|本期目录/Table of Contents|

[1]滕会会,杜守颖,白洁,等.基于中药指纹图谱结合化学模式识别的清开灵软/硬胶囊的成分分析[J].环球中医药,2016,9(06):671-677.[doi:10.3969/j.issn.1674-1749.2016.06.007]
　TENG Hui-hui,DU Shou-ying,BAI Jie,et al.Composition analysis of Qingkailing hard and soft capsule based on fingerprint combined with chemical pattern recognition[J].,2016,9(06):671-677.[doi:10.3969/j.issn.1674-1749.2016.06.007]
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基于中药指纹图谱结合化学模式识别的清开灵软/硬胶囊的成分分析()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年06期
页码:
671-677
栏目:
论著
出版日期:
2016-06-06

文章信息/Info

Title:
Composition analysis of Qingkailing hard and soft capsule based on fingerprint combined with chemical pattern recognition
作者:
滕会会; 杜守颖; 白洁; 陆洋; 李鹏跃; 张晴; 杜秋; 王振; 田志浩
100102 北京中医药大学中药学院[滕会会(硕士研究生)、杜守颖、白洁、陆洋、李鹏跃、张晴(硕士研究生)、杜秋(硕士研究生)、王振(硕士研究生)、田志浩(博士研究生)]
Author(s):
TENG Hui-hui;  DU Shou-ying;  BAI Jie; et al.
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China
关键词:
化学模式识别;  HPLC指纹图谱;  清开灵软/硬胶囊;  含量测定
Keywords:
Chemical pattern recognition;  HPLC fingerprint;  Qingkailing hard and soft capsule;  Content determination
分类号:
R284
DOI:
10.3969/j.issn.1674-1749.2016.06.007
文献标志码:
A
摘要:
目的 对清开灵软/硬胶囊化学成分进行全面整体分析。方法 采用HPLC-DAD建立5种指标性成分含量测定及指纹图谱方法; 通过模式识别技术进行整体分析,并寻找出两者差异最大的化学成分。结果 两者胆酸、猪去氧胆酸和黄芩苷含量差异较小,绿原酸和栀子苷含量差异较大; PCA分析得到59个化学成分浓度在软胶囊中高,40个化学成分浓度在硬胶囊中高,PLS分析得到对两者差异性贡献度最大的16个成分。结论 清开灵软/硬胶囊化学成分存在明显的差异; 多成分定量结合指纹图谱与化学模式识别技术可用于化学成分的全面分析。
Abstract:
Objective To realize the comprehensive overall analysis on the Qingkailing hard and soft capsule chemical composition. Methods HPLC-DAD method was used to establish five indexes determination of component content and fingerprint method. Chemical pattern recognition technology was used for the overall analysis, and the biggest difference in chemical composition between hard and soft capsule was found out. Results The content of baicalin and hyodeoxycholic acid and cholic acid had no significant differences, but obvious differences were found in contents between chlorogenic acid and geniposide. PCA analysis got 59 chemical components concentration highly included in soft capsule, 40 high chemical concentration in hard capsule. PLS analysis obtained 16 largest differences chemical compositions. Conclusion Qingkailing Soft/hard capsules chemical composition existed obvious differences. Multicomponent quantitative methods combined with fingerprint and chemical pattern recognition technology can be used for the comprehensive analysis of chemical composition.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目: 北京市科技新星计划(xx2015A048); 证候与方剂基础研究北京市重点实验室(BZ0102)
作者简介: 滕会会(1988- ),女,2013级在读硕士研究生。研究方向:中药新剂型与新技术研究。E-mail:h15810377850@163.com
通讯作者: 杜守颖(1960- ),女,博士,教授,博士生导师。研究方向:中药新剂型与制剂关键技术。E-mail:dushouying@263.net
更新日期/Last Update: 2016-06-06