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[1]宋宜祥 黎巍威 王学美.淫羊藿苷神经保护作用机制研究进展[J].环球中医药,2014,7(04):300-0.
　SONG Yi xiang,LI Wei wei,WANG Xue mei..Adances in neuroprotective effects mechanisms of Icariin[J].,2014,7(04):300-0.
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淫羊藿苷神经保护作用机制研究进展()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年04期
页码:
300-0
栏目:
综述
出版日期:
2014-04-06

文章信息/Info

Title:
Adances in neuroprotective effects mechanisms of Icariin
作者:
宋宜祥 黎巍威 王学美
Author(s):
SONG Yixiang; LI Weiwei; WANG Xuemei.
Eastwest Integrative Medicine Research Center, Peking University First Hospital, Beijing 100034, China
关键词:
淫羊藿苷:6506; 神经保护:5170; 作用机制:4157; 研究进展:3669; 王学:424
Keywords:
Icariin; Neuroprotective effects; Antioxidant; Cytokine
分类号:
R285
DOI:
-
文献标志码:
A
摘要:
淫羊藿苷是中药淫羊藿的主要活性成分，具有抗肿瘤、增强免疫、改善心脑血管、调节内分泌等多重药理学作用。近年来关于淫羊藿苷对中枢神经系统保护作用的研究日益增多，为了进一步推进淫羊藿苷对于防治中枢神经系统疾病的研究，本文结合近十年国内外对其保护神经元细胞的研究报道，系统地总结和陈述了淫羊藿苷发挥保护神经作用的几个途径，主要包括抗氧化应激、抑制炎症反应、影响单胺类递质及氨基酸类神经递质的释放、增加神经营养作用等几个方面，以及探讨了淫羊藿苷发挥神经保护作用的信号转导机制，为进一步推进淫羊藿苷的研究作出理论支持。
Abstract:
Icariin is one of the most dynamic composition of Epimedium, which has pharmacological functions of inhibiting tumor, enhancing immunity, improving heart and cerebral vessels, and regulating endocrine function. In recent years，researches on neuroprotective effects of icariin in central nervous system have been increased . To further promote the researches on prevention and cure on central nervous system diseases，this review systematically summarizes the neuroprotective effects of icariin on neurons including the mechanism combined with research reports of Icariin at home and abroad, which include the following, antioxigenic stess, inhibiting the inflammatory response, adjusting the release of neurotransmitter of monoamines and amino acids, and increasing neurotrophic effect. The signal transduction mechanism of icariins neuroprotective effect is also discussed, which may provide useful theoretical support to the research of icariin.

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相似文献/References:

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81102683、81173369）；教育部博士点基金（20120001110105、20110001120055）；北京市自然科学基金（7132210）
作者单位：100034 北京大学第一医院中西医结合教研室\[宋宜祥（硕士研究生）、黎巍威、王学美\]
作者简介：宋宜祥(1987 )，2011级在读硕士研究生。研究方向：中西医结合防治老年病。Email:syx12319@126.com
通讯作者：王学美(1964 )，女，博士，主任医师，博士生导师。中国中西医结合学会常务理事，中国中西医结合学会糖尿病专业委员会副主任委员，世界中医药学会联合会心血管专业委员会理事。研究方向：中西医结合防治老年病。Email:wangxuemeibjmu@163.com
更新日期/Last Update: 1900-01-01