[1]彭尹宣,王兴,杨娟,等.天麻多糖对天麻钩藤药对效应成分吸收的影响[J].环球中医药,2015,8(12):1452-1454.[doi:10.3969/j.issn.1674.1749.2015.12.007]
PENG Yin-xuan,WANG Xing,YANG Juan,et al.Influence of polysaccharide of tall gastrodia tuber on absorption of effective components in medicine suits of tall gastrodia tuber and gambir plant nod[J].,2015,8(12):1452-1454.[doi:10.3969/j.issn.1674.1749.2015.12.007]
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天麻多糖对天麻钩藤药对效应成分吸收的影响(
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PENG Yin-xuan,WANG Xing,YANG Juan,et al.Influence of polysaccharide of tall gastrodia tuber on absorption of effective components in medicine suits of tall gastrodia tuber and gambir plant nod[J].,2015,8(12):1452-1454.[doi:10.3969/j.issn.1674.1749.2015.12.007]
)《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]
- 卷:
- 第8卷
- 期数:
- 2015年12期
- 页码:
- 1452-1454
- 栏目:
- 论著
- 出版日期:
- 2015-12-06
文章信息/Info
- Title:
- Influence of polysaccharide of tall gastrodia tuber on absorption of effective components in medicine suits of tall gastrodia tuber and gambir plant nod
- Author(s):
- PENG Yin-xuan; WANG Xing; YANG Juan; et al.
- School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
- 分类号:
- R285.5
- 文献标志码:
- A
- 摘要:
- 目的 研究天麻多糖对天麻钩藤药对效应成分天麻素吸收的影响。方法 采用高效液相色谱法测定天麻钩藤水煎液组和去多糖天麻钩藤水煎液组中的天麻素在不同时间点大鼠血浆中的含量; 色谱柱:Agilent SB-C18 4.6×250 mm,5 μm; 流动相:乙腈-0.1%磷酸水溶液(1.6:98.4); 检测波长:220 nm; 柱温:30℃; 流速:1.0 mL/min; 进样量:20 μL。结果 去多糖组中天麻素的吸收速率常数(ka)和达峰浓度(Cmax)明显小于天麻钩藤水煎组,而达峰时间(Tmax)比天麻钩藤水煎液组长; 天麻钩藤水煎液组中天麻素的半衰期(T1/2)明显比去多糖组长且天麻钩藤水煎组始终维持着较高的药物浓度,说明在去除天麻多糖后,大鼠对天麻钩藤药对中的效应成分天麻素的吸收效率明显降低,且天麻钩藤水煎组的曲线下面积(AUC)明显比去多糖组大。结论 天麻多糖对天麻钩藤药对中的效应成分天麻素的吸收具有促进作用。
- Abstract:
- Objective To study the influence of polysaccharide of tall gastrodia tuber on absorption of gastrodin in medicine suits of tall gastrodia tuber and gambir plant nod. Methods High Performance Liquid Chromatography(HPLC)was used to determine the content of gastrodin in different time points of rat plasma in tall gastrodia tuber and gambir plant nod decoction group(TG group)and tall gastrodia tuber and gambir plant nod without polysaccharide decoction group(TGP group), and with the determination conditions were as following: determination column was Agilent SB-C18 4.6×250 mm, 5 μm; the mobile phase was consisted with acetonitrile-0.1% phosphoric acid(1.6:98.4); determine wavelength was 220 nm; column temperature was 30℃; flow velocity was 1.0 mL/min; loading quantity of sample was 20 μL. Resluts Compared with TG group, the ka and Cmax of TGP group were smaller, and the Tmax was longer obviously. Compared with TGP group, the T1/2 was longer, and drug concentration had always been maintained at a higher level. It showed that the absorption efficiency of gastrodin in medicine suits of tall gastrodia tuber and gambir plant nod absorbed by rats was decreased significantly after removing of polysaccharide of tall gastrodia tuber, and the area under the curve(AUC)of TG group was significantly lager than that of TGP group. Conclusion Polysaccharides of tall gastrodia tuber could facilitate the absorption of gastrodin, which was an effective components in medicine suits of tall gastrodia tuber and gambir plant nod.
参考文献/References:
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