|本期目录/Table of Contents|

[1]戴卫平,李耿,申小花,等.众生丸对H1N1流感小鼠的保护及免疫调节作用研究[J].环球中医药,2015,8(04):395-399.[doi:10.3969/j.issn.1674-1749.2015.04.003]
　DAI Wei-ping,LI Geng,SHEN Xiao-hua,et al.Protection and immunoregulation of Zhongsheng Pill on mice infected with H1N1 virus[J].,2015,8(04):395-399.[doi:10.3969/j.issn.1674-1749.2015.04.003]
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众生丸对H1N1流感小鼠的保护及免疫调节作用研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年04期
页码:
395-399
栏目:
论著
出版日期:
2015-04-06

文章信息/Info

Title:
Protection and immunoregulation of Zhongsheng Pill on mice infected with H1N1 virus
作者:
戴卫平; 李耿; 申小花; 吴依娜; 张奉学; 赖小平
作者单位:510006 广州中医药大学中药学院[戴卫平(硕士研究生)、李耿、申小花、吴依娜]; 广州中医药大学热带医学研究所(张奉学); 东莞广州中医药大学中医药数理工程研究院(赖小平)
Author(s):
DAI Wei-ping; LI Geng; SHEN Xiao-hua; et al.
School of Chinese Herbal Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China Corresponding author:LAI Xiao-ping,E-mail:lxp88@gzhtcm.edu.cn
关键词:
众生丸;  H1N1亚型流感病毒;  炎症;  免疫;  细胞因子
Keywords:
Zhongsheng Pill;  H1N1 influenza virus;  Inflammation;  Immunization;  Cytokine
分类号:
R285.5
DOI:
10.3969/j.issn.1674-1749.2015.04.003
文献标志码:
A
摘要:
目的 研究众生丸对H1N1流感病毒感染小鼠的保护及免疫调节作用。方法 以奥司他韦为阳性药,H1N1流感病毒滴鼻感染小鼠复制小鼠病毒性肺炎模型。比较小鼠病毒性肺炎模型的肺指数、肺组织形态学、死亡保护率、小鼠T淋巴细胞亚群和细胞因子干扰素-γ(Interferon-γ, IFN-γ)、白细胞介素-10(interleukin-10, IL-10)的数量变化。结果 与病毒对照组比较,众生丸可显著降低H1N1感染小鼠的肺指数,提高存活率,调节T细胞亚群含量,促进血清中IFN-γ和IL-10产生。结论 众生丸可通过减轻炎症,调节免疫而减轻H1N1亚型流感病毒所致小鼠肺部病变,提高染毒小鼠存活率。
Abstract:
Objective To study the protection and Immunomodulatory mechanism of Zhongsheng Pill on mice infected with H1N1 influenza virus. Methods The model of viral pneumonia was established by dripping H1N1 virus nasally in mice, with Tamiflu as the positive drug. The lung index, histologic and morphologic changes of lungs, survival rate, the levels of T lymphocyte subpopulation, Interferon-γ(IFN-γ)and interleukin-10(IL-10)in mice model were investigated. Results Compared with the control group, the model group treated with Zhongsheng Pill was shown a reduced level of lung index, increased survival rate, regulated level of T lymphocyte subpopulation, induced production of IFN-γ and IL-10. Conclusion Zhongsheng Pill can improve the survival rate through relieving the inflammation and regulating the immune function to reduce the lung lesions caused by H1N1 influenza virus.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:广东省自然科学基金(S2012030006598); 广东省科技计划(2010A032100006); 东莞市科技局项目(2011108102048) 作者简介:戴卫平(1989- ),2012级在读硕士研究生。研究方向:中药药效物质基础研究。E-mail: 314841760@qq.com 通讯作者:赖小平(1960- ),博士,研究员,博士生导师。研究方向:中药新药研究与开发。E-mail:lxp88@gzhtcm.edu.cn
更新日期/Last Update: 2015-04-20