1): A7,e1- 420.
[2] Stel VS, van de Luijtgaarden MW, et al.The 2008 ERA-EDTA Registry Annual Report-a précis[J]. NDT Plus. Feb 2011, 4(1): 1-13.
[3] 中国高血压防治指南修订委员会.2004年中国高血压防治指南(实用本)[J].中华心血管病杂志,2004,32(12):1060-1064.
[4] 李树青,刘晓梅,王维忠.丹参对自发性高血压大鼠肾小动脉硬化治疗作用的实验研究[J].中华中医药学刊,2006,24(2):224-225.
[5] Zuccheli P, Zuccala A. Recent data on hypertention and progressive renal disease[J]. J Hum Hypertens,1996,10(10):679- 682.
[6] 蔡广研,寇佳,陈香美.高血压肾损害诊治新认识[J].中国实用内科杂志,2013,33(3):173-175.
[7] Fliser D. Perspectives in renal disease progression: the endothelium as a treatment target in chronic kidney disease[J]. J Nephrol,2010,23(4): 369-376.
[8] Kuo H T,Shin S J,Kuo M C,et al. Effects of specific endthelin-1 recepter antagonisis on proliferation and firbonectin production of glomerular mesangial cells stimulated with angiotensin Ⅱ[J].Kaohsiung J Med Sci,2006,22(8): 371-376.
[9] Shanley PF. The pathology of chronic renal ischemia[J]. Semin Nephrol, 1996, 16(1): 21-32.
[10] Wolf G, Neilson EG. Angiotensin II as a renal growth factor[J]. J Am Soc Nephrol, 1993; 3(9): 1531-1540.
[11] 杨赶梅,夏娣文,佘江健,等.芪蛭胶囊治疗高血压肾病肾功能不全20例临床观察[J].中国中医药科技,2002,9(4):232-233.
[12] 张琪,朱建军,袁杰.保元灌肠液治疗高血压患者早期肾脏损害60例.南京中医药大学学报(自然科学版)[J].2001,17(3):189-190.
[13] 秦建国,王亚红,曹征,等.降压通脉方对高血压病肾损害大鼠尿微量白蛋白、NAG酶的调节作用[C]//第二届(第21次)中华中医药学会肾病分会学术会议论文集.2008:568-569.
[14] 秦建国,王亚红,梁晋普,等.郭维琴治疗高血压病经验[J].中医杂志,2007,48(7):586-589.

相似文献/References:

[1]王永,曾凯,赵红佳,等.健心颗粒对慢性心衰大鼠心室肌toll样受体4、肿瘤坏死因子-α蛋白表达的影响[J].环球中医药,2015,8(04):411.[doi:10.3969/j.issn.1674-1749.2015.04.007]
　WANG Yong,ZENG Kai,ZHAO Hong-jia,et al.Effects of Jianxin Granule on the TLR4 and TNF-α of ventricular muscle in rats with chronic heart failure[J].,2015,8(01):411.[doi:10.3969/j.issn.1674-1749.2015.04.007]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(811734071),北京中医药大学自主选题项目(2332012JYBZZ-JS004); 北京市薪火传承郭士魁研究室项目(2011-SZ-A-27); 北京中医药管理局双百工程金章安教授传承项目 作者简介:韩琳(1970- ),女,博士,副教授。研究方向:肾脏疾病的临床与基础研究。E-mail:hanlinxf89@sohu.com 通讯作者: 秦建国(1971- ),博士,副主任医师,硕士研究生导师。研究方向:肾脏疾病的临床与基础研究。E-mail: qintdtg@16
更新日期/Last Update: 2015-01-05