|本期目录/Table of Contents|

[1]孙占学,赵丽娟,张丰川,等.甘石青黛膏对大鼠亚急性湿疹模型皮损的影响[J].环球中医药,2013,6(03):162-0.
　SUN Zhan xue,ZHAO Li juan,LI Yuan wen,et al.Effects of Ganshi Qingdai Cream intervening lesions of subacute eczema model in rats[J].,2013,6(03):162-0.
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甘石青黛膏对大鼠亚急性湿疹模型皮损的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年03期
页码:
162-0
栏目:
论著
出版日期:
2013-03-06

文章信息/Info

Title:
Effects of Ganshi Qingdai Cream intervening lesions of subacute eczema model in rats
作者:
孙占学;赵丽娟;张丰川;李元文;
Author(s):
SUN Zhanxue; ZHAO Lijuan; LI Yuanwen; et al.
Department of Dermatological,DongFang Hospital Affiliated to Beijng University Of Chinese Medicine ,Beijing 100078,China
关键词:
甘石青黛膏; 亚急性湿疹; 大鼠; 疗效评价
Keywords:
Ganshi Qingdai Cream; Subacute eczema; Rat; therapeutic evaluation
分类号:
R2855
DOI:
-
文献标志码:
A
摘要:
目的观察中药甘石青黛膏对大鼠亚急性湿疹模型皮损的治疗效果。方法大鼠亚急性湿疹模型造模成功后进行中药甘石青黛膏干预,并用安慰剂(白凡士林)组进行对照,观察红斑、水肿、表皮剥脱、苔藓化等症状,以湿疹面积及严重度指数评分法评价疗效。结果以湿疹面积及严重度指数评分法比较模型大鼠红斑、水肿、表皮剥脱以及苔藓化等各项数据,甘石青黛膏干预大鼠皮损与本组干预前相比,差异有统计学意义(P<0.01);甘石青黛膏组干预后与安慰剂组模拟治疗后相比差异有统计学意义(P<0.01),甘石青黛膏组症状评分均优于安慰剂组;评价两组湿疹模型干预后总体疗效,安慰剂组总有效率为42.10%,甘石青黛膏组总有效率为72.22%,经统计学处理,差异有统计学意义(P<0.05),甘石青黛膏总体疗效优于安慰组。结论中药甘石青黛膏对亚急性湿疹模型皮损具有控制红斑,消除水肿,促进破损表皮修复,抑制苔藓化的作用。
Abstract:
ObjectiveTo observe the therapeutic effect of Ganshi Qingdai Cream intervening lesions of subacute eczema model in rats. MethodGanshi Qingdai Cream intervening lesions of subacute eczema model in rats,which was to compare with placebo（white vaseline）. The change of lesions from erythema, edema, skin exfoliation, and moss et al as well as eczema area, severity index score were further observed. ResultsThough the means of eczema area, severity index score,the effects of erythema, edema, skin exfoliation, and moss from subacute eczema model of skin lesions in rats treated by Ganshi Qingdai Cream were very good, the difference of effect after treating compared with before treating was significant (P＜001). The effects of erythema, edema, skin exfoliation, and moss from eczema model of skin lesions in rats treated by Ganshi Qingdai Cream were superior to ones of placebo group (P＜001).The total effective rate of placebo group was 4210%, the total effective rate of Ganshi Qingdai Cream was 7222%, by statistical analysis,the total effective rate of Ganshi Qingdai Cream was better than one of placebo,and the difference was significant (P＜005). ConclusionTraditional Chinese medicine Ganshi Qingdai Cream could control erythema, eliminate edema, repair the damaged epidermis, inhibit moss role of eczema model of skin lesions in rats.

参考文献/References:

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［2］Boyera N, Caver D,Bouclier M, et al.Repeated application of dinitrochlorobenze to the ears of sensitized guinea pigs: Apreliminary characterization of a potential new animal model for contact eczema in humans［J］.Skin Pharmacol，1992，5(3)：184188.
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［4］赵辨. 湿疹面积及严重度指数评分法［J］. 中华皮肤科杂志,2004,37(1):34.
［5］BerthJones J. Six area six sign atopic dermatitis(SASSAD) severity score: a simple system for monitoring disease activity in atopic dermatitis［J］. Br J Dermatol, 1996,135 (Suppl48):2530.
［6］Fuchibe K Nabe T，Fujii M，et a1．Delayed type allergic itchassociated response induced by toluene2,4diisocyanate in hairless mice［J］．J Pharmacol Sci,2003,93(1):4754.
［7］李楠,张丰川,李元文.复方甘石青黛膏治疗皮炎湿疹的临床观察［J］.环球中医药,2009，2（4）：280281.
［8］孙占学,李元文,李曰庆,等.甘石青黛膏治疗神经性皮炎66例临床疗效观察［J］.中华中医药杂志, 2010，25（11）：18491851.

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备注/Memo

备注/Memo:
基金资助：国家“十一五”科技支撑计划 (2008BAI53B045)；北京市中医药科技项目（YNZJ201102）；北京中医药大学自主选题（JYB22JS047）
作者单位：100078 北京中医药大学东方医院皮肤科(孙占学、张丰川、李元文）；云南省中医医院皮肤科(赵丽娟）
作者简介：孙占学（1973-），博士，主治中医师。研究方向：变态免疫性皮肤病。Email:sunzhanxue@163.com
通讯作者：李元文（1962-），主任中医师，教授，博士生导师，中国性学会中医性学专业委员会主任委员兼秘书长，北京中医药学会皮肤性病专业委员会副主任委员。研究方向：中医皮肤性病学。Email：liyuanwen@medmail.com.cn
更新日期/Last Update: 1900-01-01