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[1]王林,杨惠民,李贞玉,等.类风湿关节炎中医证型与血浆D-二聚体水平的临床观察[J].环球中医药,2015,8(02):134-137.[doi:10.3969/j.issn.1674-1749.2015.02.002]
　WANG Lin,YANG Hui-min,LI Zhen-yu,et al.Clinical observation of relationship between traditional Chinese medidcine syndromes of rheumatoid arthritis and the level of serum D-dimer[J].,2015,8(02):134-137.[doi:10.3969/j.issn.1674-1749.2015.02.002]
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类风湿关节炎中医证型与血浆D-二聚体水平的临床观察()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年02期
页码:
134-137
栏目:
论著
出版日期:
2015-02-06

文章信息/Info

Title:
Clinical observation of relationship between traditional Chinese medidcine syndromes of rheumatoid arthritis and the level of serum D-dimer
作者:
王林; 杨惠民; 李贞玉; 李璐
100700 北京中医药大学东直门医院老年病科[王林(博士研究生)、杨惠民、李贞玉(博士研究生)、李璐(硕士研究生)]
Author(s):
WANG Lin;  YANG Hui-min;  LI Zhen-yu;  et al.
Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China Corresponding author: YANG Hui-min, E-mail: yanghuimin012005@163.com
关键词:
类风湿关节炎;  中医证型;  D-二聚体;  炎症指标
Keywords:
Rheumatoid arthritis;  The TCM syndromes;  D-dimer;  Inflammatory index
分类号:
R593.22
DOI:
10.3969/j.issn.1674-1749.2015.02.002
文献标志码:
A
摘要:
目的 观察不同类风湿关节炎(rheumatoid arthritis, RA)中医证型的患者血浆D-二聚体(D-dimer, DD)水平的差异,并探讨其与血沉(erythrocyte sedimentation rate, ESR)、C反应蛋白(C-reactive protein, CRP)等传统RA炎症指标的相关性。方法 收集90例符合纳入标准的RA病例,采集一般资料、中医证型及DD、ESR、CRP等实验室指标,并对结果进行统计分析。结果 所有入选病例中,DD水平升高者71例,占病例总数的82.2%。其中湿热夹瘀、瘀血痹阻、寒湿痹阻、湿热痹阻、阴虚夹瘀各组中DD水平均显著高于肾气虚寒及肝肾阴虚两组(P<0.01),其余各组间两两比较无统计学差异(P>0.05)。RA患者DD水平与ESR(r=0.573,P<0.01)、CRP(r=0.577,P<0.01)均呈显著正相关。结论(1)RA患者体内DD高于正常水平,且湿热痹阻、瘀血痹阻、寒湿痹阻、湿热夹瘀、阴虚夹瘀型患者DD水平明显高于肾气虚寒、肝肾阴虚型患者,提示RA患者体内凝血/纤溶系统异常与中医学“湿、热、瘀”等实邪有关。(2)RA患者DD水平与ESR、CRP均呈显著正相关性,DD可能成为新的RA活动期检测指标。
Abstract:
Objective The study aims to observe the levels of serum D-Dimer(DD)of patients with different traditional Chinese medicine(TCM)syndromes of rheumatoid arthritis(RA), and explore correlations among DD, erythrocyte sedimentation rate(ESR), C-reactive protein(CRP)and other traditional Inflammatory Markers of RA. Methods 90 RA cases meeting the criteria were collected, of which the epidemiological information, TCM syndromes, level of serum DD, ESR and CRP were analyzed by statistics. Results The level of DD increased in 71 cases, accounted for 82.2% of the total. Among them, levels of DD in groups of damp-heat and blood stasis, static blood blocking collaterals, damp-cold stagnation, damp-heat stagnation and yin deficiency and blood stasis were significantly higher than groups of yang deficiency cold of kidney qi and liver-kidney-yin deficiency(P<0.01). The serum DD level of RA patients was significantly and positively correlated with both ESR(r=0.573, P<0.01)and CRP(r=0.577, P<0.01). Conclusions(1)The level of serum DD in patients with RA were above normal level. Patients of damp-heat and blood stasis group, static blood blocking collaterals group,damp-cold stagnation group, damp-heat stagnation and yin deficiency and blood stasis group were shown a much higher level of DD than yang deficiency cold of kidney qi group and liver-kidney-yin deficiency group, which revealed that the abnormal changes of coagulation and fibrinolysis system of RA patients might be related to the pathogenic excess like damp, heat, blood stasis of TCM syndromes.(2)The serum DD level of RA patients was positively correlated to both ESR and CPR, which could be a new test index of RA.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:北京中医药大学自主选题(2013-JYB22-XS-138) 作者简介:王林(1986- ),2012级在读博士研究生。研究方向:中医风湿病。E-mail: 15001198411@163.com 通讯作者:杨惠民(1957- ),硕士,博士生导师,教授,主任医师。研究方向:中医老年病。E-mail: yanghuimin012005@163.com
更新日期/Last Update: 2015-02-20