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[1]郝蔷薇,麻春杰,乌兰其其格,等.额尔敦—乌日勒对动脉粥样硬化家兔血管内皮因子内皮素、血小板活化因子的影响[J].环球中医药,2015,8(12):1433-1436.[doi:10.3969/j.issn.1674.1749.2015.12.003]
　HAO Qiang-wei,MA Chun-jie,WUlAN Qi-qige,et al.Research on the effect of Eerdun-wurili on rabbit atherosclerotic vulnerable plaque endothelial function[J].,2015,8(12):1433-1436.[doi:10.3969/j.issn.1674.1749.2015.12.003]
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额尔敦—乌日勒对动脉粥样硬化家兔血管内皮因子内皮素、血小板活化因子的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年12期
页码:
1433-1436
栏目:
论著
出版日期:
2015-12-06

文章信息/Info

Title:
Research on the effect of Eerdun-wurili on rabbit atherosclerotic vulnerable plaque endothelial function
作者:
郝蔷薇; 麻春杰; 乌兰其其格; 曾寒泊; 万宇; 田海广
010030 呼和浩特,内蒙古医科大学研究生学院[郝蔷薇(硕士研究生)、麻春杰、乌兰其其格、曾寒泊、田海广]; 广州中医药大学研究生学院(万宇)
Author(s):
HAO Qiang-wei;  MA Chun-jie;  WUlAN Qi-qige;  et al.
The Traditional Chinese Medicine Department of Inner Mongolia Medical University, Hohhot 010030, China
关键词:
额尔敦—乌日勒;  动脉粥样硬化;  血管内皮因子;  内皮功能;  易损斑块
Keywords:
Eerdun-wurili;  Atherosclerosis;  Vascular endothelial factor;  Endothelial function;  Vulnerable plaques
分类号:
R285.5
DOI:
10.3969/j.issn.1674.1749.2015.12.003
文献标志码:
A
摘要:
目的 通过观测额尔敦—乌日勒对动脉粥样硬化家兔血管内皮因子内皮素(endothelin, ET)、血小板活化因子(platelet activating factor,PAF)的影响,明确其稳定斑块的作用机制。方法 将50只家兔,随机分为正常组和造模组。正常组10只不进行造模,普通饲料喂养; 造模组40只采用高脂饮食喂养、免疫损伤、球囊拉伤术复合因素造模,建立家兔动脉粥样硬化易损斑块模型。8周造模成功后,将最终造模成功的29只家兔随机分为模型组(n=10)、额尔敦—乌日勒组(n=10)、辛伐他汀组(n=9),额尔敦—乌日勒组和辛伐他汀组分别给予额尔敦—乌日勒、辛伐他汀进行干预,24周后取材,运用酶联免疫吸附法和免疫组化方法检测各组家兔血管内皮因子PAF和ET的浓度及表达情况。结果 与模型组比较,额尔敦—乌日勒显著降低血清ET、PAF(P<0.01),在降低ET水平上优于辛伐他汀组; 与模型组比较,额尔敦—乌日勒组能降低主动脉ET、PAF表达(P<0.01),在降低ET表达上优于辛伐他汀组(P<0.05)。结论 额尔敦—乌日勒具有改善动脉粥样硬化血管内皮功能的作用。
Abstract:
Objective To explore the effects and possible mechanisms of Eerdun-wurili in stabilizing the vulnerable plaques using a rabbit model of AS vulnerable plaque. Methods We take 50 male New Zealand white rabbit which were underwent balloon-induced abdominal aortic wall injury and were fed a high cholesterol diet for 8 weeks to establish rabbit atherosclerosis model vulnerable plaques; Rabbits were then randomly divided into three groups:the normal group(n=10; General diet without any model); the model group(n=10; without any treatment); the Eerdun-wurili group(n=10; using Eerdun-wurili for treat)and the simvastatin group(n=10; using simvastatin for treat). 24 weeks later, the rabbits were sacrificed to observe concentrations and expressions of ET; PAF expressions were measured by means of Enzyme-linked-immunosorbent assay(ELISA)and immunohistochemistry.Results Elisa test results showed that Eerdun-wurili can significantly reduce the levels of ET and PAF(P<0.01); Rabbit aortic immunohistochemistry results showed: compared to the model group, ET and PAF expressions in the Eerdun-wurili group were significantly reduced(P<0.01); and the ET expression is significantly less than the simvastatin group(P<0.05).Conclusion Eerdun-wurili may though reducing the levels of Endothelial Factor ET and PAF to play the role of anti-AS vulnerable plaques.

参考文献/References:

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备注/Memo

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更新日期/Last Update: 1900-01-01