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[1]张玲玲 倪健 杜雪莹 张欣 张娟 王海涛 杨春静 付京 张淼 郝晓凤 谢立科 曲昌海.当归、薄荷挥发油提取及包合工艺研究[J].环球中医药,2017,10(07):708-712.[doi:10.3969/j.issn.1674-1749.2017.07.007]
　ZHANG Lingling,NI Jian,DU Xueying,et al.Study on the extraction and inclusion process of volatile oil from angelicae sinensis radix and mentha canadensis[J].,2017,10(07):708-712.[doi:10.3969/j.issn.1674-1749.2017.07.007]
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当归、薄荷挥发油提取及包合工艺研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年07期
页码:
708-712
栏目:
论著
出版日期:
2017-07-06

文章信息/Info

Title:
Study on the extraction and inclusion process of volatile oil from angelicae sinensis radix and mentha canadensis
作者:
张玲玲 倪健 杜雪莹 张欣 张娟 王海涛 杨春静 付京 张淼 郝晓凤 谢立科 曲昌海
100102 北京中医药大学中药学院[张玲玲(硕士研究生)、倪健、杜雪莹(硕士研究生)、张欣(硕士研究生)、张娟(硕士研究生)、王海涛(硕士研究生)、杨春静(博士研究生)、付京(博士研究生)、张淼(博士研究生)、曲昌海]; 中国医学科学院眼科医院内障眼病2科(郝晓凤、谢立科)
Author(s):
ZHANG Lingling;  NI Jian;  DU Xueying; et al.
Institute of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100102,China
关键词:
当归;  薄荷;  挥发油;  提取工艺;  包合工艺;  β-环糊精
Keywords:
Angelicae sinensis radix;  Mentha canadensis;  Volatile oil;  Extraction technology;  Inclusion technology;  β-cyclodextrin
分类号:
R284.2
DOI:
10.3969/j.issn.1674-1749.2017.07.007
文献标志码:
A
摘要:
目的 优选当归、薄荷挥发油的提取及β-环糊精包合工艺。 方法 采用水蒸气蒸馏法进行提取,以加水倍量、蒸馏时间为考察因素,以挥发油体积为评价指标。包合工艺以温度、搅拌时间、挥发油与β-环糊精和水的配比(mL:g:mL)为考察因素,以挥发油包合率和包合物产量为评价指标,采用饱和水溶液法,以正交试验优选包合工艺。采用X射线衍射法和显微镜法对包合物进行验证。 结果 优选的提取工艺为当归、薄荷加8倍量水,提取6小时; 包合工艺为温度30℃,搅拌3小时,挥发油:β-CD:水=1:6:60(mL:g:mL)。验证结果显示包合物形成。结论 所选工艺合理、可行,可用于当归、薄荷中挥发油的提取及挥发油与β-环糊精的包合。
Abstract:
Objective To optimize the extraction process of essential oil from Angelica sinensis and Mentha Canadensis and the inclusion process of beta cyclodextrin. Methods Steam distillation was used to extract, the amount of water and distillation time were taken as the research factors, and the volume of volatile oil was used as the evaluation index. Temperature, mixing time, the ratio of volatile oil, beta cyclodextrin and water(mL:g:mL)were taken as the research factors of inclusion process. The inclusion rate and inclusion yield of volatile oil were used as evaluation indexes, and saturated water solution method was used, the inclusion process was optimized by orthogonal test. The inclusion complexes were verified by X ray diffraction and microscopy. Results The optimized extraction conditions were 8 times amount of water, extracting for 6 hours. The optimized inclusion conditions were the temperature is 30℃, stirring for 3 hours, the volatile oil:beta -CD: water =1:6:60(mL:g:mL). Validation results showed inclusion complexes formed. Conclusion The process is reasonable and feasible, and can be used for the extraction of volatile oil from Angelica sinensis and Mentha Canadensis,, and be used for the inclusion of volatile oil and beta cyclodextrin.

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备注/Memo

备注/Memo:
基金项目: 北京市科学技术委员会“十病十药”专项基金(Z141100002214001)
作者简介: 张玲玲(1990- ),女,2014级在读硕士研究生。研究方向:中药新剂型与新技术。E-mail:zjiuling@163.com
通信作者: 曲昌海(1980- ),博士,助理研究员。研究方向:药物制剂新技术及递药系统研究。E-mail:quchanghai@bucm.edu.cn
更新日期/Last Update: 2017-07-06