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[1]张超 仇峰 李静 王满元 龚慕辛.青蒿乙素、青蒿酸和东莨菪内酯三组分对青蒿素在疟疾小鼠体内药动学行为的影响[J].环球中医药,2016,9(04):394-398.[doi:10.3969/j.issn.1674-1749.2016.04.003]
　ZHANG Chao,QIU Feng,LI Jing,et al.The effects of arteannuin B,arteannuic acid and scopoletinon pharmacokinetics of artemisinin in mice infected by Plasmodium yoelii[J].,2016,9(04):394-398.[doi:10.3969/j.issn.1674-1749.2016.04.003]
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青蒿乙素、青蒿酸和东莨菪内酯三组分对青蒿素 在疟疾小鼠体内药动学行为的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年04期
页码:
394-398
栏目:
论著
出版日期:
2016-04-06

文章信息/Info

Title:
The effects of arteannuin B,arteannuic acid and scopoletinon pharmacokinetics of artemisinin in mice infected by Plasmodium yoelii
作者:
张超 仇峰 李静 王满元 龚慕辛
100069 北京,首都医科大学中医药学院[张超(硕士研究生)、仇峰、李静、王满元、龚慕辛]
Author(s):
ZHANG Chao;  QIU Feng;  LI Jing;  et al.
School of Traditional Chinese Medicine,Capital Medical University, Beijing 100069, China
关键词:
青蒿素;  青蒿;  协同增效组分;  药物动力学;  小鼠疟疾模型
Keywords:
Artemisinin;  Artemisia annua L.;  Synergistic components;  Pharmacokinetic;  Mouse model of malaria
分类号:
R285.5
DOI:
10.3969/j.issn.1674-1749.2016.04.003
文献标志码:
A
摘要:
目的 探究青蒿乙素、青蒿酸和东莨菪内酯三组分在疟疾小鼠体内对青蒿素抗疟增效作用在药物动力学方面可能的影响及其规律,为开发新型基于青蒿素类抗疟药的联合治疗方案药物奠定基础。方法 分别对疟疾小鼠灌胃给予青蒿素(100 mg/kg)和青蒿素、青蒿酸、青蒿乙素和东莨菪内酯联用(每种组分各100 mg/kg),于给药后不同时间点采集血浆,样品经液-液萃取后,采用HPLC-MS/MS法测定药物浓度。结果 与青蒿素单用比较,青蒿素、青蒿乙素、青蒿酸和东莨菪内酯联用组青蒿素的最大血药浓度由924 ng/mL 增加到1065 ng/mL,AUC(0-t)(1893 h×ng/mL)明显高于青蒿素单用组(661 h×ng/mL),半衰期延长,血浆清除率下降了65%。结论 青蒿乙素、青蒿酸和东莨菪内酯可显著影响青蒿素的药物动力学行为。
Abstract:
Objective To explore the antimalaria synergistic effects of arteannuin B, arteannuic acid and scopoletin on the pharmacokinetics of artemisinin in mice infected by Plasmodium yoelii. Method Mice infected by Plasmodium yoelii were given artemisinin or a combination of artemisinin、arteannuin B、arteannuic acid and scopoletin. Blood samples were collected at different time intervals and extracted by liquid-liquid extraction. The contents in plasma were detected by HPLC-MS/MS method. Results Compared to single artemisinin group, the Cmax of the combination group was increased from 924 ng/mL to 1065 ng/mL,AUC(0-t)(1893 h×ng/mL), and the maximum plasma concentration was significantly higher than that of single artemisinin group(661 h×ng/mL), the biological half life was extended, and the CLtot was reduced at a proportion of 65%. Conclution Arteannuin B、arteannuic acid and scopoletin can obviously affect pharmacokinetic of artemisinin in mice infected by Plasmodium yoelii.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81573682,81102752); 北京市自然科学基金(2112010)
作者简介:张超(1986- ),女,2012年在读硕士研究生。研究方向:中药药物动力学研究。E-mail:13426423780@163.com
通讯作者:王满元(1976- ),博士,副教授,硕士生导师。研究方向:中药药物动力学研究。E-mail: wangmyjun@163.com; 龚慕辛(1968- ),女,博士,教授,博士生导师。研究方向:中药药物动力学研究。E-mail: gongmuxin@126.com
更新日期/Last Update: 2016-04-06