|本期目录/Table of Contents|

[1]宋志勇.地黄和胃口服液对大鼠血液及生化指标的影响[J].环球中医药,2016,9(04):390-393.[doi:10.3969/j.issn.1674-1749.2016.04.002]
　SONG Zhi-yong..The effect of Dihuang Hewei oral liquid on the blood and biochemical criterion of rats[J].,2016,9(04):390-393.[doi:10.3969/j.issn.1674-1749.2016.04.002]
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地黄和胃口服液对大鼠血液及生化指标的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年04期
页码:
390-393
栏目:
论著
出版日期:
2016-04-06

文章信息/Info

Title:
The effect of Dihuang Hewei oral liquid on the blood and biochemical criterion of rats
作者:
宋志勇
064199 唐山,玉田县中医医院制剂科
Author(s):
SONG Zhi-yong.
Hebei Province Yutian County Hospital of Traditional Chinese Medicine Preparation Department, Tangshan 064199, China
关键词:
地黄和胃口服液;  大鼠;  毒性
Keywords:
Dihuanghewei oral liquid;  Rats;  Toxicity
分类号:
R285.5
DOI:
10.3969/j.issn.1674-1749.2016.04.002
文献标志码:
A
摘要:
目的 探讨地黄和胃口服液对大鼠体重、血液、生化指标的影响,为临床用药提供参考。 方法 将大鼠随机分为4组,分别为对照组、地黄和胃口服液低剂量组(1.3 g/kg,相当于临床用药的16.88倍)、地黄和胃口服液中剂量组(2.6 g/kg,相当于临床用药的33.76倍)、地黄和胃口服液高剂量组(5.2 g/kg,相当于临床用药的67.52倍),每组20只。适应性喂养1周后,开始灌胃给药(生理盐水),各剂量组大鼠分别于每天上午8点至10点、下午14点至16点灌胃,每周定时给药7天,并称重1次,根据体重变化调整给药量,连续给药3个月 。各组于给药结束后取10只进行检查,剩余10只大鼠作恢复期观察2周。 结果 地黄和胃口服液各剂量组(1.3 g/kg、2.6 g/kg、5.2 g/kg)大鼠在3个月试验期及恢复期内,体重增长与对照组基本一致。对大鼠血液学指标、血液生化指标、主要脏器系数的影响,均在正常生理范围之内,其他各组均未见明显差异(P<0.05)。结论 地黄和胃口服液对大鼠未见明显毒性作用。
Abstract:
Objective To explore the effect of Dihuang Hewei oral liquid on the weight, blood and biochemical criterion of rats, and to provide a reference for clinical. Methods The rats were ramdomly divided into control group, Dihuang Hewei oral liquid low group(1.3 g/kg, equivalent to 16.88 times of clinical application), Dihuang Hewei oral liquid middle group(2.6 g/kg, equivalent to 33.76 times of clinical application), Dihuang Hewei oral liquid high group(5.2 g/kg, equivalent to 67.52 times of clinical application), 20 in each. After 1 week of adaptation, the rats were given medicine(water). The rats were received gavage at 8 to 10 in the morning and 14 to 16 in the afternoon. The medicine was administrated for 7 days and the rats were weighed once a week. The dose should be adjusted according to the change of weight. This process should last for three months. After 3 months of treatment, 10 rats were taken for examination, and the remaining 10 rats were observed for 2 weeks. Results The weight growth of rats in all Dihuang Hewei oral liquid(1.3g/kg、2.6g/kg、5.2g/kg )groups were similar to the control group at the 3 months of experiment period and recovery period. The effect on the haematological index, blood biochemical index and main organ coefficients of the rats were all in normal physiological range. No significant difference was found in other groups(P<0.05). Conclusion Dihuang Hewei oral liquid has no obvious toxic effects on rats.

参考文献/References:

[1] 宋志勇,王蕊,张金凤,等.地黄和胃口服液对小鼠的急性毒性实验[J].内蒙古中医药,2014, 33(35):110.
[2] 陈奇.中药药理研究方法学[M].北京:人民卫生出版社,1993:112-120.
[3] 中华人民共和国卫生部药政管理局.中药西药研究指南[M].北京:人民卫生出版社,1994:203-205.
[4] 王盟,孙清海,刘卫.钩藤总碱缓释滴丸的长期毒性试验研究[J].国际中医中药杂志,2014, 36(10):905-908.
[5] 宋志勇.地黄和胃口服液对糖尿病大鼠糖耐量的改善作用[J].河北中医,2014,36(7):1074-1075.

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备注/Memo

备注/Memo:
基金项目: 河北省中医药管理局2015年度科研计划项目(2015256)
作者简介: 宋志勇(1963- ),本科,副主任药师。研究方向:中药制剂。E-mail:szy6159645@163.com
更新日期/Last Update: 2016-04-06