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[1]辛明蔚 刘雁峰 骆斌等.交通心肾法对老龄雌性大鼠性激素水平的影响[J].环球中医药,2014,7(04):258-0.
　XIN Ming wei,LIU Yan feng,LUO Bin,et al.Effect of the method of promoting heartkidney interaction on sex hormone level in old female rats[J].,2014,7(04):258-0.
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交通心肾法对老龄雌性大鼠性激素水平的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年04期
页码:
258-0
栏目:
论著
出版日期:
2014-04-06

文章信息/Info

Title:
Effect of the method of promoting heartkidney interaction on sex hormone level in old female rats
作者:
辛明蔚 刘雁峰 骆斌等
Author(s):
XIN Mingwei; LIU Yanfeng; LUO Bin; et al.
Department of traditional Chinese medicine, Beijing Obstetrics Gynecology Hospital，Capital Medical University，Beijing 100026，China
关键词:
交通心肾法:6540; 雌性大鼠:5852; 性激素水平:4166; 老龄:2342; 雁峰:338
Keywords:
Method of promoting heartkidney interaction; Old female rats; Sex hormone levels
分类号:
R2855
DOI:
-
文献标志码:
A
摘要:
目的探讨交通心肾法中药对老龄雌性大鼠性激素水平的影响。方法选用15月龄雌性SD大鼠，将其分为空白组、中药治疗组、西药对照组和中药对照组，分别给予生理盐水、宁更丹、戊酸雌二醇和更年安灌胃，另选3月龄大鼠作为青年对照组。采用放射免疫法检测大鼠促卵泡刺激素(follicle stimulating hormone，FSH)、促黄体生成素(luteinizing hormone，LH)、雌二醇(estradiol，E2)。结果与空白组比较，中药治疗组雌激素明显升高，有显著性差异（P<005），且与西药对照组结果类似。中药对照组雌激素水平略有升高，但与空白组相比无显著性差异。中药治疗组、西药对照组、中药对照组FSH均有降低，与空白组均有显著性差异（P<005），但是西药对照组下降更为显著。结论交通心肾法可以升高老龄雌性大鼠雌激素，降低FSH水平，可能是其治疗更年期综合征的作用机制之一。
Abstract:
ObjectiveStudy the Method of promoting heartkidney interaction herbs on influencing the sex hormone levels in old female rats. Methods Choose female SD rats aged 15 months. They were divided into blank group , Chinese medicine treatment group, western medicine control group, Chinese medicine control group , and they were given normal saline, Ning Gengdan, progynova and Gengnianan gavage treatment respectively, Another 3 months old rats were chosen as the young control group. MethodsRadioimmunoassay was used to measure the levels of follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2). ResultsCompared with the blank group, Groups treated by Chinese herbs in rats with estrogen levels were markedly elevated, which have significant difference between two groups (P<005) . The western medicine control group have similar results. Traditional Chinese medicine control group slightly elevated levels of estrogen, but there was no significant difference compared with the blank group. Chinese medicine treatment group, western medicine control group, and Chinese medicine control group rats FSH levels were decreased, which have significant difference compared with the blank group（P<005）, but the comparison group decreased more significantly. ConclusionMethod of promoting heartkidney interaction can increase the estrogen in aged female rats, decrease the level of FSH, which may be one of the mechanisms of the treatment of menopausal syndrome.

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备注/Memo

备注/Memo:
基金项目：北京市自然科学基金（7112070）；北京中医药大学证候规范化标准化创新团队基金（2011CXTD08）
作者单位：100026 北京，首都医科大学附属北京妇产医院中医科（辛明蔚、武颖）；北京中医药大学东直门医院妇科［辛明蔚(博士研究生)、刘雁峰、江媚（博士研究生）、孙天琳（博士研究生）、苏恒香（硕士研究生）］；北京中医药大学基础医学院（骆斌）
作者简介：辛明蔚（1980），女，2012级在职博士研究生，主治医师。研究方向：中医药防治女性生殖内分泌疾病。Email：xinmingwei@126.com
通讯作者：刘雁峰（1963），女，博士，主任医师，教授，博士生导师。研究方向：中医药防治女性生殖内分泌疾病、不孕症等。Email：liuyaf888@sina.com
更新日期/Last Update: 1900-01-01