|本期目录/Table of Contents|

[1]周慧灵,梁婉娴,徐道立,等.迷迭香活性提取物的药理作用研究进展[J].环球中医药,2015,8(12):1542-1545.[doi:10.3969/j.issn.1674.1749.2015.12.037]
　ZHOU Hui-ling,LIANG Wan-xian,XU Dao-li,et al.Research progress on pharmacological action of rosemary active extract[J].,2015,8(12):1542-1545.[doi:10.3969/j.issn.1674.1749.2015.12.037]
点击复制

迷迭香活性提取物的药理作用研究进展()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年12期
页码:
1542-1545
栏目:
综述
出版日期:
2015-12-06

文章信息/Info

Title:
Research progress on pharmacological action of rosemary active extract
作者:
周慧灵; 梁婉娴; 徐道立; 陈雨; 王莹; 赵丕文
100029 北京中医药大学基础医学院[周慧灵(本科生)、梁婉娴(本科生)、徐道立(本科生)、陈雨(本科生)、王莹(本科生)、赵丕文]
Author(s):
ZHOU Hui-ling;  LIANG Wan-xian;  XU Dao-li;  et al.
School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
迷迭香;  活性提取物;  药理作用
Keywords:
Rosemary;  Active extract;  Pharmacological effect
分类号:
R285.5
DOI:
10.3969/j.issn.1674.1749.2015.12.037
文献标志码:
A
摘要:
迷迭香是一种广泛使用的中草药,具有安神、健胃等功效。目前,体内外的研究表明,迷迭香活性提取物具有抗氧化,抑制肝癌细胞、乳腺癌细胞增殖,抑制大肠杆菌、金黄色葡萄球菌、植物病原真菌生长等作用,还具有抗病毒、抗炎、诱导T细胞活化,抗血管形成等作用,对帕金森病、阿尔茨海默病、血管性痴呆也有一定的治疗作用。文章通过查阅国内外资料,对迷迭香活性提取物的药理作用及其机制的研究进展进行综述。
Abstract:
Rosemary is a widely used traditional Chinese herb, which has the effects of tranquillization, regulating stomach and so on. At present, researches in vivo and vitro show that rosemary active extract has many significant pharmacological effects such as anti-oxidation, inhibiting the proliferation of hepatoma carcinoma cells and mammary carcinoma cells, inhibiting the growth of escherichia coli, staphylococcus aureus and plant pathogenic fungi, anti-virus, anti-inflammation, inducing T cell activation, anti-angiogenesis and so on. Meanwhile, rosemary active extract can be used in the treatment of Parkinson's disease, Alzheimer disease and vascular dementia. By referring to the literatures and information both at home and abroad, this article summarizes the pharmacological function and mechanism of rosemary active extract.

参考文献/References:

[1] 王珲.迷迭香化学成分与质量评价研究[D].沈阳:辽宁中医药大学,2011.
[2] 王珲,高慧媛,张振秋,等.中药迷迭香化学成分的分离与鉴定[J].中国现代中药,2011,13(1):23-25.
[3] 贾佳,许璟龙.迷迭香酸的研究现状[J].黑龙江医药,2014,27(2):258-260.
[4] 李霞,杨阳,黄豆豆.甘西鼠尾草药材和提取物中迷迭香酸、丹酚酸B的含量测定[J].中国医院药学杂志,2014,34(19):1635-1638.
[5] 陈頔,张泽生,杨华.迷迭香提取物对D-半乳糖致衰老小鼠氧化损伤的保护作用[J].食品工业科技,2012,14:357-359.
[6] 安晓晶,李雅娟,张红翠,等.迷迭香酸对X射线诱导微血管内皮细胞损伤的保护作用[J].石河子大学学报(自然科学版),2012,30(4):482-487.
[7] 赵云涛,陈绍红,廖艳,等.迷迭香酸对羟自由基所致小鼠肝线粒体损伤的保护作用[J].氨基酸和生物资源,2008,30(4):26-28.
[8] 周建国.迷迭香酸增强5-FU抗肝癌作用研究[D].衡阳:南华大学,2013.
[9] 代海华,宋扬,陈丹丹.刺参酸性黏多糖对5-FU治疗小鼠肝癌的监督增效作用[J].中华肿瘤防治杂志,2015,22(1):23-27.
[10] 杨立芳,雷彩霞,韦玉环,等.田基黄石油醚提取物与5-FU联用对HepG2细胞增殖及凋亡的影响[J].中成药,2014,36(9):1798-1803.
[11] Wust Z. Cytotoxicity of 5-fluorouracil:Effect on endothelial differentiation via cell cycle inhibition in mouse embryonic stem cells[J]. Toxicol In Vitro,2007,54(1):22-28.
[12] Jeremy JJ. Carnosol:A promising anti-cancer and anti-inflammatory agent[J]. Cancer Lett,2011,305(1):1-7.
[13] 刘英华,何宁,姜淑卿,等.雌激素及雌激素受体拮抗剂对人乳腺癌细胞MCF-7中雌激素相关受体表达的影响[J].环境与健康杂志,2011,28(8):677-680.
[14] 刘睿,赵静,张志,等. 雌激素受体亚型ER-α、ER-β在乳腺癌中的表达[J].中国老年学杂志,2012,32(16):3389-3390.
[15] 王健,徐杰,安雪青,等.雌激素促进ER阴性乳腺癌细胞中IL-6的表达[J].南京医科大学学报(自然科学版),2015,35(3):309-314.
[16] 赵丕文,David Yue-Wei LEE,Zhongze Ma,等.鼠尾草酚抗乳腺癌细胞增殖活性及其雌激素受体亚型介导和调节机制的研究[J].中国中药杂志,2014,39(17):3344-3348.
[17] 孙峋,汪靖超,李洪涛,等.迷迭香酸的抗菌机理研究[J].青岛大学学报(自然科学版),2005,18(4):41-45.
[18] 李文茹,施庆珊,莫翠云,等.几种典型植物精油的化学成分与其抗菌活性[J].微生物学通报,2013,40(11):2128-2137.
[19] 柴梦颖,焦镭.15种中草药提取液抑真菌活性的研究[J].农产品加工·学刊,2012,(5):61-64.
[20] 姚旭颖,乔竹稳,单喜臣,等.迷迭香抗植物病原菌活性研究[J].齐齐哈尔大学学报,2012,28(1):61-62.
[21] Dubois M,Bailly F,Mbemba G,et al. Reaction of rosmarinic acid with nitrite ions in acidic conditions:discovery of nitro and dinitrorosmarinic acids as new anti-HIV-1 agents[J]. J Med Chem,2008,51(8):2575-2579.
[22] 李林,黄松明,赵三龙.迷迭香酸对大鼠肾小球系膜细胞增殖中氧化应激及炎症介质分泌的影响[J].实用诊断与治疗杂志,2007,21(12):888-890.
[23] Won J,Hur YG,Hur EM,et al. Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner[J]. Eur J Immunol,2003,(33):870-879.
[24] Park SH,Oh HS,Kang MA,et al. The structure-activity re lationship of the seriesof non-peptide small antagonists for p56lck SH2 domain[J]. Bioorg Med Chem,2007,15(11):3938-3950.
[25] 李雪丽,刘建勋,李澎,等.迷迭香酸对心肌细胞缺氧复氧损伤的保护作用研究[J].中国中药杂志,2014,39(10):1897-1901.
[26] Huang SS,Zheng RL. Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro[J]. Cancer Lett,2006,239(2):271-280.
[27] Kim JH,Lee BJ,Kim JH,et al. Rosmarinic acid suppresses retinal neovascularization via cell cycle arrest with increase of P21(WAF1)expression[J]. Eur J Pharmacology,2009,615(1-3):150-154.
[28] 曲仂.迷迭香酸对铁处理的SK-N-SH细胞的神经保护作用机制研究[D].青岛:青岛大学,2014.
[29] Iuvone T,Defilippis D,Esposito G,et al. The spice sage and its active ingredient reamarinic acid protect PC12 cells from amyloid-β peptide-induced neumtoxicity[J]. J Pharmacol Exp Ther,2006,317(3):1143-1149.
[30] 窦云龙.迷迭香吸嗅对血管性痴呆大鼠学习记忆及海马内5-HT和GABA含量的影响[D].合肥:安徽医科大学,2013.

相似文献/References:

备注/Memo

备注/Memo:
-
更新日期/Last Update: 1900-01-01