[1]国家药典委员会.中华人民共和国药典2010年版一部[M].北京:中国医药科技出版社,2010:164165.
[2]Hinshaw LB.Sepsis/ septic shock:Participation of the microcirculation:An abbreviated review[J].Crit Care Med,1996,249(6):10721078.
[3]国家食品药品监督管理局药品评价中心.英国MHRA警告何首乌的肝损害不良反应[J].中国药物警戒,2006,3(5):313314.
[4]Park GJH, Mann SP, Ngu MC.Acute hepatitis inducedby Shou Wu Pian, a herbal product derived from Polygonum multiforum [J]. J Gastroenterol Hepatol, 2001,16(1):115117.
[5]Panis B,Wong DR, Hooymans PM, et al. Recurrent toxic hepatitis in a Cau casian girl related to the use of Shou Wu Pian,a Chinese herb alpreparat ion [J].J Pediatr Gastroenterol Nutr, 2005,41(2):256258.
[6]Battinelli L,Daniele C,Mazzanti G.New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum mu lt iflorum [J]. Ann Intern Med,2004,140(7):588589.
[7]Cárdenas A, Rest repo J, Sierra F. Acute hepaitis due to Shen Min: a herbal product derived from Polygonum multiflorum [J]. J Clin Gas roenterol, 2006,40(7):629632.
[8]Min HJ, Jung KA, Kim HJ, et al. Twelve cases of toxic hepatitis related to the root of Polygonum multiflorum Thunb [J].J Hepatol,2008,47:S356.
[9]But PP. Tomlinson B, Lee KL .Hepatitis related to the Chinese medicine Shou wu pian manufactured from Polygonum multiflorum [J]. Vet Hum Toxicol,1996,38(4):280282.
[10]Ng KG, Cheng CL, Xu HX,et al. Safety issues of Chinese medicine: a review of Intoxication cases in Hong Kong [J]. Chin Herb Med,2010,1(1):2939.
[11]胡锡琴,耿增岩,李巧兰,等.制何首乌不同剂量与大鼠肝损伤程度的实验研究[J].陕西中医,2007,28(10):1420.
[12]耿增岩,陈金铭,于德红,等. 制何首乌对大鼠肝损伤的实验研究[J].时珍国医国药,2010,21(4):1006.
[13]刘煜德,黄小洵,吴丽莎,等.何首乌肝毒性实验研究[J].亚太传统医药, 2007,(4):7172.
[14]黄伟,张亚囡,孙蓉,等.何首乌不同组分单次给药对小鼠肝毒性“量时毒”关系研究[J].中国药物警戒,2011,8(4):193196.
[15]黄伟,张亚囡,孙蓉,等.何首乌不同组分对小鼠急性毒性试验比较研究[J].中国药物警戒,2010,7(12):705707.
[16]鄢良春,赵军宁,邱雄,等.何首乌安全性问题研究进展[J].中药药理与临床,2009,25(3):7780.
[17]李玥,徐立,刘若囡,等.炮制对何首乌小鼠急性毒性的影响[J].辽宁中医药大学学报,2011,13(5):248249.
[18]夏蕾,王丽霞,牟稷征,等.制何首乌单用或配伍用白蒺藜对小鼠肝脏毒性的比较研究[J].中国药房,2011,22(23):21222124.
[19]胡锡琴,杨红莲,张晓琴,等.制何首乌对大鼠肝脏毒理的实验研究[J].陕西中医,2006,29(3):4041.
[20]胡锡琴,杨晓青,刑玉瑞,等.制何首乌致肝损害的实验研究[J].陕西中医,2006,27(5):625626.
[21]鲁彦,郭建宇,朱贤,等.分光光度法测定大黄中总蒽醌[J].理化检验化学分册,2011,47(3):297299.
[22]白研,黄丽玫,毋福海,等.德庆首乌中蒽醌类成分的含量测定[J].广东药学院学报,2001,17(1):4041.
[23]National Toxicology Program (2001) Technical report on the toxicology andcarcinogenesis studies of emodin in F344/N rats and B6C3F1 mice. Series No.493. NIH Publication No. 013952. U.S. Department of Health and HumanServices, Public Health Service, National Institutes of Health, Research TrianglePark, NC.
[24]孙向红,孙玉维,李红,等.何首乌主要成分大黄素、大黄酸和二苯乙烯苷对肝细胞、肝癌细胞的影响[J].现代中西医结合杂志,2011,19(11):13151318.
[25]王伽伯,马永刚,张萍,等.炮制对大黄化学成分和肝肾毒性的影响及其典型相关分析[J].药学学报,2009,44(8):885890.
[26]Crocenzi FA,Sisti A,Pellgehino JM, et al. Role of bile salts in colchicineinduced hepatotoxicity. Implications for hepatocellular integrity and function [J]. Toxicology, 1997,121(2):127142.
[27]张瑞晨,刘斌,孙震晓,等.何首乌提取物对人正常肝细胞L02周期阻滞及凋亡的影响[J].中西医结合学报,2010,8(6):554560.
[28]王涛,王佳颖,江振洲,等.何首乌水提物大鼠连续灌胃给药28d肝毒性研究—胆汁淤积相关性分析[J].中国中药杂志,2012,37(10):14451449.
[29]Wu XQ,Chen XZ,Huang QC,et al. Toxicity of raw and processed roots of Polygonum multiflorum[J]. Fitoterapia, 2012, 83(3):469475.
[30]陈艳.何首乌炮制程度与内在质量相关性的研究[D].北京:北京中医药大学,2004.
[31]李卫先,张琦,王国仁,等.不同炮制方法炮制的何首乌的质量标准探讨[J].中国医药导报,2012,9(9):4142.
[32]张力,杨晓晖,孙震晓,等.何首乌临床不良事件回顾性研究及风险控制措施探讨[J].中国中药杂志,2009,34(13):17241729.
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