«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第9卷

期数:

2016年05期

页码:

616-620

栏目:

综述

出版日期:

2016-05-06

文章信息/Info

Title:

Research advances intriterpenoids constituents and pharmacological action of Boswellia carterii

作者:

孙妍; 商庆辉

021000 呼伦贝尔市人民医院静脉用药调配室

Author(s):

SUN Yan;  SHANG Qing-hui.

Pharmacy Intravenous Admixture Services, Hulunbeier People's Hospital,Hulunbeier 021000, China

关键词:

乳香;  乳香酸;  三萜化合物;  药理活性

Keywords:

Boswellia carterii Birdw.;  Boswellic acid;  Triterpenoids;  Pharmacological activity

分类号:

R284

DOI:

10.3969/j.issn.1674-1749.2016.05.029

文献标志码:

A

摘要:

乳香为橄榄科植物乳香树或同属植物的胶状树脂,主要活性成分为五环三萜、四环三萜等三萜类化合物。现代药理研究表明乳香有抗炎、抗肿瘤、诱导分化凋亡、抗溃疡、降糖、改善学习记忆等药理活性,在抗炎、抗肿瘤方面药理研究较为深入,不良反应少,有潜在的药用价值。通过查阅文献,对近五年来乳香三萜类成分及其药理作用研究进展进行综述,为乳香的进一步研究提供参考。

Abstract:

In this study, the recent progress in the research of triterpenoids and pharmacological activities of frankincense, the gum resin of Boswellia carterii or the other plants to the same species mainly consisting of chemical constituents, such as pentacyclic triterpenoid and tetracyclic triterpenoid, was reviewed. Investigations demonstrated that resin had the following pharmacological effects: anti-inflammatory, antitumor, inducing differentiation and apoptosis, anti-ulcer, hypoglycemic action, improvement on learning and memory, etc. The results also indicated that fewer adverse reactions and potential medicinal value of this material. The research will provide reference for further research of Boswellia carterii.

参考文献/References:

[1] 陈婷,宿树兰,段金廒,等.乳香没药配伍前后化学成分溶出变化及其对LPS-诱导的巨噬细胞产生NO的影响[J].中国中药杂志,2013,38(2):179-184.
[2] 孙磊,徐纪民,金红宇,等. 乳香基原的本草学、植物学和成分分析研究[J]. 中国中药杂志,2011,36(2):112-116.
[3] Gerbeth K,Hüsch J,Fricker G,et al. In vitro metabolism,permeation,and brain availability of six major boswellic acids from Boswellia serrata gum resins[J]. Fitoterapia,2013,(84):99-106.
[4] Siddiqui M Z. Boswellia serrata,a potential antiinflammatory agent:an overview[J].Indian J Pharmaceut Sci,2011,73(3):255-261.
[5] 王峰,华会明,王淑美.乳香的化学成分[J].中草药,2011,42(7):1293-1296.
[6] Yadav VR,Prasad S,Sung B,et al. Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory,proliferative,invasive and angiogenic biomarkers[J]. Int J Cancer,2011,130(9):2176-2184.
[7] Yuxin Zhang,Zhangchi Ning,Cheng Lu,et al. Triterpenoid resinous metabolites from the genus Boswellia:pharmacological activities and potential species-identifying properties[J]. Chemistry Central Journal,2013,7(1):153.
[8] 常允平,韩英梅,张俊艳. 乳香的化学成分和药理活性研究进展[J]. 现代药物与临床,2012,27(1):52-59.
[9] 王彦改,多蕊蛇菰及乳香的化学成分研究[D].北京:北京协和医学院,2013.
[10] Wang F,Li Z L,Cui H H,et al. Two new triterpenoids from the resin of Boswellia carterii [J]. J Asian Nat Prod Res,2011,13(3):193-197.
[11] Bhushan S,Kumar A,Malik F,et al. A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells[J]. Apoptosis,2007,12(10):1911-1926.
[12] Shen T,Lou HX. Bioactive constituents of myrrh and frankincense,two simultaneously prescribed gum resins in Chinese traditional medicine[J]. Chem Biodivers 2008,5(4):540-553.
[13] Morikawa T,Oominami H,Matsuda H. New terpenoids,olibanumols D-G,from traditional Egyptian medicine olibanum,the gum-resin of Boswellia carterii[J]. J Nat Med,2011,65(1):129-134.
[14] Mathe C,Culioli G,Archier P, et al. Characterization of archaeological frankincense by gas chromatography-mass spectrometry[J].J Chromatogr A,2004,1023(2):277-285.
[15] Büchele B,Zugmaier W,Simmet T.Analysis of pentacyclic triterpenic acids from frankincense gum resins and related phytopharmaceuticals by high-performance liquid chromatography. Identification of lupeolic acid,a novel pentacyclic triterpene[J]. J Chromatogr B,2003,791(1-2):21-30.
[16] Atta-ur-Rahman,Naz H,Fadimatou,et al. Bioactive constituents from Boswellia papyrifera[J]. J Nat Prod,2005,68(2):189-193.
[17] Culioli G,Mathe C,Archier P,et al. A lupane triterpene from frankincense(Boswellia sp. Burseraceae)[J]. Phytochemistry,2003,62(4):537-541.
[18] Verhoff M,Seitz S,Northoff H,et al. A novel C(28)hydroxylated lupeolic acid suppresses the biosynthesis of eicosanoids through inhibition of cytosolic phospholipase A2[J]. Biochem Pharmacol,2012,84(5):681-691.
[19] Banno N,Akihisa T,Yasukawa K,et al. Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri[J]. J Ethnopharmacol,2006,107(2):249-253.
[20] 任晋,苏亚伦.乳香的化学成分研究[C]//第十二届全国青年药学工作者最新科研成果交流会论文集,2014:297-299.
[21] Estrada AC1,Syrovets T,Pitterle K,et al. Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells[J]. Mol Pharmacol,2010,77(3):378-387.
[22] Aksamija A,Mathe C,Vieillescazes C. Liquid chromatography of triterpenic resins after derivatization with dansyl chloride[J]. Liq Chrom Relat Tech,2012,35(9):1222-1237.
[23] 张玉柱.中药乳香的化学成分及生物活性研究[D]. 上海:东华大学,2014.
[24] Catanzaro D,Rancan S,Orso G,et al. Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage[J]. PLoS One,2015,10(5):1-15.
[25] 刘慧萍.天然化合物Riccardin D和乳香酸APC^Min+小鼠肠微腺瘤的化学预防作用研究[D]. 济南:山东大学,2012.
[26] Liang Y H,Li P,Zhao J X,et al. Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1 [J]. Chin J Integr Med,2010,8(11):1060-1069.
[27] 刘绍军,刘丽娜.3-乙酰基-11-酮- β-乳香酸的抗炎作用及其衍生物的化学修饰[J].中国当代医药,2011,18(16):15-17.
[28] 陈婷,宿树兰,段金廒,等.乳香没药配伍前后化学成分溶出变化及其对LPS-诱导的巨噬细胞产生NO的影响[J].中国中药杂志,2013.38(2):179-184.
[29] 田中心,李松武,张振凌.乳香炮制前后抗炎作用比较及其机制初探[J].光明中医,2011,26(4):693-694.
[30] Henkel A,Kather N,Moench B,et al. Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct moleculat interference[J]. Biochemical Pharmacology,2012,83(1):115-121.
[31] Siemoneit U,Koeberle A,Rossi A,et al. Inhibition of microsomal Prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense [J]. British Journal of Pharmacology,2011,162(1):147-162.
[32] 刘淼.乳香树脂提取物对日本吸血虫感染小鼠肝脏肉芽肿和纤维化的抑制作用及其机制[D].合肥:安徽医科大学,2013.
[33] Abdel T M,Werz O,Schubert Z M. Boswellia serrata,an overall assessment of in vitro,preclinical,pharmacokinetic and clinical data [J]. Clinical Pharmacokinetics,2011,50(6):349-369.
[34] 张勇.α-乳香酸抗急性髓细胞白血病血管新生的实验研究[D].长沙:中南大学,2013.
[35] Agrawal SS,Saraswati S,Mathur R,et al. Antitumor properties of boswellic acid against Ehrlich ascites cells bearing mouse [J]. Food Chem Toxicol,2011,49(9):1924-1934.
[36] Park B,Sung B,Yadav V R,et al. Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the down regulation of CXCR4 chemokine receptor expression [J].Int J Cancer,2011,129(1):23-33.
[37] Park B,Prasad S,Yadav V. Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets [J]. PLoS One,2011,6(10):1-11.
[38] 王睿齐.乳香酸和阿司匹林对APC ^Min/+小鼠肠腺瘤化学预防作用的比较研究 [D].济南:山东大学,2014.
[39] 袁小瑜,李跃辉,齐振华,等.乙酰基-11-酮基-β乳香酸对急性髓系白血病细胞HL-60细胞增殖、凋亡和细胞周期的影响[J].中国实验血液学杂志,2010,18(6):1440-1444.
[40] Suhail MM,Wu WJ. Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells[J]. Complementary and Alternative Medicine,2011,(11):129-132.
[41] 何蕊伶,张娟娟,缪世坤,等. 11-羰基-β-香酸在体外对人结肠癌抑制作用的研究[J].中药药理与临床,2010,26(2):19-21.
[42] Khan MA,Singh M,Khan MS,et al. Caspase mediated synergistic effect of Boswellia serrata extract in combination with doxorubicin against human hepatocellular carcinoma[J].Biomed Res Int,2014,(2014):294143.
[43] Zhang YS,Xie JZ,Zhong JL,et al. Acetyl-11-keto-β-boswellic acid(AKBA)inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway[J].Biochim Biophys Acta, 2013,1830,(6):3604-3615.
[44] 梅武轩,曾常春.乳香提取物对大鼠乙酸胃溃疡愈合质量的影响研究 [J].现代中西医结合杂志,2012,21(5):478-486.
[45] 柏景坪,王红健,蓝爱仙.乳香酸治疗口腔溃疡的动物实验研究[J].北京口腔医学,2012,20(6):318-321.
[46] Ruchita V Kumar,Vivek Ranjan Sinha. A Novel Synergistic Galactomannan-Based Unit Dosage Form for Sustained Release of Acarbose[J].AAPS PharmSciTech,2012,13(1):262-275.
[47] Shehata A M,Quintanilla F L,Bettio S. Prevention of multiple low-dose streptozotocin(MLD-STZ)diabetes in mice by an extract from gum resin of Boswellia serrata(BE)[J]. Phytomedicine,2011,18(12):1037-1044.
[48] Karima O,Riazi G,Yousefi R,et al. The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching(an in vitro study)[J]. Neurol Sci,2010,31(3):315-320.
[49] Hosseini M,Hadjzadeh M A,Derakhshan M,et al. The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in morris water maze [J]. Arch Pharm Res,2010,33(3):463-468.
[50] 王宏林.一种抗牛皮癣纯天然新药(11-羰基-β- 乙酰乳香酸): 中国,101724004A[P].2010-06-09. http://user.aptchina.com/down/zhuanli/4290168/download.html.
[51] Mothana RAA,Hasson SS,Schultze W,et al. Phytochemical composition and in vitro antimicrobial and antioxidant activities of essential oils of three endemic SoqotraenBoswellia species.[J]. Food Chem,2011,126:1149-1154.
[52] Calzavara-Pinton P,Zane C,Facchinetti E,et al. Topical boswellic acids for treatment of photoaged skin [J]. Dermatol Ther,2010,23(Suppl 1):28-32.
[53] 于文会.乳香提取物对大鼠皮肤周围神经损伤修复的影响[D].哈尔滨:东北农业大学,2014.
[54] 张业奇,邓鲲华,杨怡,等.乳香精油抗抑郁作用的研究[J].天然产物研究与开发,2015,(27):31-34.
[55] Mallik A,Goupale D,Dhongade H,et al. Evaluation of Boswellia serrata oleo gum resin for wound healing activity [J]. Pharmacia Lettre,2010,2(1):457-463.

相似文献/References:

备注/Memo

备注/Memo:

作者简介: 孙妍(1988- ),女,硕士,药师。研究方向:天然药物化学。E-mail:sunyan7773@126.com
通讯作者: 商庆辉(1974- ),硕士,副主任临床药师。研究方向:临床药理学。E-mail:shangqh_0126@eyou.com

常用功能

更新日期/Last Update: 2016-05-06