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[1]郭文鹏,戎志斌,尚業.“膀胱癌湿热瘀毒蕴积病因病机与其有氧糖酵解代谢异常相关”假说的提出[J].环球中医药,2015,8(01):59-62.[doi:10.3969/j.issn.1674-1749.2015.01.014]
　GUO Wen-peng,RONG Zhi-bin,SHEUNG Yip.The hypothesis on the correlation between bladder cancer's damp-heat-blood stasis-toxin accumulation etiology and pathogenesis and the metabolic disorders in its aerobic glycolysis[J].,2015,8(01):59-62.[doi:10.3969/j.issn.1674-1749.2015.01.014]
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“膀胱癌湿热瘀毒蕴积病因病机与其有氧糖酵解代谢异常相关”假说的提出()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年01期
页码:
59-62
栏目:
理论探讨
出版日期:
2015-01-06

文章信息/Info

Title:
The hypothesis on the correlation between bladder cancer's damp-heat-blood stasis-toxin accumulation etiology and pathogenesis and the metabolic disorders in its aerobic glycolysis
作者:
郭文鹏; 戎志斌; 尚業
518035 深圳大学第一附属医院中心实验室(郭文鹏); 香港大学化学系(郭文鹏、尚業); 中国中医科学院广安门医院脾胃科(戎志斌)
Author(s):
GUO Wen-peng; RONG Zhi-bin; SHEUNG Yip
Department of Central Laboratory, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035,China Corresponding author: SHEUNG Yip,E-mail:y.sheung@ymail.com
关键词:
膀胱癌;  病因病机;  有氧糖酵解;  中医
Keywords:
Bladder cancer;  Etiology and pathogenesis;  Aerobic glycolysis;  Traditional Chinese Medicine
分类号:
R332.6+2
DOI:
10.3969/j.issn.1674-1749.2015.01.014
文献标志码:
A
摘要:
传统中医认为,在肿瘤的发生发展过程中“虚、痰、瘀、毒”是其主要病因病机,而正气虚弱是疾病发生的基础,《灵枢·水胀》中也记载“恶气乃起,息肉乃生”。因此,“虚、痰、瘀、毒”和机体相互作用产生“恶气”,从而导致肿瘤。作者前期对膀胱癌的研究中,发现肿瘤细胞有氧糖酵解代谢异常过程可提供其持续生长的物质(核酸、磷脂、氨基酸、乳酸等)和能量(ATP),并且和细胞生长环境中的H+、HCO3-、O2等密切作用。结合中医肿瘤学“虚、痰、瘀、毒”的辨证认识和膀胱的脏腑特性,本文提出“膀胱癌湿热瘀毒蕴积病因病机与其有氧糖酵解代谢异常相关”的假说。
Abstract:
Traditional Chinese Medicine(TCM)regards “Deficiency, Phlegm, Blood stasis, Toxin” as the main etiology and pathogenesis in the formation and development of tumors, and the weakness of healthy Qi is the basis of diseases, as is recorded in The Miraculous Pivot·Shui Zhang that “the filthy energy will begin to rise, the polypus will begin to grow”. The interaction between “Deficiency, Phlegm, Blood stasis, Toxin” and human body generates “filthy energy” and thus leads to tumor. Previous researches on bladder cancer by the authors of this article reveal that metabolic disorders in the aerobic glycolysis of tumor cells provides tumor cells with growth materials(nuclei acid, lecithin, amino acid, lactic acid, etc)and energy which interact with H+, HCO3- and O2 in the growth environment of tumor cells. Based on the dialectical knowledge of “Deficiency, Phlegm, Blood stasis, Toxin” in TCM oncology and the Zang-Fu traits of bladder, a hypothesis on the correlation between bladder cancer's damp-heat-blood stasis-toxin accumulation etiology and pathogenesis and the metabolic disorders in its aerobic glycolysis is proposed in this article.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81301739); 广东省自然科学基金(S2013040012629); 深圳市科技创新委员会基础研究项目(JCYJ20130401105658431) 作者简介:郭文鹏(1981- ),博士,副研究员。研究方向:中医肿瘤学。E-mail:guowp2006@hotmail.com 通讯作者:尚業(1981- ),博士,副研究员。研究方向:分析化学及中医药分析。E-mail: y.sheung@ymail.com
更新日期/Last Update: 2015-01-05