|本期目录/Table of Contents|

[1]张文洁,徐雅.己酮可可碱对心肌梗死后抑郁大鼠的行为学 特征变化的作用研究[J].环球中医药,2015,8(05):531-534.[doi:10.3969/j.issn.16741749.2015.05.005]
　ZHANG Wen jie,XU Ya..Effect of pentoxifyline on behavioral characteristics changes in depression rats after myocardial infarction[J].,2015,8(05):531-534.[doi:10.3969/j.issn.16741749.2015.05.005]
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己酮可可碱对心肌梗死后抑郁大鼠的行为学 特征变化的作用研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年05期
页码:
531-534
栏目:
论著
出版日期:
2015-05-06

文章信息/Info

Title:
Effect of pentoxifyline on behavioral characteristics changes in depression rats after myocardial infarction
作者:
张文洁; 徐雅
100029 北京中医药大学基础医学院\[张文洁（硕士研究生），徐雅\]
Author(s):
ZHANG Wenjie;  XU Ya.
School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
心肌梗死; 己酮可可碱; 抑郁; 炎症反应
Keywords:
Myocardial infarction;  Pentoxifylline;  Depression;  Inflammation
分类号:
R5422+2
DOI:
10.3969/j.issn.16741749.2015.05.005
文献标志码:
A
摘要:
目的研究心肌梗死大鼠使用前炎症细胞抑制剂己酮可可碱后行为学特征的变化，为研究心肌梗死后抑郁的发生机制及心脑与神志的关系提供实验依据。方法采用结扎大鼠心脏左冠状动脉前降支的方法制作心肌梗死大鼠模型，采用ELISA试剂盒检测血浆中肿瘤坏死因子α的浓度；采用旷场实验和强迫游泳实验观察心肌梗死大鼠使用己酮可可碱后的行为学变化特征。结果大鼠心肌梗死后4周，与模型组相比，己酮可可碱组的肿瘤坏死因子α水平明显降低，活动总路程、总时间、直立次数、爬壁次数均明显增多，不动时间明显减少（P<005）。结论己酮可可碱可以阻断心肌梗死后所诱导的炎症反应；心肌梗死后大鼠出现活动度下降，对新鲜环境的好奇程度下降及行为绝望等行为学改变。提示心肌梗死后大鼠存在抑郁症状，心与神志在病理上存在一定联系。使用己酮可可碱后大鼠的抑郁症状得到一定程度的缓解，提示急性心肌梗死后抑郁与炎症反应相关。
Abstract:
ObjectiveTo investigate the behavior changes of rats after acute myocardial infarction after using the proinflammatory cytokine synthesis blocker  PTX (pentoxifylline), so as to provide the experimental basis for the treatment and further study on the mechanism of depression after acute myocardial infarction. MethodsThe rats were given thoracotomy and left front descending coronary artery ligation while sham ligation control rats received thoracotomy without ligation. Tumor necrosis factor  TNFα in plasma was detected by ELISA kit; Openfield test and forced swimming test were evaluated 4 weeks after surgical operation. ResultsCompared with the model group，TNFα level of PTX group was significantly lower. The activity, the score of horizontal movement, total time, vertical movement times and climbing times of PTX group were significantly increased and the immobility time was significantly reduced (P <0.05). Conclusion PTX could block the inflammatory induced by myocardial infarction. After myocardial infarction, the rats decreased activity, lost interests in new environment and behavioral despair, all of which indicated the symptoms of depression and indicated that there was a connection between heart and consciousness in pathology. To some extent, the depressive symptoms after acute myocardial infarction relieved after using the PTX, which indicated that the depression after acute myocardial infarction was associated with inflammation.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金面上项目（81072713） 作者单位：100029 北京中医药大学基础医学院\[张文洁（硕士研究生），徐雅\] 作者简介:张文洁（1988- ），女，2012级在读硕士研究生。研究方向：心脑神志相关理论的实验研究。Email:joezuoyou@163.com 通讯作者：徐雅（1972- ），女，博士，副教授。研究方向：中医藏象理论心脑脏腑相关理论与实验研究。Email：xuya@bucm.edu.cn
更新日期/Last Update: 1900-01-01