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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第10卷

期数:

2017年11期

页码:

1242-1247

栏目:

数据挖掘

出版日期:

2017-11-06

文章信息/Info

Title:

Multivariate analysis of TCM syndromes elements of endometriosis

作者:

余燚薇; 赵瑞华; 张润顺; 史云; 王小云; 刘雁峰; 王必勤; 梁瑞宁; 李伟莉; 宋殿荣

100053 北京,中国中医科学院广安门医院妇科(余燚薇、赵瑞华),名老中医研究室(张润顺); 广州中医药大学第一附属医院妇科(史云); 广东省中医院妇科(王小云); 北京中医药大学东直门医院妇科(刘雁峰、王必勤); 江西省中医院妇科(梁瑞宁); 安徽省中医院妇科(李伟莉); 天津中医药大学附属第二医院妇科(宋殿荣)

Author(s):

YU Yiwei;  ZHAO Ruihua;  ZHANG Runshun;  et al.

Department of gynecology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053,China

关键词:

子宫内膜异位症;  证候要素;  横断面研究;  气滞血瘀证

Keywords:

Endometriosis;  Syndrome elements;  Cross-sectional study;  The syndrome of qi stagnation and blood stasis

分类号:

R711.71

DOI:

10.3969/j.issn.1674-1749.2017.11.012

文献标志码:

A

摘要:

目的 探索子宫内膜异位症的中医证候要素分布规律。方法 在多中心、横断面临床流行病学的基础上采集450例子宫内膜异位症患者临床资料,建立数据库,采用聚类分析和因子分析方法探讨其证候要素组成及分布规律。结果 经指标聚类分析方法,将82个症状条目聚为28类,经因子分析,得到24个公因子,初步提取出病位证素4个:胞宫、肝、肾、脾; 病性证素10个:气滞、瘀血、寒、热、湿、痰、气虚、血虚、阳虚、阴虚。经动态样品聚类分析发现聚为6类时最符合临床,结合专业知识进行分析,第1～6类分别命名为寒凝血瘀证、湿热瘀阻证、气滞血瘀证、气虚血瘀证、肾虚血瘀证、痰瘀互结证,其中气滞血瘀证所占比例最大(36.2%)。结论 子宫内膜异位症的病位在胞宫,与肝、肾、脾相关,病性虚实夹杂,主要证素为气滞、瘀血、寒、热、湿、痰、气虚、血虚、阳虚、阴虚,中医证型以气滞血瘀证为主。

Abstract:

Objective To explore the distribution regularity of TCM syndrome elements in endometriosis. Methods Based on the multicenter and cross-sectional clinical epidemiological investigation, the clinical materials of 450 cases of endometriosis were collected, and the database was establish. Clustering analysis and factor analysis were used to explore composition and distribution law of TCM syndromes elements in endometriosis. Results By means of index clustering analysis method,82 symptoms was clustered into 28 categories, and 24 common factors were obtained by factor analysis, There were 4 syndrome elements of disease locations: uterus, liver, kidney, spleen. The nature syndrome element were: qi stagnation, blood stasis, cold pathogen, heat pathogen, dampness pathogen, phlegm, qi deficiency, blood deficiency, yang deficiency, yin deficiency. Cluster analysis of dynamic samples showed that the 6 classes were the most suitable for clinical use, and analyzed with professional knowledge, the category 1～6 was named as syndrome of cold coagulation and blood stasis, syndrome of stagnant dampness-heat, syndrome of qi-stagnancy and blood stasis, syndrome of blood stasis due to qi deficiency, syndrome of blood stasis due to qi deficiency, syndrome of kidney deficiency and blood stasis, syndrome of intermin-gled phlegm and blood stasis. Syndrome of qi stagnation and blood stasis was the most common symptoms, the proportion was 36.2%. Conclusion The disease location of endometriosis is in uterus, and it is related to liver, kidney and spleen. The nature of disease is intermingled deficiency and excess, the main syndrome elements were: qi stagnation,blood stasis, cold pathogen, heat pathogen, dampness pathogen, phlegm, qi deficiency, blood deficiency, yang deficiency, yin deficiency. Qi stagnation and blood stasis is the most common symptoms.

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备注/Memo

备注/Memo:

基金项目: 国家“十一·五”科技支撑计划(2006BA104A17); 中国中医科学院广安门医院所级课题(2015s326)
作者简介: 余燚薇(1988- ),女,硕士,住院医师。研究方向:中医药治疗子宫内膜异位症的临床研究。E-mail:yiwei.0707@163.com
通信作者: 赵瑞华(1959- ),女,博士,主任医师。研究方向:子宫内膜异位症及术后复发的临床和基础研究。E-mail:rhzh801@126.com

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更新日期/Last Update: 2017-11-06