|本期目录/Table of Contents|

[1]王群 吴志鸿.鱼腥草滴眼液眼局部应用的安全性研究[J].环球中医药,2014,7(09):697-0.
　WANG Qun,WU Zhi-hong..Research on the ocular safety of Houttuynia cordata Thunb eye drops application[J].,2014,7(09):697-0.
点击复制

鱼腥草滴眼液眼局部应用的安全性研究()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年09期
页码:
697-0
栏目:
论著
出版日期:
2014-09-06

文章信息/Info

Title:
Research on the ocular safety of Houttuynia cordata Thunb eye drops application
作者:
王群 吴志鸿
Author(s):
WANG Qun; WU Zhi-hong.
Ophthalmology Department, General Hospital of The Armed Police Forces, Beijing 100039, China
关键词:
鱼腥草滴眼液;  安全性;  角膜
Keywords:
Houttuynia cordata thunb eye drops;  Safety;  Cornea
分类号:
R276.7
DOI:
-
文献标志码:
A
摘要:
目的 研究鱼腥草滴眼液眼局部应用的安全性。方法 20只SD大鼠按照随机数字表法分为对照组和实验组,以生理盐水滴眼为对照,鱼腥草滴眼液滴眼为实验组,每日滴眼4次,共14天。观察局部点眼后大鼠的刺激症状,裂隙灯显微镜观察眼表组织的形态学变化,HE染色光镜检查大鼠角膜用药后眼表结膜、角膜组织的炎症发生情况。结果 两组大鼠接受滴眼液点眼后,无明显行为学改变,无明显刺激症状。两组大鼠Draize刺激实验评分用χ2检验后发现差异无统计学意义(P>0.05)。裂隙灯观察未发现眼表和眼前节组织有明显异常。病理切片HE染色检查发现两组大鼠结膜和角膜上皮完整,基质排列有序规则,未发现明显炎性细胞浸润。结论 鱼腥草滴眼液眼局部应用安全性良好。
Abstract:
Objective To evaluate the ocular safety of Houttuynia cordata Thunb eye drops application.Methods 20 SD rats were randomly divided into two groups: the control group and the test group. In the control group, normal saline was used as the eye drops. In the test group, Houttuynia cordata Thunb eye drops were applied. The eye drops were given 4 times a day for 14 days. The behavior and irritation changes of the rats were observed.Slit lamp corneal microscope examination was used to analyze the changes of the conjunctiva, cornea and iris. HE staining was used to analyze the changes of the ocular tissues.Results There were no changes in the behavior of the rats in both groups. There were no obvious irritation changes of the ocular tissues. There was no statistical difference in two groups on the scores from Draize system by χ2 test. Slit lamp corneal microscope examination showed that there were no obvious changes in the ocular surface and anterior segment. HE staining demonstrated that in the ocular tissues in both groups were both abnormal after the application of eye drops.Conclusion The application of Houttuynia cordata Thunb eye drops on cornea was safe.

参考文献/References:

[1] 孙思邈.银海精微[M].北京:人民卫生出版社,1955:17-18.
[2]杨磊.鱼腥草滴眼液的制备及临床应用[J].中国药业,2006,15(11):47.
[3]王 本祥.现代中药药理学[M].天津:科技技术出版 社,1997: 252- 257.
[4]李翔,王明芳,肖放,等.鱼腥草滴眼液治疗流行性角膜结膜炎[J].中国中医眼科杂志,2000,10(4):211- 214.
[5]李翔,王明芳,谢学军,等.鱼腥草滴眼液治疗急性卡他性结膜炎[J].眼科新进展,2001,21(6):417- 419.
[6]赵海滨,彭清华,吴权龙,等.鱼腥草滴眼液治疗单纯疱疹性角膜炎的实验研究[J].中国中医眼科杂志,2002,12(3):129-131.
[7]NAS committee for the revision of NAS Publication. Principles and Procedures for Evaluating the Toxitity of House-hold Substances[M].Washington.D.C., National Academy of sciences,1977:41- 54.
[8]石磊. 靶向Bcl-2小分子化合物纳米悬混液对碱烧伤诱导的大鼠角膜新生血管的抑制作用及其作用机制研究[D]. 北京:解放军医学院,2013:17- 20.

相似文献/References:

[1]乔佛晓,禹玉洪,李燕.荜茇的药理作用与毒性作用研究概述[J].环球中医药,2015,8(04):507.[doi:10.3969/j.issn.1674-1749.2015.04.038]
　QIAO Fo-xiao,YU Yu-hong,LI-Yan..Overview of pharmacological action and toxic effects of Piper Longum[J].,2015,8(09):507.[doi:10.3969/j.issn.1674-1749.2015.04.038]
[2]贾海忠 赵进喜 梁腾霄 关秋红 肖永华 刘宁 黄茂 刘鑫源 王若溪.辨证运用中药注射剂,保证临床用药安全有效[J].环球中医药,2016,9(08):949.[doi:10.3969/j.issn.1674-1749.2016.08.012]
[3]巴哈尔古丽·力提甫,陈慕芝.中医辨证联合免疫抑制剂治疗活动性类风湿关节炎患者65例[J].环球中医药,2016,9(09):1119.[doi:10.3969/j.issn.1674-1749.2016.09.029]
[4]李志坚.灌肠汤联合山莨菪碱治疗小儿肠套叠100例[J].环球中医药,2016,9(10):1235.[doi:10.3969/j.issn.1674-1749.2016.10.022]

备注/Memo

备注/Memo:

作者单位:100039 北京,武警总医院眼科
作者简介:王群(1984- ),博士,医师。研究方向:角膜病和眼底病。E-mail:emilywang1984@msn.com 通讯作者:吴志鸿(1963- ),博士,主任医师。研究方向:角膜病和青光眼。E-mail:fswuzhihong@sina.com
更新日期/Last Update: 1900-01-01