|本期目录/Table of Contents|

[1]严灿,吴丽丽.基于“肾藏精,在志应恐”理论的创伤后应激障碍病机与防治研究思路探讨[J].环球中医药,2016,9(05):578-582.[doi:10.3969/j.issn.1674-1749.2016.05.014]
　YAN Can,WU Li-li..Discussion on pathology and treatment of post-traumatic stress disorder base on the theory of “kidney stores essence and responses to fear” in traditional Chinese medicine[J].,2016,9(05):578-582.[doi:10.3969/j.issn.1674-1749.2016.05.014]
点击复制

基于“肾藏精,在志应恐”理论的创伤后应激障碍病机与防治研究思路探讨()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年05期
页码:
578-582
栏目:
理论探讨
出版日期:
2016-05-06

文章信息/Info

Title:
Discussion on pathology and treatment of post-traumatic stress disorder base on the theory of “kidney stores essence and responses to fear” in traditional Chinese medicine
作者:
严灿; 吴丽丽
510060 广州中医药大学中医基础理论教研室
Author(s):
YAN Can;  WU Li-li.
Department of Basic Theory of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510060, China
关键词:
肾藏精;  在志应恐;  创伤后应激障碍
Keywords:
Kidney storing essence;  Kidney's response to fear;  Post-traumatic stress disorder
分类号:
R277.7
DOI:
10.3969/j.issn.1674-1749.2016.05.014
文献标志码:
A
摘要:
运用中医药理论和治法方药防治创伤后应激障碍(post-traumatic stress disorder,PTSD)的研究虽然刚刚起步,但已显示出良好的应用前景。本文立足于中医“肾藏精,在志应恐”的理论,剖析PTSD的中医病因病机,认为“肾精不足,封藏失职,志气衰败”是PTSD中医病机核心之所在。此外,本文对中医补肾治法方药防治PTSD的现状与药理学基础进行了分析和探讨; 同时,从临床研究、动物模型以及药理学机制研究等方面提出了今后运用补肾治法方药防治PTSD的研究思路。
Abstract:
Although researches on using traditional Chinese medicine theory and formulae in treating and preventing post-traumatic stress disorder(PTSD)has just started, but it has shown a good application prospect. Based on the theory of “kidney stores essence and responses to fear” in traditional Chinese medicine, in this paper, the pathology of post-traumatic stress disorder(PTSD)was analyzed, and showed that the core pathology was “the deficiency of kidney essence, dysfunction in essence storage, which leads to the decline of will”. In addition, the current situation and pharmacological mechanism of “invigorating the kidney” treatment for PTSD were discussed and analyzed, meanwhile, research ideas were proposed from the aspects of clinical research, animal models and pharmacological mechanism and so on.

参考文献/References:

[1] Jordan NN,Hoge CW,Tobler SK,et a1.Mental health impact of 9/11 Pentagon attack:Validation of a rapid assessment tool [J].Am J Prey Med,2004,26(4):284-293.
[2] de Quervain D J,Margraf J. Glucocorticoids for the treatment of posttraumatic stress disorder and phobias:A novel therapeutic approach [J]. Eur J Pharmacol,2008,583(2-3):365-371.
[3] 安献丽,郑希耕.创伤后应激障碍的动物模型及其神经生物学机制[J].心理科学进展,2008,16(3):371-377.
[4] Kozlovsky N,Zohar J,Kaplan Z,et al. Microinfusion of a corti-cotrophin-releasing hormone receptor 1 antisense oligodeoxynu-cleotide into the dorsal hippocampus attenuates stress responses at specific times after stress exposure [J]. Neuroendocrinol,2012,24(3):489-503.
[5] 张黎明,张有志,李云峰.创伤后应激障碍的神经生物学研究进展[J].中国药理学通报,2010,26(6):704-707.
[6] 张萍,王岚,王学义. 创伤后应激障碍生物学机制研究进展[J].中国健康心理学杂志,2010,18(6):748-750.
[7] 张黎明,陈红霞,张有志,等.5-羟色胺与创伤后应激障碍的研究进展[J].中国药理学通报,2010,26(10):1261-1263.
[8] Pakdel R,Rashidy-Pour A. Glucocorticoid-induced impairment of long-term memory retrieval in rats:an interaction with dopamine D2 receptors[J]. Neurobiology of Learning and Memory,2006,85(3):300-306.
[9] Berna Terzio(ˇoverg)lu,Melisa Kaleli,Banu Aydln. Increased Noradrenaline Levels in the Rostral Pons can be Reversed by M1 Antagonist in a Rat Model of Post-traumatic Stress Disorder[J]. Neurochem Res,2013,38(8):1726-1733.
[10] James W. Murrough,Yiyun Huang,Jian Hu,et al. Reduced Amygdala Serotonin Transporter Binding in Posttraumatic Stress Disorder[J]. Biol Psychiatry,2011,70(11):1033-1038.
[11] Qian Li,Tian Luo,Xue Jiang,et al. Anxiolytic effects of 5-HT1A receptors and anxiogenic effects of 5-HT2C receptors in the amygdala of mice[J]. Neuropharmacology,2012,62(1):474-484.
[12] Kaplan GB,Moore KA. The use of cognitive enhancers in animal models of fear extinction[J]. Pharmacol Biochem Behav,2011,99(2):217-228.
[13] Gemma L. Dalton,Dong Chuan Wu,Yu Tian Wang,et al. NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear[J]. Neuropharmacology,2012,62(2):797-806.
[14] Iulia Toth,Monika Dietz,Daniel Peterlik, et al. Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear[J]. Neuropharmacology,2012,62(4):1619-1626.
[15] Matthew J. Davis,Ovidiu D. Iancu,Francine C. Acher,et al. Role of mGluR4 in acquisition of fear learning and memory[J]. Neuropharmacology,2013,66:365-372.
[16] Bazak N,Kozlovsky N,Kaplan Z,et al. Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor [J]. Psychoneuroendocrinology,2009,34(6):844-858.
[17] 苏珊珊,王振,肖泽萍. 创伤后应激障碍相关神经递质和神经肽的研究[J]. 神经疾病与精神卫生,2010,10(5):512-515.
[18] Gilliard Lach,Thereza Christina Monteiro de Lima. Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning:Dissociation between anxiety,locomotion and non-emotional memory behavior[J]. Neurobiology of Learning and Memory,2013,103:26-33.
[19] 李奕祺.论肾藏精起亟[J].福建中医学院学报,2006,16(2):53-54.
[20] 朱伟,黄兆胜.补肾药改善神经内分泌免疫网络老化的研究纂要[J].中医药学刊,2002,20(1):65-66.
[21] 李林,魏海峰,张兰,等.中医“肾生髓,脑为髓海”现代生物学基础探讨[J]. 中国中药杂志,2006,3l(17):1397-1400.
[22] 王米渠,段光周.“恐伤肾”对小鼠 “作强”行为的遗传学研究[J].上海中医药杂志,1997,(7):42-44.
[23] 吴斌,王米渠,王刚.从先天补肾实验谈中医遗传药理研究[J].现代中西医结合杂志,2004,13(10):1259-1260.
[24] 叶菁,邱丽瑛.金匮肾气丸对 “恐伤肾”模型小鼠醛固酮水平的调节作用[J].实用中西医结合临床,2010,10(6):1-3.
[25] 冯晓芬,王玉萍,沈世林.滋补肾精方对“恐伤孕鼠”孕仔数及红细胞免疫功能影响的研究[J].中国中医药科技,2011,18(2):106-107.
[26] 冯晓芬,王玉萍.滋补肾精方对雌性肾虚小鼠内分泌调节功能影响的实验研究[J].中医研究,2010,23(3):14-17.
[27] 袁世宏,王米渠.金匮肾气丸对“恐伤肾”大鼠丘脑、海马c-fos基因表达的影响[J].北京中医药大学学报,2001,24(6):34-36,57.
[28] 张辉,张先庚,高静,等.创伤后压力心理障碍中医治疗研究进展[J].吉林中医药,2015,35(10):1077-1079.
[29] 黎霄羽,姜迎,王小云.补肾法对去卵巢大鼠惊恐反应及海马雌激素受体β表达的影响[J].中华中医药杂志,2013,28(5):1552-1555.
[30] 张鹏,谢磊,罗瑞,等.温补肾阳方对创伤后应激障碍大鼠行为学及血浆17-OHCS、cAMP 影响的研究[J].四川中医,2011,29(9):19-21.
[31] 吴丽丽,严灿,刘书考.肾虚对恐惧记忆形成的影响及补肾方药调节作用的初步研究[J].安徽中医学院学报,2012,31(3):48-52.
[32] 石志霄,石恒录.运用“恐伤肾”理论辨治创伤后应激障碍[J].甘肃中医,2009,22(11):30-31.
[33] 吴韦玮,李凌江.恐惧记忆的再巩固及其干预措施分析[J].中国临床心理学杂志,2012,20(5):649-651.
[34] 张先庚,王红艳. 金匮肾气丸对“恐伤肾”模型仔鼠5-羟色胺水平的调节作用[J].中华中医药杂志,2014,29(2):608-610.
[35] 沈雁,匡调元,张伟荣,等.“恐伤肾”的实验研究[J].中国医药学报,1991,6(1):13-15.
[36] 沈自尹,陈瑜,黄建华,等.以药测证绘制肾虚证两大基因网络调控路线图谱[J].中国中西医结合杂志,2006,26(6):521-525.

相似文献/References:

备注/Memo

备注/Memo:
基金项目: 国家自然科学基金(30873207)
作者简介: 严灿(1970- ),博士,教授,博士生导师。研究方向:情志致病机理与防治。E-mail:yancan999@sina.com
更新日期/Last Update: 2016-05-06