|本期目录/Table of Contents|

[1]金泉克,许建华,肖海娟,等.肠胃清煎剂对裸鼠大肠癌皮下移植瘤奥沙利铂治疗的增效作用[J].环球中医药,2012,5(03):175-0.
　JIN Quan ke,XU Jian hua,XIAO Hai juan,et al.Changweiqing decoction increase the effects of oxaliplatin in human colorectal cancer cell line HCT 116/LOHP yumor xenograft mice[J].,2012,5(03):175-0.
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肠胃清煎剂对裸鼠大肠癌皮下移植瘤奥沙利铂治疗的增效作用()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第5卷
期数:
2012年03期
页码:
175-0
栏目:
论著
出版日期:
2012-03-06

文章信息/Info

Title:
Changweiqing decoction increase the effects of oxaliplatin in human colorectal cancer cell line HCT 116/LOHP yumor xenograft mice
作者:
金泉克; 许建华; 肖海娟; 陆海; 余文燕; 王国娟; 孙珏; 范忠泽;
Author(s):
JIN Quanke;  XU Jianhua;  XIAO Haijuan;  et al.
Department of oncology, Shanghai Putuo Hospital Affiliated to Shanghai University of TCM. Shanghai 200062, China
关键词:
肠胃清煎剂;  中医药;  移植瘤;  奥沙利铂;  耐药;  结肠癌
Keywords:
Changweiqing Decoction; Chinese medicine; Xenograft; Oxaliplatin; Multidrug resistance; Colon cancer
分类号:
R733
DOI:
-
文献标志码:
A
摘要:
目的探讨肠胃清煎剂对奥沙利铂(L-OHP)治疗结肠癌耐药细胞皮下移植瘤的增效作用。方法采用皮下接种构建结肠癌耐药细胞HCT116/L-OHP及敏感细胞HCT116异位瘤模型,运用中药复方肠胃清煎剂及1/2最大耐受剂量的L-OHP干预后,观察L-OHP对移植瘤体积及裸鼠体重的影响、中药复方作用后L-OHP治疗效果的变化。结果肠胃清煎剂及肠胃清煎剂联合L-OHP组荷瘤鼠体重减轻影响均少于单纯L-OHP组(P<0.01)。肠胃清煎剂低、高剂量联合L-OHP组肿瘤体积分别为53.75%、48.32%,同单纯中药或L-OHP比较,减小明显(P<0.01)。结论肠胃清煎剂具有一定抑制肿瘤生长的能力,在联合化疗药物作用下,其抑制效果明显,在有效治疗剂量中,与肠胃清煎剂剂量成正比。
Abstract:
ObjectiveTo investigate the effect of Changweiqing Decoction（CWQ） formula on the growth of human colorectal carcinoma cell line HCT 116 and HCT 116/LOHP transplanted subcutaneously in nude mice. MethodsNude mouse model of human colorectal carcinoma by subcutaneous transplantation of HCT 116 and HCT/LOHP cell line was reproduced. A total of 50 mice were divided into 5 groups：control group and CWQ group（oral administration of CWQ at 50 mg/ kg/ d）、LOHP(1/2 TMD)、high does CWQ+LOHP and low does CWQ+LOHP. The growth of the subcutaneously transplanted tumor and changes in mouse body weight in each group after treatment were observed three weeks. ResultsThe decrease of weight in CWQ+LOHP group was less than LOHP group; the tumor volume in lower dose CWQ+LOHP group and higher dose CWQ+LOHP group were 53.75%、48.32%, respectively, which were significantly smaller than that of CWQ or LOHP groups(P<0.01). Conclusion CWQ has inhibitory effect on the growth of human colorectal carcinoma transplanted subcutaneously in nude mice, especially on HCT 116/LOHP transplanted subcutaneously nude mice. The results provide the evidence of CWQ combination with LOHP for the prevention and treatment of human colorectal carcinoma.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（30873404，81073105）；上海市科委中药现代化专项（09dZ1975500，10dZ1975500）；上海市普陀区卫生系统自主创新科研基金
作者单位：200062上海中医药大学附属普陀医院［金泉克（博士研究生）、肖海娟（博士研究生）、余文燕（博士研究生）、王国娟（博士研究生）］；上海市普陀区中心医院肿瘤科［许建华、陆海、孙珏、范忠泽、金泉克（博士研究生）、肖海娟（博士研究生）、余文燕（博士研究生）、王国娟（博士研究生）］
作者简介：金泉克（1980- ），2009级在读博士研究生。研究方向：中药防治恶性肿瘤的临床与实验研究。Email：keerkin@yahoo.com.cn
通讯作者：范忠泽（1950- ），硕士，教授，主任医师。研究方向：中药防治恶性肿瘤的临床与实验研究。Email：fanzhongze@citiz.net
更新日期/Last Update: 1900-01-01