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[1]卢迪 赵丕文 赵笛 杨阳 石丹宁.丹参及其有效成分治疗乳腺癌作用机制的研究进展[J].环球中医药,2017,10(09):1046-1050.[doi:10.3969/j.issn.1674-1749.2017.09.036]
　LU Di,ZHAO Piwen,ZHAO Di,et al.Research progress on the mechanism of salvia miltiorrhiza and its active ingredients in the treatment of breast cancer[J].,2017,10(09):1046-1050.[doi:10.3969/j.issn.1674-1749.2017.09.036]
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丹参及其有效成分治疗乳腺癌作用机制的研究进展()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第10卷
期数:
2017年09期
页码:
1046-1050
栏目:
综述
出版日期:
2017-09-06

文章信息/Info

Title:
Research progress on the mechanism of salvia miltiorrhiza and its active ingredients in the treatment of breast cancer
作者:
卢迪 赵丕文 赵笛 杨阳 石丹宁
100029 北京中医药大学生命科学学院[卢迪(硕士研究生)、赵丕文、赵笛(硕士研究生)、杨阳(硕士研究生)、石丹宁(硕士研究生)]
Author(s):
LU Di; ZHAO Piwen; ZHAO Di; et al.
School of Life Science,Beijing University of Chinese Medicine,Beijing 100029,China
关键词:
丹参;  细胞增殖;  细胞凋亡;  肿瘤转移;  耐药逆转;  临床应用
Keywords:
Salvia miltiorrhiza;  Cell proliferation;  Cell apoptosis;  Tumor metastasis;  Reversal of drug resistance;  Clinical application
分类号:
R285
DOI:
10.3969/j.issn.1674-1749.2017.09.036
文献标志码:
A
摘要:
丹参中含有多种抗乳腺癌的有效成分,其治疗乳腺癌的作用机理成为近年的研究热点。近年来研究表明,丹参有效成分可多靶点、多途径抑制乳腺癌细胞生长增殖,促进细胞凋亡,其作用机制与增殖、凋亡信号传导通路密切相关; 丹参在抑制肿瘤迁移和耐药逆转方面也能发挥有效作用。在临床应用中,丹参在改善乳腺癌患者的临床症状和术后并发症、减轻化疗带来的不良反应等方面有显著疗效。
Abstract:
A variety of components in salvia miltiorrhiza are effective in treating breast cancer and its mechanism has become a hot research topic in recent years. Research in recent years showed that effective components in salvia miltiorrhiza could inhibit growth and proliferation of breast cancer cells and promote cell apoptosis by various ways. The mechanism of action is closely related to the signal pathways of cell proliferation and apoptosis. Salvia miltiorrhiza also played an effective role in inhibiting tumor metastasis and reversal of drug resistance. In clinical application, salvia miltiorrhiza has great advantages in improving clinical symptoms, postoperative complications and adverse reactions after chemotherapy of breast cancer patients.

参考文献/References:

[1] Chen WQ, Zheng RS, Baade PD, et al. Cancer Statistics in China 2015[J]. CA Cancer J Clin,2016,66(2):115-132.
[2] 赵丕文,牛建昭,王继峰,等. 6种中药活性成分植物雌激素作用的比较研究[J].中国药学杂志,2007,42(24):1853-1855.
[3] 赵丕文,牛建昭,王继峰,等. 丹参酮ⅡA抗乳腺癌细胞增殖作用研究[J].中国药理学通报,2010,26(7):903-906.
[4] 臧金凤.ER介导丹参酮ⅡA抗妇科肿瘤作用机制的研究[D].北京:北京中医药大学,2016.
[5] Binai NA, Damert A, Carra G, et al. Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells[J]. Int J Cancer,2010,127(1):55-66.
[6] 王健,徐杰,安雪青,等.雌激素活化GPER 介导的IL-6/STAT3通路促进乳腺癌细胞SKBR-3增殖作用[J]. 第三军医大学学报,2015,2(3):340-345.
[7] 易长胜,廖坤,余良忠,等. 丹参素对乳腺癌MCF-7细胞株增殖影响及其分子机制[J]. 福建医药杂志, 2015,37(5):56-58.
[8] Vogelstein B, Lane D, Levine AJ, et al. Surfing the p53 network[J].Nature,2000,(408):307-310.
[9] 刘永惠,郭少贤,常靖,等.丹参酮对血瘀证乳腺癌p53基因、mdm2基因表达的影响[J]. 陕西中医,2011,32(12):1666-1667.
[10] 张欣,张蒲蓉,陈洁,等.丹参酮ⅡA对乳腺癌抑制作用的体内实验研究[J]. 四川大学学报(医学版),2010,41(1):62 -67.
[11] Cheng H, Ma B, Jiang R, et al. Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk:an updated meta-analysis[J]. Mol Biol Rep,2012,39(9):9265.
[12] 张梦怡,陈鹰,樊荣丹,等. 抑癌基因p53、癌基因MDM2与乳腺癌关系的研究进展[J].中国药房,2014,25(29):2770.
[13] 周瑞芳. PE相关中药黄芪、丹参对人乳腺癌MCF-7、MDA-MB-231细胞增殖凋亡的影响[D].广州:广州中医药大学,2008.
[14] Yan MY, Chien SY, Kuo SJ,et al. TanshinoneⅡA inhibits BT-20 human breast cancer cell proliferation through increasing caspase12, GADD153 and phosphor-p38 protein expression[J].Int J Mol Med, 2012,29(5):855-863.
[15] Cmmero A,Blanoc-Aparicio C,Renner O,et al.The PTEN/PI3K/Akt signaling pathway in cancer, therapeutic implications[J]. Curr Cancer Drug Targets, 2008,8(3):187-198.
[16] 王丽.丹参酮Ⅰ对人乳腺癌细胞的抑制作用及对PI3K/Akt/mT0R信号通路的影响[D].南京:南京中医药大学,2014.
[17] 刘静,赵浩亮.1,25二羟维生素D3与5-氟尿嘧啶对乳腺癌细胞生长及凋亡的影响[J].中华实验外科杂志,2005,22(5):535-537.
[18] 翟凤钰, 李修炜,漆起贵,等.丹参酮ⅡA联合5-Fu诱导人乳腺癌细胞系MCF-7凋亡的影响[J].军医进修学院学报,2012,33(6):653-655.
[19] 高丽,徐长亮,何赟绵,等.丹参酮ⅡA对乳腺癌细胞株MDA-MB-231体外血管生成拟态的抑制作用[J].药学与临床研究,2011,19(4):315-317.
[20] Xu CL,Xi T.Anti-migration and anti-angiogenic effectsoftanshinoneⅡA on breast cancer cell MDA-MB-435[J].J China Pharm Univ,2009,40(6): 565-570.
[21] 朱智杰,刘兆国,周梁,等.隐丹参酮对人乳腺癌细胞MDA-MB-231转移的影响及其分子机制[J].中国实验方剂学志,2014,20(11):161-164.
[22] 王跃华,郭章雄,朱志斌,等.丹参酮ⅡA 抑制乳腺癌细胞转移的机制[J].黑龙江医学,2015,39(11):1209-1212.
[23] 翁时秋,王小云,丁志云,等.丹参酮ⅡA 抑制乳腺癌转移相关基因GEP100表达的实验研究[J]. 江苏中医药,2011,43(12):80-81.
[24] 李晓婷,张晓鹏.细胞自噬在肿瘤发生、转移与治疗中的作用[J].当代医学,2011,17(9):13-14.
[25] 全军利,贺文兴,吴斯敏,等.隐丹参酮对乳腺癌MDA-MB-231 细胞自噬和侵袭迁移的影响[J].广西医科大学学报,2015,32(1):23-26.
[26] Pan TL,Wang PW,Huang YC,et al.Proteomic analysis reveals tanshinoneⅡA enhances apoptosis of advanced cervix carcinoma CaSki cells through mitochondria in trinsic and endoplasmic reticulum stress pathways[J]. Proteomics, 2013,(13): 3411 -3423.
[27] 敬静,郑鸿,王静,等.丹参酮ⅡA对人ER阴性乳腺癌细胞的生长抑制和多耐药逆转作用[J]. 四川大学学报(医学版),2007,38(3):391-395.
[28] FuP, DuF, Chen W, et al.TanshinoneⅡA blocks epithelial mesenchymal transition through HIF-1α downregulation, reversing hypoxia-induced chemotherapy resistance in breast cancer cell lines[J]. Oncol Rep, 2014, 31(6): 2561 -2568.
[29] Jiao JW, Wen F. TanshinoneⅡA acts via p38 MAPK to induce apoptosis and the down-regulation of ERCC1 and long-resistance protein in cisplatin-resistant ovarian cancer cells[J]. Oncol Rep, 2011, 25(1):781.
[30] 潘登,陈可和.丹参酮ⅡA逆转多药耐药的体外效应研究[J].中国药房,2015,26(25):3488-3489.
[31] 张伟伟.丹参素对黑色素瘤细胞粘附和侵袭生物学行为的影响及其机理研究[D].南京:南京中医药大学,2010.
[32] 肖锋,肖茂良,唐友斌,等.复方丹参滴丸预防左侧乳腺癌患者放射性心脏病的临床观察[J].中外健康文摘,2014,(20):140.
[33] 宋玮,甄林林.多西他赛联合中药丹参治疗乳腺癌临床观察[J].辽宁中医杂志,2014,41(8):1703-1704.
[34] 张敬涛.黄芪多糖合丹参酮对40例中晚期乳腺癌化疗的影响[J].中国药物经济学,2013,(5):293-298.
[35] 吴祖培,罗金珠,陈宇宁,等.丹参注射剂预防老年乳癌术后皮瓣坏死的研究[J].今日医药,2009,19(10):38-40.

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金(81673764)
作者简介: 卢迪(1992- ),女,2015级在读硕士研究生。研究方向:中药治疗妇科肿瘤的作用机制。E-mail:ludi324@163.com
通信作者: 赵丕文(1967- ),女,博士,教授,硕士生导师。研究方向:妇科常用中药的作用机制。E-mail:pwzhao@263.net
更新日期/Last Update: 2017-09-06